Severe infections caused by Panton–Valentine leukocidin‐positive Staphylococcus aureus in infants: report of three cases and review of literature

Abstract

Our findings suggest that a prompt identification of Panton-Valentine leukocidin positive Staphylococcus aureus and an appropriate therapy can reduce mortality and long-term sequelae. Further research is needed to specify features of Panton-Valentine leukocidin positive Staphylococcus aureus infections in infants.

Contamination of public transports by Staphylococcus aureus and its carriage by biomedical students: point-prevalence, related risk factors and molecular characterization of methicillin-resistant strains

“…1,2 In the community, the most frequent S. aureus infections are caused by methicillin-sensitive strains, but the recent decades have seen an emerging incidence of methicillin-resistant S. aureus-(MRSA)-related infections and deaths. 3 Initially, most MRSA strains found in the community were only resistant to b-lactam antibiotics, explained by the presence of smaller types of staphylococcal cassette chromosome mec (SCCmec IV and V).…”

“…6e8 Moreover, some S. aureus strains possess the Panton-Valentine leukocidin (PVL), an exotoxin that causes tissue necrosis and leukocytolisis by forming pores in the leukocyte membrane. 2 According to the annual epidemiological report of the European Centre for Disease Prevention and Control (ECDC), the proportion of invasive MRSA in Portugal has been among the highest in Europe (53.8% in 2012). 9 Once the transmission of S. aureus occurs, primarily by direct human-to-human skin contact, such high nosocomial prevalence would be expected to be reflected by an emergence of pathogens in the community, including ubiquitous environmental surfaces.…”

Infections sévères à Staphylococcus aureus sécréteurs de la leucocidine de Panton–Valentine chez l’enfant : un large spectre de presentations cliniques

“…Elles touchent le plus souvent un sujet jeune, sans comorbidité et se présentent par un état septique sévère d'aggravation rapide [5,7,8]. À ce tableau peuvent s'associer des atteintes cutanéo-muqueuses à type d'abcès ou de fasciite nécrosante, des atteintes respiratoires à type de pneumopathie nécrosante avec hémoptysies et détresse respiratoire aiguë ou encore des lésions osseuses multifocales (ostéomyélites) accompagnées d'atteintes des parties molles avoisinantes (myosite, abcès musculaire ou sous-périosté) [1,2,[9][10][11]. Au travers de trois cas, nous illustrons la gravité et la grande variabilité du tableau clinique de l'infection à SA-PVL et proposons une revue de la littérature sur la prise en charge de ce type d'infection.…”

Treating paediatric community‐acquired pneumonia in the era of antimicrobial resistance

“…Community‐acquired MRSA CAP has a rapidly progressive course and a 56–63% mortality rate . Therefore, as we recently reported , MRSA and PVL‐SA infections should be suspected in all children with severe acquired pneumonia, characterised by leukopenia, necrotising or cavitary infiltrates, haemoptysis or empyema, previous history or family history of recurrent furuncles or skin abscesses , independent of culture results and finally by intensive care unit admission .…”