Severe hypertransaminasemia during mild SARS‐CoV‐2 infection: A pediatric case report and literature review

Palpacelli, Alessandra; Martelli, Gabriele; Lattanzi, Bianca; Volpini, Alessandro; Cazzato, Salvatore

doi:10.1002/ped4.12300

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…After discharge, 2 patients recovered a month later, while the rest recovered 2 and 8 months later, respectively ( 25 ). In addition, there was a 30-day-old and a 5-year-old patient with SAH but no liver failure and no need for intensive care ( 26 , 27 ), which is consistent with our participant. Therefore, the prognosis of SAH is not always optimistic.…”

Section: Discussionsupporting

confidence: 89%

Case report: Severe acute hepatitis in a 22-month-old Chinese boy with Omicron sub-variant BA.2.38

Chen

Hong

et al. 2022

Front. Public Health

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The etiology of severe acute hepatitis (SAH) in children is various. We describe the first Chinese case of severe acute hepatitis in a 22-month-old boy with the mild illness of Omicron sub-variant BA.2.38. With the application of Compound Glycyrrhizin Injection (CGI), the patient gradually recovered from acute liver injury (ALI). This case highlights the possibility of severe ALI in children with the non-critical illness of SARS-CoV-2. The management of SAH associated with the pandemic presents challenges for clinicians, and follow-up is in need. The method of differential diagnosis using limited laboratory results is of great value to the clinicians.

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Section: Discussionsupporting

confidence: 89%

Case report: Severe acute hepatitis in a 22-month-old Chinese boy with Omicron sub-variant BA.2.38

Chen

Hong

et al. 2022

Front. Public Health

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“…Thus, liver enzymes may be used as additional markers for the severity of COVID-19 ( 24 – 26 ). It is uncertain whether this is applicable in the pediatric population, but elevated transaminases may be associated with the severity of the disease ( 27 – 29 ).…”

Section: Introductionmentioning

confidence: 99%

Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study

Pavelescu,

Dinulescu,

Păsărică

et al. 2024

Front. Pediatr.

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BackgroundComplete blood count, C-reactive protein and transaminases are routine laboratory parameters investigated in children with infections, including COVID 19. We aimed to evaluate the diagnostic accuracy of these parameters in children diagnosed with COVID 19.MethodsAt the time of admission, children with COVID 19 suggestive symptoms were tested RT-PCR for SARS CoV-2 and were allocated to either the study group (RT-PCR SARS CoV-2 positive) or control group (RT-PCR SARS CoV-2 negative). All children were evaluated by complete blood count, CRP, and transaminases.ResultsWhen comparing the two groups, we identified significantly lower values for leukocytes (p < 0.001), neutrophils (p < 0.001), lymphocytes (p < 0.001) and thrombocytes (p = 0.014), but no significantly different values for CRP (p = 0.916) and monocytes (p = 0.082). A diagnostic score for COVID-19 was compiled using the abovementioned parameters—presence of fever, number of lymphocytes and aspartate-aminotransferase. Performance was tested, showing a positive discrimination value (AUC of 0.703)—81.5% sensitivity, 50.6% specificity.ConclusionsThe leukocytes, neutrophils and lymphocytes have significantly lower values in COVID-19 children. The proposed score based on the presence of fever the values of lymphocytes and AST has a good sensitivity in predicting COVID-19 infection.

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A Case of Severe Hepatitis in Infant Twins With COVID-19

Heston¹,

Sharma²,

Johnson³

et al. 2023

Cureus

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We report a case of nine-month-old twins who presented with bright green diarrhea along with progressively worsening jaundice over one week. On initial evaluation, they were found to have significantly elevated liver enzymes, bilirubin, and alkaline phosphatase levels but without signs of liver failure. They were tested for multiple causes of liver injury including autoimmune and infectious etiologies, which were negative as well. Both twins were incidentally found to be positive for COVID-19 on testing per hospital protocol but did not have any respiratory symptoms. They were monitored closely during their hospital stay and showed clinical stability but with only slight improvement in abnormal lab levels. Ultimately, they were discharged with close outpatient follow-up. They demonstrated full resolution of all lab abnormalities and symptoms two months post discharge.

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Severe hypertransaminasemia during mild SARS‐CoV‐2 infection: A pediatric case report and literature review

Cited by 3 publications

References 11 publications

Case report: Severe acute hepatitis in a 22-month-old Chinese boy with Omicron sub-variant BA.2.38

Case report: Severe acute hepatitis in a 22-month-old Chinese boy with Omicron sub-variant BA.2.38

Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study

A Case of Severe Hepatitis in Infant Twins With COVID-19

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