IgG or IgM anticardiolipin antibodies were present in the sera of 67% of 33 patients with Hansen's disease, in 53% of 30 patients with tuberculosis and in 50% of 16 patients with endocarditis. Despite the high frequency of these antibodies, no patient had a history of thrombosis or abortion. Anti-denatured DNA antibodies were tested in patients with tuberculosis and patients with Hansen's disease. Only in the latter group did we observe a statistically significant association between anticardiolipin and anti-denatured DNA antibodies. Anticardiolipin binding activity, however, could not be inhibited by preincubation of sera with a variable concentration of denatured DNA. These data suggest that: a) Anticardiolipin antibodies in infectious diseases do not necessarily participate in the pathogenesis of thrombotic or obstetric complications; b) Anti-denatured DNA and anticardiolipin antibodies in the population studied do not have a cross-reaction.
Aims: Autoimmune polyglandular syndrome type I (APS-I) is a rare condition of autosomal recessive and monogenic inheritance, which is characterized clinically by at least two signs of the classic triad: mucocutaneous candidosis, hypoparathyroidism, and Addison's disease. This study aims to report the oral manifestations of APS-I in a 42-year-old woman, who attended the Special Care Dentistry Center.
Methods and results:The patient presented with hypoparathyroidism, diabetes mellitus, and autoimmune hepatitis. Chronic hyperplastic candidosis (CHC) was the main oral manifestation and it was diagnosed based on clinical and cytologic characteristics. Microstomia, angular cheilitis, xerostomia, enamel hypoplasia, and microdontia were also present. Conclusions: CHC was treated with topical nystatin and oral fluconazole, resulting in a significant improvement of the lesions.
Kidney transplantation in children was first performed early in the 1970s, and the rate of success for this type of treatment increased over time until becoming the best therapeutic option for children and adolescents with terminal chronic renal failure (TCRF). The mortality rate of paediatric patients with TCRF on dialysis is seven times higher than that of kidney transplant patients. In addition, kidney transplantation leads to adequate skeletal growth, neurocognitive development and maturation and better quality of life in children and adolescents compared with those on dialysis. [1][2][3] In Brazil, the public healthcare system funds 95% of kidney transplantations, with the country ranking second in the world regarding such a procedure, second only to the United States. In 2019, a total of 6283 kidney transplantations were performed in Brazil, of which 310 were in patients younger than 18 years old. 4 According to the Brazilian Transplant Registry, congenital and hereditary diseases are the primary causes of renal failure in children from birth to 4 years old. Between the ages of 5 and 14 years, renal failure is mostly caused by hereditary conditions, nephrotic syndrome and systemic diseases, whereas the main underlying diseases are congenital anomalies of the kidneys and the urinary tract (CAKUT) (40.5%) and glomerulopathy (28%). 5
Aims
The final diagnosis of oral mucosal ulcerations in solid organ transplant recipients represents a challenge. We describe a unique case of oral ulceration related to mycophenolate mofetil (MMF) toxicity, 11 years after kidney transplantation, whose dose reduction was sufficient to resolve it.
Methods and results
A 54‐year‐old female patient, who underwent kidney transplantation 11 years ago, presents multiple ulcers on the buccal mucosa bilaterally, soft palate and tongue dorsum, for 8 months, with moderate pain. The diagnosis of oral ulcerations associated with MMF therapy was assumed by excluding infection and malignancy diagnosis. After MMF dose reduction, the oral ulcers healed utterly.
Conclusions
MMF toxicity manifested as oral ulcers. Reduction or discontinuation of MMF therapy should be considered in a patient with refractory oral ulcers and a negative workup for other causes.
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