Severe laryngeal sarcoidosis in a child managed by intralesional steroid, debulking, and methotrexate

Aa, Jesper Stensig; Toftedal, Peter; Schultz, Joyce Dominique Horsmans; Fast, Søren

doi:10.1080/23772484.2022.2153052

Cited by 1 publication

(1 citation statement)

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“…In children, studies on the natural history of sarcoidosis are rare. In the Danish cohort with a median follow-up of 15 years, 78% of patients recovered completely, 11% still had active disease, 4% had remission with organ involvement, and 7% died [ 4 , 71 , 85 ]. Being a complex systemic disease, sarcoidosis can present itself with a wide range of signs and symptoms, being often considered one of the important “imitators” in pathology.…”

Section: Discussionmentioning

confidence: 99%

The Overlap of Kidney Failure in Extrapulmonary Sarcoidosis in Children—Case Report and Review of Literature

Mocanu

Bogos

Trandafir

et al. 2023

IJMS

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Sarcoidosis is a non-necrotizing granulomatous inflammatory multisystemic disorder of unknown etiology. In children, as in adults, it can involve a few or all organ systems to a varying extent and degree, entailing multisystemic manifestations. Kidney involvement in pediatric-onset adult-type sarcoidosis is rare, with a wide range of renal manifestations, most of them related to calcium metabolism. Children with renal sarcoidosis tend to be more symptomatic than adults, although male patients have a higher prevalence. We present the case of a 10-year-old boy who presented with advanced renal failure with nephrocalcinosis and important hepatosplenomegaly. The diagnosis was established by histopathological examination, with consequent cortisone therapy and hemodialysis. This review emphasizes that sarcoidosis should be considered in the differential diagnosis of pediatric patients with acute kidney insufficiency or chronic kidney disease of an unknown etiology. As far as we know, this is the first study regarding extrapulmonary sarcoidosis in children from Romania.

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Section: Discussionmentioning

confidence: 99%