Severe acute pancreatitis following endoscopic biopsy of the minor duodenal papilla

The role of endoscopy in ampullary and duodenal adenomas

“…Pancreatitis has been reported after biopsies of the papilla, and, therefore, care should be taken to obtain tissue away from the pancreatic duct orifice. 18 Diagnostic (adenoma and carcinoma diagnosis) rates for ampullary biopsies of 45% to 80% have been reported, with false-negative results in 16% to 60% of patients with carcinoma. 9,[19][20][21][22][23][24][25][26] The rate of false-negative biopsies may be minimized by sampling within 10 days after sphincterotomy 27,28 or obtaining at least 6 biopsy specimens.…”

Acute pancreatitis after endoscopic biopsy of the minor duodenal papilla in an individual with pancreas divisum

“…Therefore papillary edema due to endoscopic biopsy may obstruct the pancreatic duct causing acute pancreatitis. Ductal obstruction can easily develop as a result of relative stenosis of the minor papilla in cases of pancreas divisum [2,3]. In the case reported here, the opening of the minor papilla distinctly resembled a polyp.…”

Acute Pancreatitis Following Endoscopic Ampullary Biopsies without Attempted Cannulation of the Ampulla of Vater

“…Another case of severe acute pancreatitis was attributed to endoscopic biopsies of the minor papilla in a patient with pancreas divisum and liver metastases due to colon cancer [4]. The third was also a case of severe pancreatitis with formation of a large pancreatic walled-off necrosis that was managed with ultrasonography-guided drainage [5].…”