Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors

Habib, Nancy; Salaro, Cristina; Al‐Ghaithi, Khalid; Phelps, Robert; Saggar, Sarika; Cohen, Steven R.

doi:10.1111/j.1365-4632.2009.04319.x

Cited by 11 publications

(6 citation statements)

References 11 publications

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“…Two participants had oral ulcers at the time of examination, and we found a positive relationship with the use of everolimus. Such a relationship has already been described elsewhere 36–39 . In this study, five patients were on everolimus and two of them had oral ulcers at the moment of clinical examination.…”

Section: Discussionsupporting

confidence: 76%

Oral findings in kidney transplant children and adolescents

Tuma

Andrade

Antunes

et al. 2022

Int J Paed Dentistry

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Kidney transplantation in children was first performed early in the 1970s, and the rate of success for this type of treatment increased over time until becoming the best therapeutic option for children and adolescents with terminal chronic renal failure (TCRF). The mortality rate of paediatric patients with TCRF on dialysis is seven times higher than that of kidney transplant patients. In addition, kidney transplantation leads to adequate skeletal growth, neurocognitive development and maturation and better quality of life in children and adolescents compared with those on dialysis. [1][2][3] In Brazil, the public healthcare system funds 95% of kidney transplantations, with the country ranking second in the world regarding such a procedure, second only to the United States. In 2019, a total of 6283 kidney transplantations were performed in Brazil, of which 310 were in patients younger than 18 years old. 4 According to the Brazilian Transplant Registry, congenital and hereditary diseases are the primary causes of renal failure in children from birth to 4 years old. Between the ages of 5 and 14 years, renal failure is mostly caused by hereditary conditions, nephrotic syndrome and systemic diseases, whereas the main underlying diseases are congenital anomalies of the kidneys and the urinary tract (CAKUT) (40.5%) and glomerulopathy (28%). 5

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Section: Discussionsupporting

confidence: 76%

Oral findings in kidney transplant children and adolescents

Tuma

Andrade

Antunes

et al. 2022

Int J Paed Dentistry

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“…Oral infections have been attributed to almost all immunosuppressive drugs [see, for example, papers (Habib et al , 2010; Mawardi et al , 2010; Sasaoka et al , 2010; Weng et al , 2011) regarding sirolimus, tacrolimus, everolimus, and mycophenolate mofetil, respectively].…”

Section: Oral Infectionsmentioning

confidence: 99%

“…Oral infections, reported since the 1970s (Greenberg and Cohen, 1977; Tyldesley et al , 1979), occur mainly during phases 1 and 2 and may present with ulceration that may be aphthous‐like and may be due to infections or drugs (including immunosuppressive agents such as sirolimus or other mTOR inhibitors) (Formica et al , 2003; Mahé et al , 2005; Chuang and Langone, 2007). They have been attributed to almost all immunosuppressive drugs [see, for example, papers (Habib et al , 2010; Mawardi et al , 2010; Sasaoka et al , 2010; Weng et al , 2011) regarding sirolimus, tacrolimus, everolimus, and mycophenolate mofetil, respectively]. Symptoms include discomfort and pain, which can be so severe as to impair eating, with consequent malnourishment and require local anesthetic applications (López‐Pintor et al , 2009; Vermeulen et al , 2010).…”

Section: Oral Infectionsmentioning

confidence: 99%

Orofacial diseases in solid organ and hematopoietic stem cell transplant recipients

Petti¹,

Polimeni

Berloco

et al. 2012

Oral Diseases

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“…1,3,10,17 Oral ulcerations and stomatitis have been considered a possible post-transplantation complication due to immunosuppressives such as tacrolimus, everolimus, and mycophenolate mofetil (MMF), however the reports on this topic are controversial. [18][19][20][21] An additional side effect of CsA is gingival enlargement, which usually appears within the first 3 months, affects the interdental papillae in the anterior region, while does not appear to affect edentulous areas. Gingival enlargement prevents the maintenance of the oral hygiene causing an increased susceptibility to caries, periodontal diseases, and infections.…”

Section: Oral Manifestations In Solid Organ Transplant Recipientsmentioning

confidence: 99%

Solid Organ Transplant Candidates and Recipients: Dentists’ Perspective

Gümrü

Tarçın

2021

Cumhuriyet Dental Journal

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In recent years, dental treatment need in organ transplant candidates and recipients increased in proportion to the increased number of organ transplantations due to advances in immunosuppressive drugs and medical surgical technology.For the transplant candidates and recipients, dental treatment usually requires standard practice procedures that apply to the management of the severely medically compromised patient. However, there are no guidelines, clinical trials or outcome assessments on appropriate dental treatment for these patient groups. Moreover, medicine often forgets dentistry, as there is no consensus among medical transplant specialists as to whether dental infections pose a risk to organ transplant candidates and recipients.The aim of this article is to briefly review the most common oral manifestations in solid organ transplant candidates and recipients, and to suggest a specific dental management protocol to guide medical and dental professionals for general dental management before and after solid organ transplantation.

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Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors

Abstract: Since these drugs are used widely in the pediatric transplantation population, this report serves to heighten awareness of this debilitating phenomenon, and to stress the importance of exercising caution when sirolimus and tacrolimus are administered in combination to pediatric patients.

Cited by 11 publications

References 11 publications

Oral findings in kidney transplant children and adolescents

Oral findings in kidney transplant children and adolescents

Orofacial diseases in solid organ and hematopoietic stem cell transplant recipients

Solid Organ Transplant Candidates and Recipients: Dentists’ Perspective

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