Severe damages caused by Malathion exposure in Colossoma macropomum

Souza, Samara Silva de; Machado, Rubia Neris; Costa, Jaqueline Custódio da; Campos, Derek Felipe; Silva, Grazyelle Sebrenski da; Almeida-Val, Vera Maria Fonseca de

doi:10.1016/j.ecoenv.2020.111340

Cited by 9 publications

(2 citation statements)

References 48 publications

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“…Malathion causes less noticeable alterations in fish mitochondrial respiration and OXPHOS than chlorpyrifos. Malathion at 7.30 mg•L −1 for 96 h, for example, had no effect on the mitochondrial function of tambaqui liver, with no alterations in the activity of any protein complexes [127]. In contrast, malathion compromises oxidative phosphorylation in Oncorhynchus kisutch, causing a 38% reduction in electron transport system respiration capacity and a 46% reduction in respiratory control rate, which may compromise mitochondrial ATP generation [172].…”

Section: Mitochondrial and Lysosome Toxicitymentioning

confidence: 98%

Pesticide Pollution: Detrimental Outcomes and Possible Mechanisms of Fish Exposure to Common Organophosphates and Triazines

Khatib

Rychter

Falfushynska

2022

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Pesticides are well known for their high levels of persistence and ubiquity in the environment, and because of their capacity to bioaccumulate and disrupt the food chain, they pose a risk to animals and humans. With a focus on organophosphate and triazine pesticides, the present review aims to describe the current state of knowledge regarding spatial distribution, bioaccumulation, and mode of action of frequently used pesticides. We discuss the processes by which pesticides and their active residues are accumulated and bioconcentrated in fish, as well as the toxic mechanisms involved, including biological redox activity, immunotoxicity, neuroendocrine disorders, and cytotoxicity, which is manifested in oxidative stress, lysosomal and mitochondrial damage, inflammation, and apoptosis/autophagy. We also explore potential research strategies to close the gaps in our understanding of the toxicity and environmental risk assessment of organophosphate and triazine pesticides.

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Section: Mitochondrial and Lysosome Toxicitymentioning

confidence: 98%

Pesticide Pollution: Detrimental Outcomes and Possible Mechanisms of Fish Exposure to Common Organophosphates and Triazines

Khatib

Rychter

Falfushynska

2022

JoX

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“…The lipid peroxidation of cellular membranes is also another negative feature attributed to malathion toxicity (Chorehi et al, 2013;Olakkaran et al, 2020;Ullah et al, 2018). Consequently, an imbalance in the physiological function and immune capacity results from malathion toxicity (Silva de Souza et al, 2020). The toxicity of malathion induced oxidative stress and liver failure in rohu (Labeo rohita, Hamilton) (Ullah et al, 2018), goldfish (Carassius auratus gibelio) (Huculeci et al, 2009), and Channa punctatus (Bloch) (Bharti and Rasool, 2021).…”

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confidence: 99%

Lactobacillus casei (IBRC-M 10,711) ameliorates the growth retardation, oxidative stress, and Immunosuppression induced by malathion toxicity in goldfish (Carassius auratus)

Saleh

Hasan²,

Al‐Shawi

et al. 2022

Annals of Animal Science

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Probiotics can functionality improve fish wellbeing and are suggested as antioxidative agents to protect fish from xenobiotics toxicity. Herein, dietary Lactobacillus casei (IBRC-M 10,711) was included in the diets of goldfish (Carassius auratus) to protect against malathion toxicity. Fish (12.47 ± 0.06 g) were randomly allocated to six groups (triplicates), as follows: T1) control; T2) fish exposed to 50% of malathion 96 h LC50; T3) L. casei at 106 CFU/g diet; T4) L. casei at 107 CFU/g diet; T5) fish exposed to 50% of malathion 96 h LC50 + L. casei at 106 CFU/g diet; T6) fish exposed to 50% of malathion 96 h LC50 + L. casei at 107 CFU/g diet. After 60 days, goldfish fed T4 had the highest final body weight (FBW), weight gain (WG), and specific growth rate (SGR), and the lowest feed conversion ratio (FCR) among the groups (P < 0.05). However, the T2 group showed lower FBW, WG, and SGR and higher FCR than fish in T1 (P < 0.05). Fish in the T4 group had the highest blood total proteins, albumin, and globulin, while fish in T2 had the lowest levels (P < 0.05). Fish in the group T2 had the highest triglycerides, cholesterol, cortisol, lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels in the blood, while fish fed T4 had the lowest values (P < 0.05). The superoxide dismutase (SOD) and catalase (CAT) showed the highest activities in T3 and T4 groups, and the lowest SOD was seen in the T2 group, whereas the lowest CAT was seen in the T2, T5, and T6 groups (P < 0.05). Fish in the T5 and T6 groups had higher glutathione peroxidase (GSH-Px) activities than fish in T1 and T2 groups but T3 and T4 groups showed the highest values (P < 0.05). T2 group had the highest malondialdehyde (MDA) level, while T3 and T4 groups had the lowest MDA level (P < 0.05). Blood immunoglobulin (Ig) and lysozyme activity were significantly higher in T3 and T4 groups and lower in the T2 group than in the control (P < 0.05). The alternative complement pathway (ACH50) was significantly higher in T2, T3, T4, T5, and T6 groups than in the T1 group (P < 0.05). Skin mucus Ig was significantly higher in T3 and T4 groups and lower in the T2 group than in the control (P < 0.05). The highest lysozyme activity, protease, and ACH50 in the skin mucus samples were in the T4 group, while the lowest values were in the T2 group (P < 0.05). In conclusion, dietary L. casei protects goldfish from malathion-induced growth retardation, oxidative stress, and immunosuppression.

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The protective effects of quercetin on the physiological responses in malathion-exposed common carp, Cyprinus carpio

Nasirin

Najm

Chen

et al. 2022

Trop Anim Health Prod

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Severe damages caused by Malathion exposure in Colossoma macropomum

Cited by 9 publications

References 48 publications

Pesticide Pollution: Detrimental Outcomes and Possible Mechanisms of Fish Exposure to Common Organophosphates and Triazines

Pesticide Pollution: Detrimental Outcomes and Possible Mechanisms of Fish Exposure to Common Organophosphates and Triazines

Lactobacillus casei (IBRC-M 10,711) ameliorates the growth retardation, oxidative stress, and Immunosuppression induced by malathion toxicity in goldfish (Carassius auratus)

The protective effects of quercetin on the physiological responses in malathion-exposed common carp, Cyprinus carpio

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