Severe Erythema Multiforme

Erythema Multiforme and Nephritis

“…None of the standard textbooks of dermatology or general medicine mention nephritis in this condition. Lever (1944) stated that no renal involvement occurs save transient albuminuria." Ashby and Lazar (1951) reported four cases of erythema multiforme and reviewed the literature to that date but did not mention nephritis.…”

Drug-Induced Oral Erythema Multiforme

“…The major variant of EM is characterized by severe and acute systemic illness and, in almost all cases, uni-or pluriorificial mucosa involve ment [3,6,13,18,21,23,24], As to the etiology of EM, a multitude of causative factors have been incriminated in cluding a variety of bacterial, viral and fun gal infections, gastrointestinal upset, even malignancies, and allergy against drugs or their metabolites [2,13,[16][17][18]23], Surpris ingly, there is a scarcity of reliable data con cerning the prevalence rates of drug-induced EM in the respective literature available so far. This lack of information prompted us to…”

Electrocardiographic Changes in Reiter's Syndrome

“…Gadrat and Morel (1935) found electrocardiographic changes in a man with gonococcal urethritis and arthritis, and Bang (1940) made an electrocardiographic diagnosis of gonococcal myocarditis in six men, five of whom had " recurrent specific arthritis ", and the sixth acute urethritis and arthritis. Lever and Crawford (1944) Trier (1950). Shapiro, Lipkis, Kahn, and Heid (1949) described electrocardiographic changes in four female cases of acute gonococcal polyarthritis, which " demonstrate a pertinent exception to the axiom that polyarthritis plus an abnormal and unstable electrocardiogram is pathognomonic of acute rheumatic fever ".…”