Severe Acute Respiratory Syndrome Coronavirus 2 Is Detected in the Gastrointestinal Tract of Asymptomatic Endoscopy Patients but Is Unlikely to Pose a Significant Risk to Healthcare Personnel

Cherne, Michelle D.; Gentry, Andrew; Nemudraia, Anna; Nemudryy, Artem; Hedges, Jodi F.; Walk, Heather; Blackwell, Karlin; Snyder, Deann T.; Jerome, Maria; Madden, Wyatt; Hashimi, Marziah; Sebrell, Thomas A.; King, David B.; Plowright, Raina K.; Jutila, Mark A.; Wiedenheft, Blake; Bimczok, Diane

doi:10.1016/j.gastha.2022.06.002

Cited by 4 publications

(12 citation statements)

References 34 publications

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“…Evidence indicates active SARS-CoV-2 replication in enterocytes, leading to gut infection in acute COVID-19 cases [3][4][5][6][7][8][9][10][11][12]. Consequently, stringent protective measures are recommended during endoscopic procedures, especially for COVID-19 patients, to prevent viral transmission to healthcare providers [22].…”

Section: Discussionmentioning

confidence: 99%

“…Results showed a low incidence of persistent SARS-CoV-2 gut infection-only one biopsy from the unknown infection status group and three from the confirmed group tested positive. Moreover, no viable SARS-CoV-2 virions were isolated from the samples, and the virus and its RNA were found to be inactivated entirely within 24 hours of exposure to colonic fluids [9].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Persistent gut infection by SARS-CoV-2 has been reported, with viral RNA and nucleocapsid proteins detected in surgical samples from the stomach, colon, intestine, gallbladder, bile, and peritoneal fluid months post-infection [13][14][15]. These viral components have also been identified in endoscopic biopsies from the small bowel and colon long after COVID-19 resolution [5,9,16,17].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…COVID-19 extends beyond the respiratory system, with documented effects on other systems, notably the gastrointestinal tract. More than 10% of patients have reported symptoms such as nausea, vomiting, and diarrhea during acute illness, occasionally preceding the onset of respiratory symptoms [3][4][5][6][7][8][9]. Additionally, viral RNA has been detected in the feces of approximately 50% of COVID-19 patients, regardless of Gastrointestinal (GI) symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…Evidence shows that viral particles can persist in different human tissues, including neural, cardiac, adipose, and gut tissues, for an extended period after primary COVID-19. This persistence has been associated with the phenomenon known as "long COVID-19" [5,9,[13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Incidence of persistent SARS-CoV-2 gut infection in patients with a history of COVID-19: Insights from endoscopic examination

Hany,

Sheta,

Talha

et al. 2023

Endosc Int Open

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Background: Gut affection is common during acute COVID-19, and persistent SARS-CoV-2 gut infection has been reported months after the initial infection, potentially linked to long COVID syndrome. This study tested the incidence of persistent gut infection in patients with a history of COVID-19 undergoing endoscopic examination. Methods: Endoscopic biopsies were prospectively collected from patients with previous COVID-19 infection undergoing upper or lower gastrointestinal endoscopy (UGE or LGE). Immunohistochemistry was used to detect the presence of persistent SARS-CoV-2 nucleocapsid proteins. Results: A total of 166 UGEs and 83 LGE were analyzed. No significant differences were observed between patients with positive and negative immunostaining regarding the number of previous COVID-19 infections, time since the last infection, symptoms, or vaccination statuses. The incidence of positive immunostaining was significantly higher in UGE biopsies than in LGE biopsies (37.34% vs. 16.87%, p = .002). Smokers showed a significantly higher incidence of positive immunostaining in the overall cohort and UGE and LGE subgroups (p < .001). Diabetic patients exhibited a significantly higher incidence in the overall cohort (p = .002) and UGE subgroup (p = .022), with a similar trend observed in the LGE subgroup (p = .055). Conclusion: Gut mucosal tissues can act as a long-term reservoir for SARS-CoV-2, retaining viral particles for months following the primary COVID-19 infection. Smokers and individuals with diabetes may be at an increased risk of persistent viral gut infection. These findings provide insights into the dynamics of SARS-CoV-2 infection in the gut and have implications for further research.

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Section: Discussionmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Incidence of persistent SARS-CoV-2 gut infection in patients with a history of COVID-19: Insights from endoscopic examination

Hany,

Sheta,

Talha

et al. 2023

Endosc Int Open

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Making waves: Integrating wastewater surveillance with dynamic modeling to track and predict viral outbreaks

et al. 2023

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Infection, Dysbiosis and Inflammation Interplay in the COVID Era in Children

Ailioaie

Litscher³

2023

IJMS

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For over three years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children and adolescents has generated repercussions, especially a few weeks after infection, for symptomatic patients who tested positive, for asymptomatic ones, or even just the contacts of an infected person, and evolved from severe forms such as multisystem inflammatory syndrome in children (MIS-C) to multifarious clinical manifestations in long COVID (LC). Referred to under the umbrella term LC, the onset of persistent and highly heterogeneous symptoms such as fatigue, post-exertion malaise, cognitive dysfunction, and others have a major impact on the child’s daily quality of life for months. The first aim of this review was to highlight the circumstances of the pathophysiological changes produced by COVID-19 in children and to better understand the hyperinflammation in COVID-19 and how MIS-C, as a life-threatening condition, could have been avoided in some patients. Another goal was to better identify the interplay between infection, dysbiosis, and inflammation at a molecular and cellular level, to better guide scientists, physicians, and pediatricians to advance new lines of medical action to avoid the post-acute sequelae of SARS-CoV-2 infection. The third objective was to identify symptoms and their connection to molecular pathways to recognize LC more easily. The fourth purpose was to connect the triggering factors of LC with related sequelae following acute SARS-CoV-2 injuries to systems and organs, the persistence of the virus, and some of its components in hidden reservoirs, including the gut and the central nervous system. The reactivation of other latent infectious agents in the host’s immune environments, the interaction of this virus with the microbiome, immune hyperactivation, and autoimmunity generated by molecular mimicry between viral agents and host proteins, could initiate a targeted and individualized management. New high-tech solutions, molecules, probiotics, and others should be discovered to innovatively solve the interplay between RNA persistent viruses, microbiota, and our immune system.

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Severe Acute Respiratory Syndrome Coronavirus 2 Is Detected in the Gastrointestinal Tract of Asymptomatic Endoscopy Patients but Is Unlikely to Pose a Significant Risk to Healthcare Personnel

Cited by 4 publications

References 34 publications

Incidence of persistent SARS-CoV-2 gut infection in patients with a history of COVID-19: Insights from endoscopic examination

Incidence of persistent SARS-CoV-2 gut infection in patients with a history of COVID-19: Insights from endoscopic examination

Making waves: Integrating wastewater surveillance with dynamic modeling to track and predict viral outbreaks

Infection, Dysbiosis and Inflammation Interplay in the COVID Era in Children

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