Severe cutaneous necrosis associated with type I cryoglobulinemia

Murphy, Anne; Kilian, Adam; Lowe, Lori; Marder, Wendy

doi:10.1016/j.jdcr.2019.06.020

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…[9][10][11] Renal and neurologic involvement are more frequent findings in patients with mixed cryoglobulinemia, findings not seen in our patient. 8 Based on presenting symptoms, physical exam findings, pathophysiology report from biopsy along with laboratory results, and current literature on cryoglobulinemia, we affirm and believe that this patient has cryoglobulinemia type I secondary to MGUS who was successfully treated with rituximab and a prednisone taper.…”

Section: Discussionsupporting

confidence: 53%

“…Type I cryoglobulinemia only accounts for 10-15% of people with cryoglobulinemia whereas mixed constitutes the rest. 8 Type I is most associated with cutaneous involvement including recurrent episodes of purpuric eruptions, livedo reticularis, acrocyanosis, Raynaud's syndrome, and even severe infarction skin necrosis. [9][10][11] Renal and neurologic involvement are more frequent findings in patients with mixed cryoglobulinemia, findings not seen in our patient.…”

Section: Discussionmentioning

confidence: 99%

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Cryoglobulinemia Type I in Patient with History of Monoclonal Gammopathy of Unknown Significance: A Case Report

Mathis

Marrone²

2023

J of Skin

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Cryoglobulinemia is a form of vasculitis causing inflammation of the blood vessels due to aggregated proteins that clump together at cold temperatures, causing damage to skin, muscles, nerves, and other organs. An elderly black female presented with superficial ulceration with overlying eschar within areas of retiform purpura of her bilateral thighs present for 8 months. She was previously diagnosed with vaso-occlusive disease before presenting to our clinic for further evaluation and management. Upon investigation, we have concluded that the patient has cryoglobulinemia type I.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Cryoglobulinemia Type I in Patient with History of Monoclonal Gammopathy of Unknown Significance: A Case Report

Mathis

Marrone²

2023

J of Skin

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“…The cryoglobulin concentration means were higher in patients than in controls., Table 4. The findings of negative precipitation zones in IgG, IgA and IgM partigens may be attributed to;i-the difference in mucosal cryoglobulin antigenic specificity than mucosal normo-globulin antigenic specificity and /or secretory peace cryoglobulin specificity [17,18] and ii-the concentration limits of these cryoglobulin were below the limits of sensitivity of the tempted partigens [Manufacturer instruction].The recovered oral mucosal cryoglobulin concentrations were within the clinically indicative for a potential role that may be played in the pathogenesis and immunopathogenesis of chronic gingivitis and chronic periodontitis, as it may precipitate in the local blood vessels of gum and periodontium causing local vasculitis [20,21,17,19,22]. Three immune herd plots were noted as low, moderate and high responders, Table 5.…”

Section: Fig 2 Oral Mucosal Cryoglobulin Herd Plot Of Chronic Periodo...mentioning

confidence: 99%

Oral mucosal Cryoglobulin [ICD-10-CM Diagnostic Code D89.9 Cryoglobulin], Oral Mucosal Herd Immunity and the Immune Herd Plots among Periodontal Disease Patients

Shnawa

AL-Amedie

AL-Fatlawi

2022

JPRI

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Forty five patients were diagnosed by specialist dentist of the team as periodontal disease patients. Basically they were found to be chronic periodontitis and chronic gingivitis. The study male and female patient groups [25 males and 20 females] were subjected to the detection of oral mucosal cryoglobulin and tempts to use cryoglobulin as a marker for oral mucosal herd immunity among these patients. Oral mucosal cyoprotein solutions were separated and characterized as oral mucosal cryoglobulin [ICD-10-CM Diagnostic code, D89.9 Cryglobulin]. Mucosal cryocrit percentages were ranged from one to seven percent. Oral mucosal cryoglobulin concentrations were ranged between 0.13 up to 2 mg/dl. In chronic periodontitis patients and 0.15 up to1.96 mg/dl.in chronic gingivitis patients. The individuals Mucosal herd immunity constitutes three basic immune fractions; low, moderate and high cryoglobulin responders. The immune herd plot types were matched as Gaussian distribution plot types. The findings of oral mucosal cryoglobulin among these patients in clinically indicative concentrations for the potential role may be played in the pathogenesis of chronic gingivitis and chronic periodontitis as it may cause precipitates in the local blood vessels of gum and periodotium.

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Severe cutaneous necrosis associated with type I cryoglobulinemia

Cited by 2 publications

References 8 publications

Cryoglobulinemia Type I in Patient with History of Monoclonal Gammopathy of Unknown Significance: A Case Report

Cryoglobulinemia Type I in Patient with History of Monoclonal Gammopathy of Unknown Significance: A Case Report

Oral mucosal Cryoglobulin [ICD-10-CM Diagnostic Code D89.9 Cryoglobulin], Oral Mucosal Herd Immunity and the Immune Herd Plots among Periodontal Disease Patients

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