Severe Acute Mountain Sickness Complicated by Multiple Organ Dysfunction Syndrome

Zhou, Qian

doi:10.4172/2165-7548.1000113

Cited by 4 publications

(4 citation statements)

References 28 publications

(26 reference statements)

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“…Since early positive diagnosis of severe traumatic MODS may be difficult, the MOF mortality may be falsely regarded as the MODS mortality, which may be the reason for the high mortality (>80%) for traumatic MODS (10). Early diagnosis of MODS, allowing the best window of opportunity for treatment of MODS is an important measure to reduce the fatality rate of traumatic ICU patients (11,35).…”

Section: Discussionmentioning

confidence: 99%

Clinical application of a novel diagnostic scheme including pancreatic β‑cell dysfunction for traumatic multiple organ dysfunction syndrome

et al. 2017

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A novel diagnostic scheme that includes pancreatic β‑cell dysfunction analysis for the diagnosis of traumatic multiple organ dysfunction syndrome (MODS) was investigated to assist in the early diagnosis and detection of MODS. Early intervention and treatment of MODS has been associated with a reduced mortality rate. A total of 2,876 trauma patients (including patients post‑major surgery) were admitted to the intensive care unit of the authors' hospital between December 2010 and December 2015 and enrolled in the present study. There were 205 cases where the patient succumbed to their injuries. In addition to the conventional diagnostic scheme for traumatic MODS, indexes of pancreatic β‑cell dysfunction [fasting blood‑glucose (FBG), homeostatic model assessment‑β and (blood insulin concentration 30 min following glucose loading‑fasting insulin concentration)/(blood glucose concentration 30 min following glucose loading‑FBG concentration)] were included to establish an improved diagnostic scheme for traumatic MODS. The novel scheme was subsequently used in clinical practice alongside the conventional scheme and its effect was evaluated. The novel scheme had a significantly higher positive number of MODS diagnoses for all trauma patients compared with the conventional scheme (12.48 vs. 8.87%; P<0.01). No significant difference was identified in the final percentage of positive of MODS diagnoses for trauma‑associated mortality patients between the novel (88.30%) and the conventional scheme (86.34%). The novel scheme had a significantly higher positive number of MODS diagnoses for trauma‑associated mortality patients 3 days prior to patients succumbing to MODS compared with the conventional scheme (80.98 vs. 64.39%; P<0.01). The consensus of the MODS diagnosis of all trauma patients between the novel scheme and the conventional scheme was 100%; however, out of the patients diagnosed as positive by novel scheme 71.03% were positive by the conventional scheme. The consensus between the final MODS diagnosis and the MODS diagnosis 3 days prior to patients succumbing to their injuries between the novel scheme and the conventional scheme was 100%; however, out of the patients diagnosed as positive by novel scheme 97.79 were positive by the conventional scheme of the 205 patients who succumbed to MODS and out of the patients diagnosed as positive for MODS by novel scheme 3 days prior to succumbing, 79.52% were positive by the conventional scheme. The results of the present study demonstrated that the novel diagnostic scheme using the relevant indexes of pancreatic β‑cell dysfunction for diagnosis of traumatic MODS, was able to diagnose MODS early without excessively extending the diagnostic scope. Its clinical application should be promoted.

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Section: Discussionmentioning

confidence: 99%

Clinical application of a novel diagnostic scheme including pancreatic β‑cell dysfunction for traumatic multiple organ dysfunction syndrome

et al. 2017

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“…Because in acute mountain sickness when many concurrent MODS pro-inflammation medium TNF alpha, IL-1, IL6, IL-8 significantly higher, and anti-inflammatory medium IL-4 is decreased obviously. Due to an imbalance between pro-inflammatory and anti-inflammatory mediators, neutrophil activation, oxygen free radicals and a large number of lysosomal enzyme release, ultimately leading to endothelial cells and parenchymal organs damage and multiple organ dysfunction [10] . The results of this study further supported this result and shows that hyperbaric oxygen therapy can reduce the activation of white blood cell, reduce the generation of pro-inflammatory cytokines, and thus avoid the activation of inflammatory pathways.…”

Section: Discussionmentioning

confidence: 99%

“…Diagnostic criteria: high altitude pulmonary edema and high altitude cerebral edema diagnosis is based on the Chinese Medical Association Branch of the Third National High Altitude Medicine's diagnostic criteria for diagnosis [3] . The diagnosis of severe acute mountain sickness complicated MODS in accordance with score diagnostic criteria of plateau-MODS for diagnosis [4] , see Table 2. Methods: The patients been diagnosed after admitted to hospital, all actively treating primary disease, strengthening support for treatment of metabolic.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic Efficacy of Hyperbaric Oxygen on the Severe Acute Mountain Sickness Complicated with MODS

Zhou

Zhang

Ciwang

et al. 2011

AMM

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Objective: To observe the treatment effects of hyperbaric oxygen on severe acute mountain sickness (ASHS) integrated with multiple organ dysfunction syndromes (MODS). Methods: 2006-2010 admitted to two hospitals in the Tibetan Plateau, 66 cases of patients who got the severe acute mountain sickness complicated by MODS were divided into two groups, 28 cases in the conventional therapy group, 38 cases in hyperbaric oxygen treatment therapy group, oxygen therapy, the conventional therapy concluded oxygen therapy, the treatment of primary disease and enhance the support for treatment of metabolic; hyperbaric oxygen group (was) on the basis of conventional therapy and hyperbaric oxygen therapy was used, the clinical effect of those two groups were compared with; with measured the before and after treatment blood levels of cytokines, to investigate the therapeutic mechanism of hyperbaric oxygen therapy. Results: The efficacy of hyperbaric oxygen treatment group and the treatment time are better than the conventional treatment group, hyperbaric oxygen treatment significantly reduced TNF, IL-6, IL-8 levels, and there is a significant difference between before and after treatment. Conclusion: the method of Hyperbaric oxygen for acute high altitude mountain disease complicated with MODS is reliable and had notable curative effect.

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“…It is useful as an indicator of the immune status and for the clinical diagnosis of infectious conditions. Studies have also shown an independent correlation between WBC counts and the incidence of organ injury [16][17][18]. Further studies have demonstrated that the degree of WBC infiltration in the kidneys is associated with the prognosis of AKI [19][20][21].…”

Section: Introductionmentioning

confidence: 95%

Association of WBC Levels With All-Cause Mortality in ICU Patients Receiving CRRT: A Retrospective Cohort Study

Huang,

Zhou

et al. 2023

Preprint

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Background Acute kidney injury (AKI) is a common comorbidity in the intensive care unit (ICU), with higher mortality rate among those who receive continuous renal replacement therapy (CRRT). This study aimed to investigate the association of white blood cell (WBC) levels with all-cause mortality in AKI patients undergoing CRRT. Method We conducted a post hoc analysis of ICU patient data from multiple centers in Korea. First, the levels of WBCs were classified into four groups based on quartiles. Second, the relationship between different WBC levels and mortality was investigated with the Kaplan-Meier (K-M) survival curves, Cox proportional hazards model, and generalized additivity model (GAM). Finally, we used multiple imputation to avoid bias caused by non-randomized missing data. The endpoints were short-term (28 days) and long-term (90 days) mortality. Result In our analysis, a total of 1,100 ICU patients were included. Among them, 670 (60.90%) and 781 (71.00%) died within 28 and 90 days, respectively. K-M survival curves showed that patients with the lowest WBC levels had the highest risk of mortality for both outcomes. Adjusted multivariate Cox regression analysis confirmed that compared with the reference level (quartile 2), low WBC levels increased the risk of both 28-day mortality (quartile 1, HR = 1.43, 95% CI: 1.13–1.83, P = 0.004) and 90-day mortality (quartile 1: HR = 1.32; 95% CI: 1.05-1.66, P = 0.016). GAM analysis showed a non-linear, U-shaped relationship between pre-CRRT WBC levels and all-cause mortality (non-linear P < 0.05). Conclusion The baseline WBC level is an independent predictor of prognosis for ICU patients receiving CRRT. Patients in the lowest WBC quartile had the highest risk of all-cause mortality. These results provide further evidence that early observation and intervention may have a prognostic value for these high-risk patients.

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Severe Acute Mountain Sickness Complicated by Multiple Organ Dysfunction Syndrome

Cited by 4 publications

References 28 publications

Clinical application of a novel diagnostic scheme including pancreatic β‑cell dysfunction for traumatic multiple organ dysfunction syndrome

Clinical application of a novel diagnostic scheme including pancreatic β‑cell dysfunction for traumatic multiple organ dysfunction syndrome

Therapeutic Efficacy of Hyperbaric Oxygen on the Severe Acute Mountain Sickness Complicated with MODS

Association of WBC Levels With All-Cause Mortality in ICU Patients Receiving CRRT: A Retrospective Cohort Study

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