2006
DOI: 10.1001/archderm.142.2.213
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Severe Eczematous Skin Reaction After High-Dose Intravenous Immunoglobulin Infusion

Abstract: Background: High-dose intravenous immunoglobulins (IVIGs) are increasingly used to treat inflammatory and/or autoimmune disorders. In dermatology, they provide therapeutic benefit in Kawasaki disease and certain cases of dermatomyositis. While most adverse effects following IVIG treatment are not severe, occasionally more severe adverse effects occur, including anaphylactic reactions and acute, usually transient, renal failure. Observations:We report 4 cases of a characteristic severe extensive eczematous reac… Show more

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Cited by 69 publications
(50 citation statements)
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“…In fact, Vecchietti et al (2) assessed that neurologic disorders, frequently associated with immunological alterations or viral infections, may predispose the occurrence of pompholyx related to IVIG therapy. The authors noticed that most of the cases of IVIGrelated pompholyx reported in the literature occurred among patients who had received IVIG for neurologic affections (31/37 cases described in this review), although considering the bias of more frequent use of IVIG therapy by neurologists (2). Inaddition, it should be pointed out that IVIGs for neurological diseases are generally administrated at higher doses than those used for immunodeficiency disorders (6).…”
Section: Discussionmentioning
confidence: 99%
“…In fact, Vecchietti et al (2) assessed that neurologic disorders, frequently associated with immunological alterations or viral infections, may predispose the occurrence of pompholyx related to IVIG therapy. The authors noticed that most of the cases of IVIGrelated pompholyx reported in the literature occurred among patients who had received IVIG for neurologic affections (31/37 cases described in this review), although considering the bias of more frequent use of IVIG therapy by neurologists (2). Inaddition, it should be pointed out that IVIGs for neurological diseases are generally administrated at higher doses than those used for immunodeficiency disorders (6).…”
Section: Discussionmentioning
confidence: 99%
“…Yorgunluk, ateş ya da mide bulantısı gibi şikayetler infüzyon sonrasında da gelişebilmekte ve 24 saate kadar devam edebilmektedir. Deri lezyonları ekzematöz döküntüler, ürtiker, likenoid reaksiyonlar, kaşıntı ve peteşi şeklinde bildirilmiştir 44,45 . Daha nadir görülen ama daha şiddetli yan etkiler tromboembolik olaylar, hemolitik anemi, akut akciğer hasarı, aseptik menenjit, anafilaksi ve renal tubuler nekroz şeklindedir 30,46 .…”
Section: Azatiyoprinunclassified
“…Although case-report studies reported that KD patients with atypical skin rash might be associated with CALs and IVIG treatment 7,8) , the correlation between skin rash characteristics and CALs is still unclear.…”
Section: Introductionmentioning
confidence: 99%