Incidence of persistent SARS-CoV-2 gut infection in patients with a history of COVID-19: Insights from endoscopic examination

Hany, Mohamed; Sheta, Eman; Talha, Ahmed; Anwar, Medhat; Selima, Mohamed; Gaballah, Muhammad; Zidan, Ahmed; Ibrahim, Mohamed; Agayby, Ann Samy Shafiq; Abouelnasr, Anwar Ashraf; Samir, Mohamed; Torensma, Bart

doi:10.1055/a-2180-9872

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Lapa et al reported that in patients who survived and recovered after SARS-CoV-2 infection, hair loss, obesity, memory loss and hypercholesterolemia were observed 3-6 months later, in the period they named as "Post-covid Syndrome" [38]. A recent study conducted by Hany et al showed that virus particles SARS-CoV-2 form long-term viral reservoirs in the gastrointestinal tract mucosa [39]. The potential for SARS-CoV-2 to create a long-term reservoir and cause damage in the gastrointestinal (GI) mucosa, coupled with one of the entry routes of SARS-CoV-2 being the oral cavity, suggests the possibility of long-term infection in the oral region.…”

Section: Discussionmentioning

confidence: 99%

Has the Covid-19 pandemic altered the frequency of periodontitis? An analysis conducted using Google Trends.

Üner,

İzol

2024

Preprint

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Background SARS-CoV-2 infection causes permanent damage to various organs and tissues in humans in the long term. The aim of this study is to compare the frequency of searches for the word "periodontitis" on the internet in the period after SARS-CoV-2 infection and in the previous period, using GT (Google Trends), and in this way to indirectly determine whether there is a relationship between SARS-CoV-2 infection and periodontitis. Methods Using the GT online tool in randomly selected countries and around the world, the word "periodontitis" and the word equivalent to the word "periodontitis" in the language of that country were scanned for a 4-year period before and after the SARS-CoV-2 pandemic and compared. Results The M (Mean) of the RSV data of the word "periodontitis" worldwide in the pre-Covid period (between 2015–2019) in Google Trends was detected as 64.11 ± 7.85, MD (Median) was 63, and min and max were 44 and 100, respectively. Conclusion In this study, it has been determined that the level of internet searches for the word "periodontitis" has increased compared to the pre-SARS-CoV-2 period since the first occurrence of the SARS-CoV-2 virus worldwide. This study may provide a causal basis for subsequent clinical studies on this subject.

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Section: Discussionmentioning

confidence: 99%

Has the Covid-19 pandemic altered the frequency of periodontitis? An analysis conducted using Google Trends.

Üner,

İzol

2024

Preprint

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“…At autopsy, SARS-CoV-2 RNA was found throughout the body, including brain tissue, for up to 230 days after onset of symptoms. Hany et al [28] recently reported that SARS-CoV-2 can form long-term viral reservoirs in the GI tract’s mucosa.…”

Section: Etiology Of Long Covidmentioning

confidence: 99%

Long COVID’s Impact on Patients, Workers, & Society: A review

Kavanagh,

Cormier,

Pontus

et al. 2024

Medicine

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The incidence of long COVID in adult survivors of an acute SARS-CoV-2 infection is approximately 11%. Of those afflicted, 26% have difficulty with day-to-day activities. The majority of long COIVD cases occur after mild or asymptomatic acute infection. Children can spread SARS-CoV-2 infections and can also develop long-term neurological, endocrine (type I diabetes), and immunological sequelae. Immunological hypofunction is exemplified by the recent large outbreaks of respiratory syncytial virus and streptococcal infections. Neurological manifestations are associated with anatomical brain damage demonstrated on brain scans and autopsy studies. The prefrontal cortex is particularly susceptible. Common symptoms include brain fog, memory loss, executive dysfunction, and personality changes. The impact on society has been profound. Fewer than half of previously employed adults who develop long COVID are working full-time, and 42% of patients reported food insecurity and 20% reported difficulties paying rent. Vaccination not only helps prevent severe COVID-19, but numerous studies have found beneficial effects in preventing and mitigating long COVID. There is also evidence that vaccination after an acute infection can lessen the symptoms of long COVID. Physical and occupational therapy can also help patients regain function, but the approach must be “low and slow.” Too much physical or mental activity can result in post-exertional malaise and set back the recovery process by days or weeks. The complexity of long COVID presentations coupled with rampant organized disinformation, have caused significant segments of the public to ignore sound public health advice. Further research is needed regarding treatment and effective public communication.

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Identification of SARS-CoV-2 Persistent Intestinal Epithelial Syndrome (SPIES) as a Novel Disease Entity using Clinical, Histologic, and RNA Programmatic Data

Wallach,

Soliman,

Agboola

et al. 2024

Preprint

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Abstract“Long COVID” (LC) remains an ongoing issue and one which has created a substantial burden of disease. Gastrointestinal LC is relatively poorly understood. In this study we characterize a syndrome of persistent SARS-CoV2 viral material via clinical and histologic data, and RNA sequencingMethodsWe reviewed patients aged 5-22 years with an esophagogastroduodenoscopy (EGD) for gastrointestinal (GI) symptoms from 6/2020-6/2023, excluding patients with known histologic disease. Biopsies were sent for immunohistochemical staining. Clinical data was collected. Duodenal, ileal, cecal, and sigmoid colon samples were stained for SARS-CoV-2 using a SARS-CoV-2 nucleocapsid antibody. Slides were reviewed by a blinded pathologist. 8 patients with known duodenal SARS-CoV-2 nucleocapsid antigen (SC-NA) positivity and 8 demographically matched IBS matched patients from prior to 2020 were identified for RNA sequencing comparison. Results were compared with public data from the Gene Expression Omnibus (GEO) data repository for intestinal tissue with IBS and epithelial tissues with active SARS-CoV2 infection.ResultsOf 30 patients, fifteen (50%) were identified to have positive SC-NA. 3 (20%) had received at least a single SARS-CoV2 vaccine in the + cohort, and 8 (53.3%) in the - (P=0.05). Primary symptoms were pain (86%, nausea (66.6%), and weight loss (60%). 37.5% of patients with colonic SC-NA displayed hematochezia. 33% of + patients showed elevated ESR/CRP. Mean + calprotectin was 317.3 vs. 156.4 (p=0.2). 11/15 (73.3%) +SC-NA had large lymphoid aggregates (LLA) (p = 0.00338). RNA expression was consistent with known acute SARS-CoV2 infection. Hub network analysis showed a tight shift in RNA expression centered around HSPE-1p26, with involvement of known SARS-CoV2 immune mediators like NEAT1. DGE comparative analysis with IBS and acute SARS-CoV2 infection showed higher overlap with acute infection vs. IBS. FGSEA analysis with the same source data demonstrated the same.ConclusionsOur findings establish a syndrome mediated by persistent viral infection (SARS-CoV2 Persistent Intestinal Epithelial Syndrome (SPIES)). We hypothesize that persistent sparse infection drives ongoing immune signaling altering movement and function, creating epithelial and movement effects overlapping with DGBI and IBD

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Incidence of persistent SARS-CoV-2 gut infection in patients with a history of COVID-19: Insights from endoscopic examination

Cited by 3 publications

References 37 publications

Has the Covid-19 pandemic altered the frequency of periodontitis? An analysis conducted using Google Trends.

Has the Covid-19 pandemic altered the frequency of periodontitis? An analysis conducted using Google Trends.

Long COVID’s Impact on Patients, Workers, & Society: A review

Identification of SARS-CoV-2 Persistent Intestinal Epithelial Syndrome (SPIES) as a Novel Disease Entity using Clinical, Histologic, and RNA Programmatic Data

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