Severe Allergic Reaction to an Intra‐urethral Preparation Containing Chlorhexidine

Anaphylaxis to the chlorhexidine component of Instillagel®: a case series

“…4 Anaphylaxis to a chlorhexidinecontaining gel was first reported in 1992. 5 Since then, several cases have been described predominately in the urological literature. 6 -10 All the previous reported cases of anaphylaxis to the chlorhexidine component of a lubricant were reported in male patients.…”

Chlorhexidine‐induced anaphylaxis in surgical patients: a review of the literature

“…Numerous authors have noticed, retrospectively, that patients who suffered CHL‐induced anaphylaxis had subtle hypersensitivity reactions that were not investigated prior to full blown anaphylaxis. The most common being urticaria or an erythematous rash . In the perioperative setting, these symptoms are often dismissed, poorly documented and not followed up, culminating in missed opportunities to diagnose CHL allergy and avoid anaphylaxis .…”

The risk for endocarditis in dental practice

“…Despite these conflicting results and the potential risks, the American Heart Association guidelines propose the use of a chlorhexidine hydrochloride rinse prior to invasive procedures (26,28). Confusion concerning the benefit from antibacterial mouthrinses mandates the need for supporting data before antibacterial rinses are suggested for widespread use, as the cost, side effects and false sense of secur-ity appear to outweigh any known benefit (16,81,89). Clearly, one should never assume that mouthrinses are in any manner a substitute for systemic antibiotics.…”