Severe community‐acquired Acinetobacter baumannii pneumonia: An emerging highly lethal infectious disease in the Asia–Pacific

Abstract

1-7 days). The median Acute Physiology and Chronic Health Evaluation II score was 28.5 (range 6-36). Six patients presented with septic shock, lactic acidosis, acute kidney injury and respiratory failure, necessitating ICU care; five of thesepatients eventually died. All patients received empirical antibiotics, including third-generation cephalosporins,

Phenotypic and Molecular Characterization of Acinetobacter Clinical Isolates Obtained from Inmates of California Correctional Facilities

“…in a prison, there have been increased reports of nursing home-associated or community-acquired Acinetobacter infections (16,34,46,47,58). For instance, Sengstock and coworkers identified MDR A. baumannii as an emerging pathogen among older adults in nursing homes (58), institutions that are distinct from hospitals.…”

“…More alarmingly, during the 6-year period Acinetobacter prevalence increased 25%, and their resistance to imipenem and ampicillin-sulbactam increased from 1.8 to 13.6% (58). Additionally, Ong et al found that eight patients in Singapore were diagnosed with community-acquired pneumonia due to infections by A. baumannii (46).…”

“…In particular, multidrug-resistant (MDR) clinical isolates of this bacterium have been reported as infectious agents in many soldiers wounded in Afghanistan and Iraq (2,24,27,78). In addition, A. baumannii is recognized as an increasingly important cause of community-acquired pneumonia and other infections (8,16,46,47). Besides A. baumannii, other Acinetobacter spp., including genomic species 3 (gen. sp.…”

Are we closing in on an "elusive enemy"? The current status of our battle withAcinetobacter baumannii

“…Almost exclusive to tropical and subtropical regions of Asia-Pacific, this syndrome presents in the warmer months of the year. 45 Curiously, A. baumannii is a highly prevalent pathogen and colonizer in tropical, warm climates, whereas in temperate climates the reservoir of epidemic strains is located in hospitals and long-term care facilities. 6,[46][47][48] Researchers in the United States have documented a 17% increase in the monthly rate of A. baumannii infection for each 10 degrees F increase in temperature.…”

Genome Sequences of Four Divergent Multidrug-Resistant Acinetobacter baumannii Strains Isolated from Patients with Sepsis or Osteomyelitis

“…cinetobacter baumannii is a nonfermentative, Gram-negative coccobacillus that is the etiological agent of nosocomial infections resulting in septicemia, meningitis, endocarditis, pneumonia, and wound and urinary tract infections (7,8,10). The rapid development of antimicrobial resistance and nosocomial spread of this emerging pathogen have elicited great interest (5,7,8).…”