Severe Morbidity Due to Opisthorchis viverrini and Schistosoma mekongi Infection in Lao People's Democratic Republic

Sayasone, Somphou; Rasphone, Oroth; Vanmany, Monely; Vounatsou, Penelope; Utzinger, Jürg; Tanner, Marcel; Hatz, Christoph; Odermatt, Peter

doi:10.1093/cid/cis528

Cited by 26 publications

(25 citation statements)

References 11 publications

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“…communication, Dr. Bouasy Hongvanthong). These findings warrant further investigations to confirm CCA and to assess its frequency in the different provinces of the country, particularly in Southern Laos, where infection with O. viverrini have been documented (Chai et al, 2005;Chai et al, 2007;Chai et al, 2013;Sayasone et al, 2012).…”

Section: In Our Study the Infection Status Of The Patients Was Assessmentioning

confidence: 79%

“…This is the first study reporting on suspected CCA lesions in communities in Laos. (Mairiang et al, 2006;Mairiang et al, 2012;Sayasone et al, 2012) ranging from non-specific or asymptomatic cases, such as upper right quadrant pain or abdominal irritations to severe manifestations, namely cholangitis, obstructive jaundice, cholelithiasis, gall stones and liver periductal fibrosis, and the most severe outcome of a chronic infection, a fatal CCA. The clinical manifestations in our study were similar to previously reported manifestations.…”

Section: Discussionmentioning

confidence: 99%

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Subtle to severe hepatobiliary morbidity in Opisthorchis viverrini endemic settings in southern Laos

et al. 2015

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Evidence of severe hepatobiliary morbidity associated with Opisthorchis viverrini liver fluke infection including cholangiocarcinoma (CCA) is scarce in Laos although O. viverrini infection is highly prevalent. We assessed hepatobiliary morbidity using abdominal ultrasonography (US) in O. viverrini adult patients in Saravan province, Southern Laos. A random sample of 431 O. viverrini patients from 10 villages underwent abdominal US. Mild, moderate and markedly advanced periductal fibrosis was diagnosed in 7.0%, 66.5%, and 17.0% of patients, respectively. Normal liver parenchyma was seen in only 9.5% of patients. Presence of gall stones (13.2%), sludge (1.4%), gall wall thickening (1.2%), bile duct dilatation (1.6%), fatty liver (12.0%), kidney stones (8.6%) and cysts (7.9%) were diagnosed in considerable frequencies. In five patients (1.2%) hepatobiliary lesions suggesting CCA were diagnosed. Tumour markers, i.e. Interleukin-6, plasminogen activator inhibitor and carbohydrate antigen 19-9 were within normal range. The number of CCA suspected liver masses and hepatobiliary morbidity diagnosed among clinically asymptomatic adult patients in O. viverrini endemic areas presents a major public health concern in Laos. However, definitive diagnosis Opisthorchis-related severe sequelae including CCA is urgently needed to gauge the burden of this deadly disease in Laos.

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Section: In Our Study the Infection Status Of The Patients Was Assessmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Subtle to severe hepatobiliary morbidity in Opisthorchis viverrini endemic settings in southern Laos

et al. 2015

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“…Recent studies have shown that in certain villages S. mekongi infection may reach 50% or more (Sayasone et al, 2011(Sayasone et al, , 2012. Opisthorchis viverrini and minute intestinal flukes (MIF) such as Haplorchis taichui are most frequent .…”

Section: Study Design and Areamentioning

confidence: 99%

“…150,000 people are estimated at risk of infection (Urbani et al, 2002). Foci of intense transmission are communities of the Mekong island areas of Southern Laos (Sayasone et al, 2011(Sayasone et al, , 2012.…”

Section: Introductionmentioning

confidence: 99%

Schistosoma mansoni antigen detects Schistosoma mekongi infection

et al. 2015

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“…Of major public health concern is infection with the liver fluke Opisthorchis viverrini, a food-borne trematodiasis transmitted through the consumption of raw or insufficiently cooked fish. O. viverrini infection may lead to severe hepatobiliary pathologies, depending on the duration and intensity of infection (Mairiang and Mairiang, 2003;Mairiang et al, 2012;Sayasone et al, 2012). A most severe complication is cholangiocarcinoma, a fatal bile duct cancer (Sripa et al, 2011;.…”

Section: Introductionmentioning

confidence: 99%

Raw fish consumption in liver fluke endemic areas in rural southern Laos

et al. 2013

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Consumption of raw or insufficiently cooked fish is a major public health concern in Southeast Asia, and in Lao People's Democratic Republic (Lao PDR), in particular. We aimed to assess the knowledge, attitudes, perceptions and practices of villagers in liver fluke endemic areas related to raw fish preparation, consumption and its health consequences. In February 2010, eight focus group discussions (FGDs, 35 men and 37 women total) and direct observations were conducted in four randomly selected villages in Saravane District, Saravane Province (Lao PDR). FGDs distilled the knowledge, attitudes, perceptions and practices of adult community members on raw fish preparation, consumption and its consequences for health. Conversations were transcribed from notes and tape-recorders. MaxQDA software was used for content analysis. Knowledge regarding the health effects of raw fish consumption was heterogeneous. Some participants did not associate liver fluke infection with any ill health, while others linked it to digestive problems. Participants also associated vegetables and tree leave consumption with liver fluke infection. The majority of FGD participants considered fish flesh that had been prepared with weaver ant extract to be safe for consumption. Visual appearance, taste, smell and personal preference were given as reasons for consuming raw fish dishes. Moreover, participants considered it a traditional way of food preparation, practiced for generations in Laos. Ten different fish dishes that use raw or fermented fish were identified. All FGD participants reported consuming dishes with raw fish. This study reveals a low degree of knowledge among local people on the health risks related to frequent consumption of raw or insufficiently cooked fish. Fish dishes were considered to be 'well-prepared' (that is, 'cooked') even though the fish had not been heated. In future, successful health education campaigns 3 will have to address the specific knowledge, attitudes, perceptions and practices of the concerned population.

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Severe Morbidity Due to Opisthorchis viverrini and Schistosoma mekongi Infection in Lao People's Democratic Republic

Cited by 26 publications

References 11 publications

Subtle to severe hepatobiliary morbidity in Opisthorchis viverrini endemic settings in southern Laos

Subtle to severe hepatobiliary morbidity in Opisthorchis viverrini endemic settings in southern Laos

Schistosoma mansoni antigen detects Schistosoma mekongi infection

Raw fish consumption in liver fluke endemic areas in rural southern Laos

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