2021
DOI: 10.1002/ped4.12300
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Severe hypertransaminasemia during mild SARS‐CoV‐2 infection: A pediatric case report and literature review

Abstract: Introduction Liver injury during SARS‐CoV‐2 infection has a multifactorial pathogenesis and it is frequent in pediatric cases. Case presentation We report a case with severe hypertransaminasemia associated with mild SARS‐CoV‐2 infection. Conclusion This highlights the potential need of hepatic function evaluation during acute illness and follow‐up even in non‐critically ill children with COVID‐19.

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Cited by 3 publications
(3 citation statements)
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“…After discharge, 2 patients recovered a month later, while the rest recovered 2 and 8 months later, respectively ( 25 ). In addition, there was a 30-day-old and a 5-year-old patient with SAH but no liver failure and no need for intensive care ( 26 , 27 ), which is consistent with our participant. Therefore, the prognosis of SAH is not always optimistic.…”
Section: Discussionsupporting
confidence: 89%
“…After discharge, 2 patients recovered a month later, while the rest recovered 2 and 8 months later, respectively ( 25 ). In addition, there was a 30-day-old and a 5-year-old patient with SAH but no liver failure and no need for intensive care ( 26 , 27 ), which is consistent with our participant. Therefore, the prognosis of SAH is not always optimistic.…”
Section: Discussionsupporting
confidence: 89%
“…A more recent pediatric case report showed a similar presentation in a 30-day-old female infant with a severe elevation of both AST and ALT without liver failure [ 6 ]. The patient had a course almost identical to our patients and recovered with conservative measures.…”
Section: Discussionmentioning
confidence: 96%
“…Thus, liver enzymes may be used as additional markers for the severity of COVID-19 ( 24 26 ). It is uncertain whether this is applicable in the pediatric population, but elevated transaminases may be associated with the severity of the disease ( 27 29 ).…”
Section: Introductionmentioning
confidence: 99%