Cryoglobulinemia Type I in Patient with History of Monoclonal Gammopathy of Unknown Significance: A Case Report

Abstract

Cryoglobulinemia is a form of vasculitis causing inflammation of the blood vessels due to aggregated proteins that clump together at cold temperatures, causing damage to skin, muscles, nerves, and other organs. An elderly black female presented with superficial ulceration with overlying eschar within areas of retiform purpura of her bilateral thighs present for 8 months. She was previously diagnosed with vaso-occlusive disease before presenting to our clinic for further evaluation and management. Upon investigation, we have concluded that the patient has cryoglobulinemia type I.