Treating paediatric community‐acquired pneumonia in the era of antimicrobial resistance

Galli, Luisa; Montagnani, Carlotta; Chiappini, Elena; Martino, Maurizio de

doi:10.1111/apa.12503

Cited by 4 publications

(4 citation statements)

References 80 publications

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“…In the post-PIDS/IDSA guidelines era, first-line use of aminopenicillins has increased significantly, but early studies indicate that physicians continue to treat up to 90 % of hospitalized children with broad spectrum cephalosporins [66]. There is good evidence that treatment with appropriately dosed aminopenicillin therapy overcomes most B-lactam resistance, without impairing readmission rates, length of stay (LOS), or costs of hospitalization [48,67,68].…”

Section: Treatment Of Cap Empiric Antibiotic Therapymentioning

confidence: 99%

Management of Community-Acquired Pneumonia in Hospitalized Children

Simon

Parikh

Williams

et al. 2015

Curr Treat Options Peds

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Section: Treatment Of Cap Empiric Antibiotic Therapymentioning

confidence: 99%

Management of Community-Acquired Pneumonia in Hospitalized Children

Simon

Parikh

Williams

et al. 2015

Curr Treat Options Peds

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“…In this issue, Galli et al. review information on drug resistance of Mycoplasma pneumoniae , Staphylococcus aureus and Streptococcus pneumonia , on mechanisms and alternative treatment options. Drug resistance of bacteria causing CAP is becoming a serious problem in paediatrics.…”

Section: Preludementioning

confidence: 99%

“…It may be that the role of PCV7 is partial and that other mechanisms concur, including the appearance of new serotypes, diffusion of minority serotypes and replacement of common serotypes due to natural secular trend. The serotypic switch involves large loci responsible for capsular polysaccharide synthesis, particularly the region near the gene tetM . It is important to note the emergence of pneumococcal serotypes 1, 3 and 19A, which have a higher propensity to cause empyema and include multidrug‐resistant clones .…”

Section: Preludementioning

confidence: 99%

Pneumonia in children: more shadows than lights

Martino

Chiappini

2013

Acta Paediatrica

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“…4 Resistance to antibiotics is one of the causes of high mortality rate. 7 In Asia, 30.1% of Streptococcus pneumoniae is resistant to penicillin. Effectiveness of ampicillin against Haemophillusinfluenzae is 68.7%, therefore the value reflected decreasing ability of ampicillin against Haemophillusinfluenzae.…”

Section: Introductionmentioning

confidence: 99%

Treatment Failure of Ampicillin to Children with Pneumonia at Dr. Hasan Sadikin General Hospital Bandung from 2014–2015

Suharno¹,

Husen²,

Sudarwati³

2017

amj

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Background: Pneumonia is one of the causes of death in infants in developing countries especially Indonesia. Appropriate treatment is needed to decrease mortality rate in children due to pneumonia. Ampicillin is one of first choices empirical antibiotic to children with severe pneumonia. The study was aimed to determine the failure rate of ampicillin in children with severe pneumonia. Methods: This study was a descriptive study which used medical records as source of data. Subjects were children aged 2-59 months with World Health Organization (WHO) defined with severe pneumonia and treated with intravenous ampicillin during January 2014 to July 2015 at Dr. Hasan Sadikin General Hospital Bandung. Samples were obtained using total sampling method while variables were analyzed using statistics software. Results: This study acquired 107 patients who met the inclusion criteria with 23.36% of them aged 2-11 months and 62.21% aged 12-23 months. Majority of subjects were male amounted as 63.55% while female occupied 36.45%. Treatment failure on the third day was 45.8% while 16.7% on the sixth day of therapy with majority failure due to existence of lower chest indrawing. Conclusions: Treatment failure on the third and sixth day of therapy still high that is characterized by the existence of lower chest indrawing as its main factor. [AMJ.2017;4(1):100-6]

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Treating paediatric community‐acquired pneumonia in the era of antimicrobial resistance

Abstract: Knowledge of local epidemiology and an appropriate use of antimicrobial drugs are necessary to treat CAP in this era of antimicrobial resistance.

Cited by 4 publications

References 80 publications

Management of Community-Acquired Pneumonia in Hospitalized Children

Management of Community-Acquired Pneumonia in Hospitalized Children

Pneumonia in children: more shadows than lights

Treatment Failure of Ampicillin to Children with Pneumonia at Dr. Hasan Sadikin General Hospital Bandung from 2014–2015

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