Severe Fever with Thrombocytopenia Syndrome Virus, Shandong Province, China

Zhao, Li; Zhai, Shenyong; Wen, Hongling; Cui, Feng; Chi, Yuanyuan; Xue, Fuzhong; Wang, Qian; Wang, Zhiyu; Zhang, Shoufeng; Song, Yue; Du, Jun; Yu, Xue Jie

doi:10.3201/eid1806.111345

Cited by 132 publications

(107 citation statements)

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“…Previous studies demonstrated that adult mice of the KM, BALB/c, and C57/BL6 strains are not susceptible to SFTSV regardless of the inoculation route (9,10). The only signs of SFTSV infection in C57/BL6 mice are slightly low white blood cell and platelet counts at one time point (7). These studies indicated that immunocompetent adult mice are not susceptible to SFTSV.…”

Section: Discussionmentioning

confidence: 70%

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The Pathogenesis of Severe Fever with Thrombocytopenia Syndrome Virus Infection in Alpha/Beta Interferon Knockout Mice: Insights into the Pathologic Mechanisms of a New Viral Hemorrhagic Fever

Liu

Paessler

et al. 2014

J Virol

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114

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Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly discovered Phlebovirus causing an emerging hemorrhagic fever in East Asia, with reported case fatality rates up to 30%. Despite the high case fatality rate and large number of persons at risk of infection, the pathobiology of the disease is unknown, and no effective animal model has been available for investigating its pathogenesis. We have studied mice and hamsters as potential small-animal models of SFTSV infection following subcutaneous, intraperitoneal, or intracerebral inoculation. Animal tissues were processed for viral load determination, histopathology, immunohistochemistry, and confocal microscopic studies. We found that immunocompetent adult mice and hamsters did not become ill after SFTSV infection. However, alpha/beta interferon receptor knockout (IFNAR ؊/؊ ) mice were highly susceptible to SFTSV infection, and all mice died within 3 to 4 days after subcutaneous inoculation of 10 6 focus-forming units of SFTSV. Histologic examination of tissues of IFNAR ؊/؊ mice infected with SFTSV showed no detectable lesions. In contrast, by immunohistochemistry virus antigen was found in liver, intestine, kidney, spleen, lymphoid tissue, and brain, but not in the lungs. Mesenteric lymph nodes and spleen were the most heavily infected tissues. Quantitative reverse transcription-PCR (RT-PCR) confirmed the presence of virus in these tissues. Confocal microscopy showed that SFTSV colocalized with reticular cells but did not colocalize with dendritic cells, monocytes/macrophages, neutrophils, or endothelium. Our results indicate that SFTSV multiplied in all organs except for lungs and that mesenteric lymph nodes and spleen were the most heavily infected tissues. The major target cells of SFTSV appear to be reticular cells in lymphoid tissues of intestine and spleen.

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Section: Discussionmentioning

confidence: 70%

“…SFTSV is believed to be transmitted by ticks, because the virus has been detected in Haemaphysalis longicornis ticks collected from domestic animals (1). Domestic animals such as goats, dogs, and cattle within the area of endemicity have a high seroprevalence of SFTSV antibodies (7,8). However, the animal host(s) of SFTSV remains elusive.…”

mentioning

confidence: 99%

The Pathogenesis of Severe Fever with Thrombocytopenia Syndrome Virus Infection in Alpha/Beta Interferon Knockout Mice: Insights into the Pathologic Mechanisms of a New Viral Hemorrhagic Fever

Liu

Paessler

et al. 2014

J Virol

Self Cite

114

126

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“…In Shandong Province, 83%-95% of goats were positive for SFTSV antibodies [15][16][17]; in Jiangsu Province, 57% of goats, 32% of cattle, 6% of dogs, 5% of pigs, and 1% of chickens were seropositive for SFTSV [17]; and in Hubei Province, 55.0% (6/11) of dogs, 36.7% (2/3) of goats, and 80.0% (4/5) of cattle were seropositive for SFTSV [18]. However, only a small proportion of the animals studied (1.7%-5.3%) were found to carry low levels of viral RNA in their sera [19].…”

Section: Transmission Route Vectors and Animal Hosts Of Sftsvmentioning

confidence: 99%

“…Serosurveillance indicated that 1.0%-3.8% of the population in the hilly areas of China were positive for SFTSV antibodies [15][16][17], suggesting that although a large population was infected with SFTSV, a very small proportion of …”

Section: Susceptible Populationmentioning

confidence: 99%

An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV

Zhang

Liu

Zhao

et al. 2013

Sci. China Life Sci.

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in rural areas of China and is caused by a new bunyavirus, SFTSV, named after the disease. The transmission vectors and animal hosts of SFTSV are unclear. Ticks are the most likely transmission vectors and domestic animals, including goats, dogs, and cattle, are potential amplifying hosts of SFTSV. The clinical symptoms of SFTS are nonspecific, but major symptoms include fever, gastrointestinal symptoms, myalgia, dizziness, joint pain, chills, and regional lymphadenopathy. The most common abnormalities in laboratory test results are thrombocytopenia (95%), leukocytopenia (86%), and elevated levels of serum alanine aminotransferase, aspartate aminotransferase, creatine kinase, and lactate dehydrogenase. The fatality rate for SFTS is 12% on average, and the annual incidence of the disease is approximately five per 100000 of the rural population.

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“…SFTSV was thought to be mainly transmitted by ticks, based on evidence from tick exposure history, SFTSV detection, and sequence analysis (1,2). SFTS was first reported in 2009 in China (3); by 2013, more than 1,700 laboratory-confirmed cases had been reported in 14 provinces, with a fatality rate of 7-15% (4).…”

Section: Introductionmentioning

confidence: 99%