Seven Possible Mechanisms For Escherichia coli Diarrhea

Schlager, Theresa A.; Guerrant, Richard L.

doi:10.1016/s0891-5520(20)30214-2

Cited by 20 publications

(1 citation statement)

References 107 publications

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“…there are at least six or seven different ways in which E. coli can cause diarrhea (28). Represented among the E. coli diarrheas is a range of types of infectious diarrheas that include those caused by cholera-like and other enterotoxins (enterotoxigenic E. coli), inflammatory colitis caused by invasive organisms (enteroinvasive E. coli), diarrheas caused by effacing, enteroadherent organisms (enteropathogenic or enteroadherence factor-positive E. coli), and hemorrhagic diarrhea caused by enterohemorrhagic E. coli that produce Shiga-like toxin(s).…”

Section: Resultsmentioning

confidence: 99%

Net fluid secretion and impaired villous function induced by colonization of the small intestine by nontoxigenic colonizing Escherichia coli

1990

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The role of colonizing bacteria in the small bowel in causing diarrhea remains unclear. We examined whether colonizing, nontoxigenic Escherichia coli could alter small bowel function by determining net water and electrolyte fluxes and sucrase activity in colonized and noncolonized ileal segments by using the reversible-ileal-tie adult rabbit model. Colonization of the ileum with nontoxigenic E. coli for greater than or equal to 72 h at greater than or equal to 10(4)/cm2 was associated with significant functional derangements, as follows: (i) overt liquid diarrhea in 50% of animals colonized at greater than 10(4)/cm2; (ii) reversal of normal net ileal absorption to net secretion of water, sodium, and chloride; and (iii) significant decrease in mucosal sucrase activity. We conclude that small bowel colonization by colonizing, nontoxigenic E. coli impairs water and electrolyte absorption and sucrase activity in the absence of recognized enterotoxin, cytotoxin, invasion, or effacement traits.

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Section: Resultsmentioning

confidence: 99%