Several Receptors Mediate the Antisecretory Effect of Peptide YY, Neuropeptide Y, and Pancreatic Polypeptide on VIP-Induced Fluid Secretion in the Rat Jejunum In Vivo

Souli, Abdelaziz; Chariot, J; Voisin, Thierry; Presset, Olivier; Tsocas, Annick; Balasubramaniam, Ambikaipakan; Laburthe, Marc; Rozé, C

doi:10.1016/s0196-9781(97)00069-7

Cited by 39 publications

(17 citation statements)

References 42 publications

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“…Caco-2 cells (passages [35][36][37][38][39][40][41][42][43][44][45] were cultured in DMEM supplemented with 20% FBS and 1% nonessential amino acids. Cells were kept at 37°C in 5% CO 2 and 90% humidity.…”

Section: Methodsmentioning

confidence: 99%

PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine

Buyse¹,

Berlioz²,

Guilmeau³

et al. 2001

J. Clin. Invest.

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Section: Methodsmentioning

confidence: 99%

PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine

Buyse¹,

Berlioz²,

Guilmeau³

et al. 2001

J. Clin. Invest.

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“…Also, deletion of either the Y2 or the Y4 receptor in the mouse was shown to increase the dark‐phase water intake ( Wultsch et al , 2006 ), indicating a decrease in water absorption due to the receptor knockouts. It should be noted that the antisecretory effects of PYY could involve the Y4 and Y1 receptors in addition to the Y2 receptor ( Souli et al , 1997 ).…”

Section: The Y2 Receptor In Behavior and Diseasementioning

confidence: 99%

Neuropeptide Y Y2 receptor in health and disease

Parker

Balasubramaniam

2008

British J Pharmacology

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We briefly survey the current knowledge and concepts regarding structure and function of the neuropeptide Y Y2 receptor and its agonists, especially as related to pharmacology of the receptor and its roles in pathological processes. Specific structural features are considered that could be responsible for the known compartmentalization and participation of the receptor in cell and tissue organization. This is further discussed in relation to changes of levels of the Y2 receptor in pathological conditions (especially in epilepsy and drug abuse), to endocytosis and recycling, and to participation in wound healing, retinopathy and angiogenesis. Properties of the receptor and of Y2 agonists are considered and reviewed in connection to the negative regulation of transmitter release, feeding, mood and social behavior. The possible involvement of the Y2 receptor in diabetes, carcinogenesis and bone formation is also reviewed.

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“…In the intestine, a PYY-preferring receptor mediates a potent inhibition of fluid and electrolyte secretion (86). The receptor is localized to the crypt cells where intestinal chloride secretion is believed to take place (87).…”

Section: Distribution and Physiological Effects Of The Pp-fold Peptidesmentioning

confidence: 99%

Multiple Receptors for the Pancreatic Polypeptide (PP-Fold) Family: Physiological Implications

Gehlert

1998

Experimental Biology and Medicine

169

116

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The pancreatic polypeptide (PP-fold) family of peptides consists of the endocrine peptides, pancreatic polypeptide (PP) and peptide YY (PYY), and the neuroneally derived peptide, neuropeptide Y (NPY). All three peptides are found in the circulation, with PP found primarily in the pancreas and PYY found principally in the gut. NPY is released into the circulation from neuroneal stores in response to stress. These peptides have broad peripheral actions on a number of organs. Not surprisingly, PYY and PP are believed to play an important role in the function of the gastrointestinal tract while NPY is a potent vasconstrictor and may have effects on the gut through the enteric nervous system. In the brain, NPY has been implicated in anxiety and depression, feeding and obesity, memory retention, neuroneal excitability, endocrine function, and metabolism. Recent advances in the molecular biology of the receptors for these peptides have resulted in the identification of at least six receptor subtypes with varying peptide pharmacology. Compared to other G-protein coupled receptor families, the PP-fold peptide receptors exhibit a relatively low level of sequence identity. Further advances in the development of selective agonists and antagonists for individual receptor subtypes will be needed to understand further their role in physiological function.

show abstract

Several Receptors Mediate the Antisecretory Effect of Peptide YY, Neuropeptide Y, and Pancreatic Polypeptide on VIP-Induced Fluid Secretion in the Rat Jejunum In Vivo

Cited by 39 publications

References 42 publications

PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine

PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine

Neuropeptide Y Y2 receptor in health and disease

Multiple Receptors for the Pancreatic Polypeptide (PP-Fold) Family: Physiological Implications

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