Severe anaemia in the immediate post-partum period. Clinical practice and value of intravenous iron

Broche, D.-E.; Gay, Christian; Armand-Branger, S.; Grangeasse, L.; Terzibachian, J.-J.

doi:10.1016/s0301-2115(05)80403-8

Cited by 17 publications

(19 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Iron-sucrose appears to be effective because it is rapidly removed from the plasma and used for erythropoiesis. The finding is supported by the study done by Broche et al [9]. in which a mean increase in Hb of 1.9 g/dl within 7 days was obtained with intravenous iron and of 3.1 g/dl within 14 days without any serious side effect.…”

Section: Discussionsupporting

confidence: 71%

Intravenous Iron in Postpartum Anemia

Jain

Palaria

Jha

2013

J Obstet Gynecol India

View full text Add to dashboard Cite

Objective To compare effectiveness of intravenous ironsucrose versus oral ferrous fumarate in postpartum anemia. Methods In this study, 40 women with postpartum anemia with hemoglobin (Hb) less than 8 g/dl within 48 h postpartum were randomised into two groups. Group I consisted of 20 women who received 300-600 mg of intravenous iron-sucrose every alternate day for 3 days. Group II consisted of 20 women who were given 300 mg ferrous fumarate orally daily for 14 days. Results On day 14, the increase in mean Hb level in group I was 2.4 g/dl in comparison to 1.2 g/dl in group II. Women in group I had significantly higher mean Hb values on days 7 and 14 (p \ 0.001) than women in group II. Conclusion These results suggest that intravenous ironsucrose increases the Hb level more rapidly than oral ferrous fumarate in postpartum anemia without any serious side effects.

show abstract

Section: Discussionsupporting

confidence: 71%

Intravenous Iron in Postpartum Anemia

Jain

Palaria

Jha

2013

J Obstet Gynecol India

View full text Add to dashboard Cite

show abstract

“…[4][5][6] Most of the women belonged to lower socio-economic class taking diet deficient in essential nutrients and minerals and therefore more than 60% women in our study had anaemia. 7 Multiparty had been an important risk factor for postpartum anaemia because repeated pregnancies result in depletion of iron stores.…”

Section: Discussionmentioning

confidence: 71%

“…7 Multiparty had been an important risk factor for postpartum anaemia because repeated pregnancies result in depletion of iron stores. 6,7 The majority of patients in all studies were illiterate or educated up to primary school, which could be due to lower socioeconomic status. Due to lack of education, the patients were not aware of the significance of prenatal care and good nutritious diet.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Intravenous versus oral iron therapy in treatment of postpartum anaemia

Agarwal

Sharma

2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

INTRODUCTIONPostpartum anaemia is a common problem throughout the world and for most women is self limiting, resolving within a week. For some women however, particularly in resource-poor countries, it is a major cause of maternal morbidity and mortality.1 Postpartum haemoglobin (Hb) levels of <10 g/dl are observed in up to 30% of women, with more severe anaemia (Hb < 8g/dl) seen in 10%. Iron deficiency is the principal cause. This is partly attributable to an iron deficit during pregnancy, caused by the increased iron demands of the fetoplacental unit and an increased maternal red cell mass. 2Irrespective of mode of delivery, blood loss is a contributing factor, with 5% of deliveries involving loss of more than 1L. It appears to be higher in unfavorable socioeconomic conditions. The symptoms of postpartum anaemia vary and may include breathlessness, fatigue, palpitations, dizziness, maternal infections particularly of the urinary tract, lactation failure and prolonged hospital stay depending on the severity of blood loss and related anaemia. It has also been shown to be strongly associated with depression, stress and cognitive function in the postpartum period and may result in difficulty for the ABSTRACT Background: Postpartum iron deficiency anaemia (IDA) is common in women. Most women are treated with either oral iron supplementation or blood transfusion. Hence, the aim of our study was to compare the effect of treatment with either oral ferrous sulphate or intravenous ferrous sucrose on postpartum IDA. Methods: 100 postpartum women with proven iron deficiency anaemia with hemoglobin <9gm/dl and serum ferritin <15 µgm/l were included in the study. They were randomized to receive either oral ferrous sulphate 200 mg twice daily for 6 weeks (group 1) or intravenous ferrous sucrose 200 mg, two to three doses given on alternate days (group 2). Total iron deficit was calculated using a standard formula. Target hemoglobin was 11 gm/dl. Results were analysed by the students t-test and chi-square test. Hemoglobin, hematocrit, red cell indices and ferritin were measured on day 2-3, 1-2 weeks and 6 weeks postpartum Results: By 1-2 weeks, hemoglobin level in women treated with intravenous iron had risen from 7.81±0.849 to 9.88±0.760 gm/dl which was more than those treated with oral iron (p<0.01); although by 6 weeks, there was no significant difference between the two groups. Ferritin levels rose rapidly in those treated with intravenous iron and remained significantly higher than in those treated with oral iron (p<0.01). Conclusions: Intravenous iron sucrose increases the hemoglobin level more rapidly than oral ferrous sulphate in women with postpartum IDA. It also replenishes iron stores more rapidly.

show abstract

“…In addition, an inflammatory reaction can occur, particularly following surgically assisted deliveries and cesarean section, leading to iron sequestration in the macrophages and decrease of intestinal absorption so that administered iron is not available for hemopoiesis. 4,5 Iron sucrose complex is a widely used and safe molecule, which has become major interest to prevent functional iron deficiency, and numerous reports show the effectiveness and safety of the iron sucrose complex. 12,14 Good tolerance to this iron formulation is partly due to the low allergic effect of the sucrose and partly due to slow release of the elementary iron from the complex.…”

Section: Introduction Introduction Introduction Introductionmentioning

confidence: 99%

Intravenous Iron Therapy versus Oral Iron in Postpartum Patients in Rural Area

Verma¹,

Inamdar²,

Malhotra³

2011

Journal of South Asian Federation of Obstetrics and Gynaecology

View full text Add to dashboard Cite

Objectives: The aim of this study is to evaluate the efficiency and safety of intravenous iron sucrose complex and comparison with oral iron therapy in postpartum period in rural area. Materials and methods:It is a prospective, randomized, hospital-based clinical study carried out in over 150 patients, having Hb < 8 mg/dl after 24 hours of delivery. 600 to 800 mg iron sucrose has been given in divided doses, 200 mg on alternate day in 100 ml of normal saline to half of the patients whereas rest of the patients given 200 mg bd dose of ferrous sulphate by oral route for one month. Data was collected after 1st, 2nd, 3rd and 4th week for the hemoglobin estimation and assessment of the impact of intravenous iron sucrose treatment on the postpartum parameters. Results:The mean Hb was significantly increased in the intravenous iron sucrose group in 7 days (7.42 ± 1.04 gm/dl to 9.8 ± 0.76 gm/dl) of treatment but there was no change observed in mean Hb in the patients treated with oral ferrous sulphate. Women treated with intravenous iron sucrose has shown significantly higher Hb on day 7, day 15 and day 30 as compared to the women those were treated with oral iron (p < 0.0001). Conclusion:Overall intravenous iron sucrose appears to be an effective mode of treatment in postpartum patients with no serious side effects and associated with faster recovery in shorter duration of hospital stay than oral iron treatment.

show abstract

Severe anaemia in the immediate post-partum period. Clinical practice and value of intravenous iron

Cited by 17 publications

References 6 publications

Intravenous Iron in Postpartum Anemia

Intravenous Iron in Postpartum Anemia

Intravenous versus oral iron therapy in treatment of postpartum anaemia

Intravenous Iron Therapy versus Oral Iron in Postpartum Patients in Rural Area

Contact Info

Product

Resources

About