Severe acute tumor lysis syndrome in patients with germ-cell tumors

Feres, Guilherme Alvarenga; Salluh, Jorge I.; Ferreira, Carlos Gil; Soares, Márcio

doi:10.4103/0970-1591.44267

Cited by 10 publications

(14 citation statements)

References 6 publications

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“…8 Adequate hydration and the administration of allopurinol and rasburicase are recommended, but these preventive measures might be inadequate; one case describes acute renal failure occurring despite their use. 9 Currently, there is also no effective prevention for CS.…”

Section: Discussionmentioning

confidence: 99%

Advanced testicular cancer associated with life-threatening tumour lysis syndrome and choriocarcinoma syndrome

Kobatake

Katô

Mita

2015

CUAJ

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Tumour lysis syndrome (TLS) and choriocarcinoma syndrome (CS) are severe complications of chemotherapy for testicular cancer. They are rare, but can be life-threatening. A 37-year-old man complaining of persisting cough was referred to our hospital. A computed tomography (CT) scan revealed huge tumours that occupied the peritoneal cavity, with multiple lung, liver, and para-aortic metastases. Although there was no abnormal finding in the testes, serum testicular tumor markers showed marked elevation. A CT-guided biopsy for the peritoneal tumours revealed extragonadal germ cell tumour (GCT), including yolk sac tumour and choriocarcinoma. Chemotherapy with bleomycin, etoposide, and cisplatin (BEP) was started after admission. The morning after the beginning of BEP, the patient developed hemorrhagic shock, in addition to acute pulmonary and renal failure, because of TLS and massive hemorrhage at bilateral lung metastases. He was intubated and resuscitated. Despite appropriate therapy, his renal function did not recover and hemodialysis was started. The patient eventually died of severe respiratory distress syndrome and infection. To our knowledge, this is the first case report of TLS and CS as complications of hemorrhage at the lung metastases of advanced testicular cancer leading to death.

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Section: Discussionmentioning

confidence: 99%

Advanced testicular cancer associated with life-threatening tumour lysis syndrome and choriocarcinoma syndrome

Kobatake

Katô

Mita

2015

CUAJ

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“…One of the most critical and life-threatening adverse conditions of chemotherapy needing immediate intervention is tumour lysis syndrome. It results from the massive and abrupt destruction and lysis of malignant cells and subsequent release of intracellular ions and metabolites into the bloodstream leading to hyperuricemia, hyperphosphatemia, hypocalcemia, and hyperkalemia [57, 58]. This syndrome is accompanied by renal failure and metabolic acidosis increasing the risk of death [57].…”

Section: Typical Side Effects Of Chemotherapymentioning

confidence: 99%

“…It results from the massive and abrupt destruction and lysis of malignant cells and subsequent release of intracellular ions and metabolites into the bloodstream leading to hyperuricemia, hyperphosphatemia, hypocalcemia, and hyperkalemia [57, 58]. This syndrome is accompanied by renal failure and metabolic acidosis increasing the risk of death [57]. Although the tumour lysis syndrome is most frequently observed in patients with haematologic malignancies, it may also occur in solid tumours [57, 58].…”

Section: Typical Side Effects Of Chemotherapymentioning

confidence: 99%

“…This syndrome is accompanied by renal failure and metabolic acidosis increasing the risk of death [57]. Although the tumour lysis syndrome is most frequently observed in patients with haematologic malignancies, it may also occur in solid tumours [57, 58]. These malignancies share the characteristics of a high proliferative rate, large tumour burden, or high sensitivity to cytotoxic therapy and in principle, any tumour that is highly responsive to chemotherapeutic drugs, particularly if the cancer cells die through the necrotic pathway, can give rise to this severe metabolic syndrome [2, 58].…”

Section: Typical Side Effects Of Chemotherapymentioning

confidence: 99%

See 1 more Smart Citation

Chemotherapy and Dietary Phytochemical Agents

Sak¹

2012

Chemotherapy Research and Practice

234

192

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Chemotherapy has been used for cancer treatment already for almost 70 years by targeting the proliferation potential and metastasising ability of tumour cells. Despite the progress made in the development of potent chemotherapy drugs, their toxicity to normal tissues and adverse side effects in multiple organ systems as well as drug resistance have remained the major obstacles for the successful clinical use. Cytotoxic agents decrease considerably the quality of life of cancer patients manifesting as acute complaints and impacting the life of survivors also for years after the treatment. Toxicity often limits the usefulness of anticancer agents being also the reason why many patients discontinue the treatment. The nutritional approach may be the means of helping to raise cancer therapy to a new level of success as supplementing or supporting the body with natural phytochemicals cannot only reduce adverse side effects but improve also the effectiveness of chemotherapeutics. Various plant-derived compounds improve the efficiency of cytotoxic agents, decrease their resistance, lower and alleviate toxic side effects, reduce the risk of tumour lysis syndrome, and detoxify the body of chemotherapeutics. The personalised approach using various phytochemicals provides thus a new dimension to the standard cancer therapy for improving its outcome in a complex and complementary way.

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“…These tumors are characterized by high mitotic rates and rapid proliferation, often resulting in bulky tumor burden. Tumor lysis syndrome has been reported in association with germ cell tumors, typically following chemotherapy ( Feres et al, 2008 ). Herein, we present the case of tumor lysis syndrome following low-dose, localized palliative radiation prior to chemotherapy exposure in a patient with a metastatic germ cell tumor.…”

Section: Introductionmentioning

confidence: 99%