Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccination in Pregnancy

Shanes, Elisheva D; Otero, Sebastián; Mithal, Leena B.; Mupanomunda, Chiedza; Miller, Emily S.; Goldstein, Jeffery A.

doi:10.1097/aog.0000000000004457

Cited by 75 publications

(80 citation statements)

References 25 publications

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“…The response was increased after a booster was given. 11,13 Although vast majority of pregnant women had IgG seroconversion, IgM seroconversions were observed in a minority of pregnant women. 18 After vaccination, IgG against S1, S2 and RBD formed whilst IgG against S1, S2, RBD and N protein formed following natural infections.…”

Section: Main Findingmentioning

confidence: 99%

“…While for the IgM levels are 4.1±13.2 AU and 0.19±0.12 AU, respectively (p=0.001). 13 Among pregnant women that received two vaccine doses, anti-spike-protein IgG concentration median is 319 (211-1033) AU/mL and anti-RBD-Specific IgG concentration median is 11150 (6154-17575) AU/mL. 17 Meanwhile, in two women that only received one dose of vaccine, the anti-spike-protein IgG concentrations are 50 AU/mL and 52 AU/m; and the anti-RBD-Specific IgG concentrations are 293 AU/mL and 1137 AU/mL.…”

Section: Maternal Igg Between Vaccinated Vs Pcr-positivementioning

confidence: 99%

“…19 Maternal antibody response has been described formed following vaccination. [11][12][13][14][15]17,18,20 Through vaccination, antibody response was formed rapidly; while through vaccination it was formed gradually. 20 The number of IgG and IgM against SARS-CoV-2 were significantly increased after vaccination.…”

Section: Main Findingmentioning

confidence: 99%

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Covid-19 Vaccination in Pregnancy: A Systematic Review

Pratama

Wafa

Budi

et al. 2021

Preprint

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Objective: Pregnancy is a risk factor for severe Covid-19. Looking for safe vaccines that evoke protective maternal and fetal antibody response is important. Methods: We searched from registries (ClinicalTrials.gov, the WHO Clinical Trial Registry, and the EU Clinical Trial Registry) and databases (MEDLINE, ScienceDirect, Cochrane Library, Proquest, and Springer) up until June 20, 2021. Articles were selected based on inclusion and exclusion criteria after duplicates were removed. Infection rate, maternal antibody response, placental antibody transfer, and adverse events were described. This systematic review was performed with quality assessment and semi-quantitative synthesis according to PRISMA guidelines. Results: Twelve observational studies with a total of 40.509 pregnant women included. The mRNA based vaccines (Pfizer-BioNTech and Moderna) can prevent future SARS-CoV-2 infections (p=0.0004). Both vaccines did not affect pregnancy, delivery, and neonatal outcomes. The most commonly encountered adverse reactions are injection-site pain, fatigue, and headache but only transient. Antibody responses were rapid after the prime dose of vaccines. After booster, antibody responses were higher and associated with better placental antibody transfer. Longer intervals between first vaccination dose and delivery were also associated with higher antibody fetal IgG and better antibody transfer ratio. Conclusions: The Pfizer-BioNTech and Moderna vaccines are efficacious for preventing future SARS-CoV-2 infections. These vaccines can be considered as a safe option for pregnancy and their fetus. Two doses of vaccines were recommended for more robust maternal and fetal antibody responses. Longer latency was associated with higher fetal antibody responses.

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Section: Main Findingmentioning

confidence: 99%

Section: Maternal Igg Between Vaccinated Vs Pcr-positivementioning

confidence: 99%

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Covid-19 Vaccination in Pregnancy: A Systematic Review

Pratama

Wafa

Budi

et al. 2021

Preprint

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“…Las mujeres tuvieron una buena respuesta a las vacunas, produciendo los niveles necesarios de anticuerpos neutralizantes y células inmunitarias conocidas como células T de memoria, que pueden ofrecer una protección más duradera. La investigación también indica que las vacunas podrían ofrecer protección a los bebés nacidos de madres vacunadas (37,38) .…”

Section: La Vacuna Covid-19 En La Mujer Embara-zada La Mujer Lactante Y El Neonatounclassified

La incógnita del coronavirus - Lo nuevo sobre su acción en la gestante y su bebe

Romero¹

2021

Rev peru ginecol obstet.

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El virus SARS-CoV-2 sigue reproduciéndose velozmente y muestra variantes más infecciosas. La segunda ola de la enfermedad va apaciguándose en Europa y Estados Unidos de América del Norte, menos en América del Sur. En el Perú, las cifras de fallecidos han sido sinceradas a más del doble, encontrándose mayor mortandad en los hombres y en los mayores de 70 años. Se ha corroborado en el mundo que la gestante sufre una enfermedad más severa -a veces con un proceso similar a la preeclampsia-, con más posibilidad de muerte que la mujer no gestante y mayor muerte fetal y prematuridad. Las vacunas iniciales elaboradas en los EE UU y Europa están siendo efectivas en disminuir las infecciones, hospitalizaciones y muertes en los países donde la vacunación ha avanzado más rápido. Está siendo administrada en gestantes sin efectos secundarios mayores, recomendándoseles se vacunen para evitar la infección severa. Mientras tanto, no se conoce la duración de la inmunidad dada por la infección COVID-19 y por la vacuna. Se está considerando una tercera dosis de refuerzo y el cambio de marca en los vacunados. Y se está en espera de una tercera ola de infecciones debido a la aparición de las variantes brasilera e india (delta).

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“…Their analysis demonstrated (1) no difference in the rate of accidental pregnancies between vaccinated and unvaccinated women and (2) no increased miscarriage rate [ 5 ]. Another recent study could not find evidence for an increased frequency of preterm delivery or fetal loss in women vaccinated during their pregnancy, suggesting that COVID-19 vaccines do not result in pregnancy disruption [ 8 ].…”

mentioning

confidence: 99%