Seven‐day storage of single‐donor platelets: recovery and survival in an autologous transfusion study

Dumont, Larry J.; AuBuchon, James P.; Whitley, Pamela; Herschel, Louise; Johnson, Adrienne; McNeil, Deanna; Sawyer, Sherrie; Roger, J

doi:10.1046/j.1537-2995.2002.00147.x

Cited by 133 publications

(170 citation statements)

References 22 publications

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“…Several studies have showed that high levels of platelet activation may be related to a low survival potential for transfused platelets (3,4,19,20). However, Cardigan et al (21) reported that the reactivity of platelets to stimuli such as physiological agonists, rather than the glycoprotein expression without agonists, might be a better predictor of in vivo platelet transfusion efficacy.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of delta value of platelet parameters on ADVIA 120 for the functional reactivity of stored platelets

Park

Lim

Cho³

2010

Clinical Laboratory Analysis

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An agonist-induced expression of CD62P by flow cytometry analysis for evaluating platelet functional reactivity has some disadvantages. We investigated the usefulness of platelet parameters by ADVIA 120 to predict an agonist-induced expression of CD62P in stored platelets. The CD62P expression by flow cytometry and the platelet parameters by ADVIA 120 were studied in samples from 27 platelet pheresis products. Delta (D) values were calculated as the degree of change of the platelet parameters studied with or without adenosine 5 0 -diphosphate sodium (ADP) stimulation. The CD62P expression of the ADP-activated platelets were correlated with the Dplatelet count (r 5 0.517) in the short-term storage group (within 10 hr from preparation), with the platelet component distribution width (PCDW) without ADP (r 5 À0.744) and the DPCDW (r 5 À0.755) in the long-term storage group (after 10 hr from preparation). Therefore, the delta values of platelet parameters on ADVIA 120 analysis in platelets between with and without ADP stimulation could be useful as a simple predictor for the functional reactivity of stored platelets.

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Section: Discussionmentioning

confidence: 99%

Usefulness of delta value of platelet parameters on ADVIA 120 for the functional reactivity of stored platelets

Park

Lim

Cho³

2010

Clinical Laboratory Analysis

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“…Within the United States, premarket multicenter studies (or possibly postmarket studies) are currently under discussion to provide data that may allow the extension of storage to 7 days. It would be expected that the cost of culturing would be mitigated by the savings obtained by the extension of platelet storage time (20). For example, in Denmark, when bacterial culture was implemented in 1997, it was anticipated to be cost neutral if the outdating could be reduced from 18 to 8% by extending the storage time to 7 days (24).…”

Section: The Prospect Of Seven-day Storage With Detectionmentioning

confidence: 99%

Bacterial Contamination of Blood Components

2005

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Blood for transfusion is a potential source of infection by a variety of known and unknown transmissible agents. Over the last 20 years, astounding reductions in the risk of viral infection via allogeneic blood have been achieved. As a result of this success, bacterial contamination of blood products has emerged as the greatest residual source of transfusion-transmitted disease. This paper summarizes the current status of detection, prevention, and elimination of bacteria in blood products for transfusion

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“…Day 5 platelets were found to have a mean recovery of 63% and a mean survival of 160.8 hours, compared with day 7 platelets, which had a recovery and survival of 53.9% and 133.6 hours, respectively. 30 Numerous morphologic, biochemical and functional derangements occur during platelet storage. Platelets continue to be metabolically active at room temperature.…”

Section: Rapid Tests For Bacteriamentioning

confidence: 99%

Platelets: Testing, Dosing and the Storage Lesion—Recent Advances

Kaufman¹

2006

Hematology

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The demand for platelet transfusions continues to grow. Several complementary approaches that may help meet this demand in the future are reviewed. First, platelet bacterial testing is beginning to allow the extension of platelet storage beyond 5 days. Studies are also underway aimed at better preserving viability and function during ex vivo platelet storage: additive solutions and other approaches are being developed to try to negate the "platelet storage lesion." Finally, new approaches to dosing platelets may help extend the limited supply.

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Seven‐day storage of single‐donor platelets: recovery and survival in an autologous transfusion study

Cited by 133 publications

References 22 publications

Usefulness of delta value of platelet parameters on ADVIA 120 for the functional reactivity of stored platelets

Usefulness of delta value of platelet parameters on ADVIA 120 for the functional reactivity of stored platelets

Bacterial Contamination of Blood Components

Platelets: Testing, Dosing and the Storage Lesion—Recent Advances

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