Presence of Antibodies against Severe Fever with Thrombocytopenia Syndrome Virus in Non-Endemic Areas of China

Huang, Xiaoxia; Zhang, Zhongxin; Jin, Guang‐Hui; Wang, Xiaofang; Tan, Chusheng; Yin, Hongfeng; Wang, Shiwen

doi:10.7883/yoken.jjid.2016.214

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…6 studies were of high quality, other studies were of moderate quality ( Table 1 ). Generally, the most prevalence studies were conducted in the center and east of China (Shaanxi [ 22 ], Henan [ 23 ], Hubei [ 24 , 25 ], Zhejiang [ 26 – 28 ], Jiangsu [ 29 – 32 ], Jiangsu&Anhui [ 33 ], Anhui [ 34 – 36 ], and Shandong provinces [ 37 – 42 ]), the location of referred provinces in China was shown in Fig 2 .…”

Section: Resultsmentioning

confidence: 99%

“…However, the results of seroprevalence in healthy people among different age groups were controversial. Some studies reported an increasing trend with age about the seroprevalence of SFTSV in healthy population [ 22 , 23 , 28 , 31 , 34 ], while other studies failed to find any significant difference among different age groups [ 30 , 33 , 41 – 43 ]. In this meta-analysis, the pooled data indicated the seroprevalence of SFTSV in people over 40 years old was close to people who less than 40 years old.…”

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of severe fever with thrombocytopenia syndrome virus in China: A systematic review and meta-analysis

Li¹,

Tong²,

Li³

et al. 2017

PLoS ONE

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ObjectiveSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus-SFTSV. The seroprevalence of anti-SFTSV antibodies including immunoglobulin G (IgG) and immunoglobulin M (IgM), specific to SFTSV in the general population has been investigated in various epidemiological studies with inconsistent results. Here, we clarify this discrepancy and reach a more comprehensive result by mean of a meta-analysis.MethodsAll relevant articles were searched in the electronic databases (PubMed, Web of science, Embase, Chinese National Knowledge Infrastructure database, Chinese Wanfang database) up to November 2016. The pooled seroprevalence and 95% confidence intervals (95% CIs) were calculated by random- or fixed- model on the basis of heterogeneity.ResultsIn total, 21 studies containing 23,848 blood samples from 7 provinces were included in this meta-analysis. The minimum and maximum reported seroprevalences of SFTSV among humans in China were 0.23% and 9.17%, respectively. The overall pooled seroprevalence of SFTSV antibodies was 4.3% (95%CI: 3.2%-5.5%). The pooled prevalence was 5.9% (95%CI: 4.7%-7.0%) in Zhejiang province, 4.9% (95%CI: 4.1–5.8%) in Anhui province, 3.9% (95%CI: 1.3%-6.4%) in Shandong province, and 0.7% (95%CI: 0.2%-1.1%) in Jiangsu province. Stratified by occupation, the pooled prevalence of farmer was 6.1% (95%CI: 3.4%-8.9%) and others (mainly are students) was 3.3% (95%CI: 2.4%-4.2%). Additionally, seroprevalence of SFTSV in people who lived in the same village with the patient were higher than that of people who lived in a different village. Seropositive rates in sampling years after 2012 were higher than that before 2012. The prevalence of SFTSV did not differ by age or gender. Sensitive analysis by omitting one study at a time indicated the results of the pooled seroprevalence were robust.ConclusionsSeroprevalence of SFTSV among healthy population in central and eastern China is high. Surveillance efforts on mild or asymptomatic infections among endemic persons are needed.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Seroprevalence of severe fever with thrombocytopenia syndrome virus in China: A systematic review and meta-analysis

Li¹,

Tong²,

Li³

et al. 2017

PLoS ONE

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“…Because the primary mode of transmission by which SFTSV infects humans is a bite by a SFTSV-infected tick, an occupational risk was noted for individuals working in farms as well as for those in contact with domestic and/or wild animals (12)(13)(14). SFTSV is known to circulate in Japan because patients with SFTS are being notified (6) because the SFTSV genome is detected in several tick species and a high prevalence of anti-SFTSV antibody seropositivity was observed among deer, wild boars, dogs, and raccoon dogs (15).…”

Section: Discussionmentioning

confidence: 99%

Low Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus Antibodies in Individuals Living in an Endemic Area in Japan

et al. 2018

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SUMMARY:Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infection with a high mortality rate. It is caused by the SFTS virus (SFTSV) and is endemic in some areas in western Japan, including the Kagoshima prefecture. In the present study, healthy individuals living in this prefecture were examined to assess for anti-SFTSV seroprevalence. An initial study was performed using the serum samples collected from a total of 646 individuals living in Kagoshima. At the same time, a questionnaire was used to collect information (such as occupation and a history of tick bite). Enzyme-linked immunosorbent assay and indirect immunofluorescence assay were used for the screening. Finally, the seroprevalence of anti-SFTSV antibodies was confirmed using a neutralization assay. Only 2 (0.3%) out of 646 study participants were positive for anti-SFTSV antibodies. No significant difference was observed between individuals who are at a high or low risk of tick bite in terms of seropositivity. Next, a total of 1,000 serum samples collected from general blood donors by the Japanese Red Cross Kyushu Block Blood Center were tested. None of these samples tested positive for anti-SFTSV antibodies. These results suggest a low seroprevalence of anti-SFTSV antibodies in healthy individuals living in an endemic area in Japan.

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“…Sera were tested for SFTSV-specific IgM and IgG antibodies using an ELISA kit (Zhongshan Bio-Tech Co., Ltd.) based on the procedures described previously [11]. In brief, 100 μl of diluted serum, 100 μl of horseradish peroxidase (HRP)-labelled enzyme conjugate, and the chromogenic substrate were added to each well.…”

Section: Methodsmentioning

confidence: 99%

Detection of SFTS virus RNA and antibodies in severe fever with thrombocytopenia syndrome surveillance cases in endemic areas of China

et al. 2019

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Background Severe fever with thrombocytopenia syndrome (SFTS) is a newly identified severe infectious disease caused by SFTS phlebovirus (SFTSV). SFTS monitoring has been carried out since 2010 in mainland China. We analysed the detection results of SFTSV RNA and antibody in SFTS surveillance cases to provide basic data for SFTS diagnosis. Methods This study was conducted in Shandong Province. Sera of SFTS surveillance cases were collected to detect SFTSV RNA and antibody by real-time RT-PCR and enzyme-linked immunosorbent assay, respectively. Detection rates were calculated. SPSS 18.0 (Chicago, IL, USA) was used for statistical analysis to compare the detection rates of SFTSV RNA and antibodies among different sera groups. Results A total of 374 SFTS surveillance cases were enrolled. Overall, 93.3% (349/374) of the sera samples were collected within 2 weeks after onset, and 6.7% (25/374) were collected between 15 days and 45 days. Of these, 183 (48.9%) were positive for SFTSV RNA. The SFTSV RNA-positive rate peaked (52.2%) in samples collected ≤7 days after onset and then showed a decreasing trend. The detection rate of SFTSV-specific IgM antibody was 30.5% (46/151) and was highest in samples collected between 8 and 14 days (43.3%, 26/60). The positive rate of SFTSV-specific IgG antibody (17.9%, 27/151) showed an increasing trend with the specimen collection time. In total, 74.8% (113/151) of sera samples had the same SFTSV RNA and IgM antibody detection results. However, 23.2% (29/125) of SFTSV RNA-negative cases were IgM antibody-positive, and 8.6% (9/105) of IgM antibody-negative cases were SFTSV RNA-positive. Conclusions SFTSV RNA detection was preferred for SFTSV infection during disease surveillance. For highly suspected SFTS cases, IgM antibody is suggested to make a comprehensive judgement.

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Presence of Antibodies against Severe Fever with Thrombocytopenia Syndrome Virus in Non-Endemic Areas of China

Cited by 11 publications

References 19 publications

Seroprevalence of severe fever with thrombocytopenia syndrome virus in China: A systematic review and meta-analysis

Seroprevalence of severe fever with thrombocytopenia syndrome virus in China: A systematic review and meta-analysis

Low Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus Antibodies in Individuals Living in an Endemic Area in Japan

Detection of SFTS virus RNA and antibodies in severe fever with thrombocytopenia syndrome surveillance cases in endemic areas of China

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