Setup errors in radiation therapy for thoracic tumor patients of different body mass index

Zhao, Jing; Zhang, Mingyun; Zhai, Fushan; Wang, Haiyan; Li, Xingde

doi:10.1002/acm2.12270

Cited by 11 publications

(10 citation statements)

References 11 publications

(6 reference statements)

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“…The space available for the patient to move is larger for VC device, and it is possible that the patient slightly adjusted the position when the technician left. The effect of BMI on interfraction setup error has been demonstrated in several previous studies (15,27). These findings are consistent with findings of the current study.…”

Section: Discussionsupporting

confidence: 93%

Influence of Clinical and Tumor Factors on Interfraction Setup Errors With Rotation Correction for Vacuum Cushion in Lung Stereotactic Body Radiation Therapy

et al. 2021

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PurposeTo explore the influence of clinical and tumor factors over interfraction setup errors with rotation correction for non-small cell lung cancer (NSCLC) stereotactic body radiation therapy (SBRT) patients immobilized in vacuum cushion (VC) to better understand whether patient re-setup could further be optimized with these parameters.Materials and MethodsThis retrospective study was conducted on 142 NSCLC patients treated with SBRT between November 2017 to July 2019 in the local institute. Translation and rotation setup errors were analyzed in 732 cone-beam computed tomography (CBCT) scans before treatment. Differences between groups were analyzed using independent sample t-test. Logistic regression test was used to analyze possible correlations between patient re-setup and clinical and tumor factors.ResultsMean setup errors were the largest in anterior–posterior (AP) direction (3.2 ± 2.4 mm) compared with superior–inferior (SI) (2.8 ± 2.1 mm) and left–right (LR) (2.5 ± 2.0 mm) directions. The mean values were similar in pitch, roll, and rtn directions. Of the fractions, 83.7%, 90.3%, and 86.6% satisfied setup error tolerance limits in AP, SI, and LR directions, whereas 95% had rotation setup errors of <2° in the pitch, roll, or rtn directions. Setup errors were significantly different in the LR direction when age, body mass index (BMI), and “right vs. left” location parameters were divided into groups. Both univariate and multivariable model analyses showed that age (p = 0.006) and BMI (p = 0.002) were associated with patient re-setup.ConclusionsAge and BMI, as clinical factors, significantly influenced patient re-setup in the current study, whereas all other clinical and tumor factors were not correlated with patient re-setup. The current study recommends that more attention be paid to setup for elderly patients and patients with larger BMI when immobilized using VC, especially in the left–right direction.

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Section: Discussionsupporting

confidence: 93%

Influence of Clinical and Tumor Factors on Interfraction Setup Errors With Rotation Correction for Vacuum Cushion in Lung Stereotactic Body Radiation Therapy

et al. 2021

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“…Previous reports have suggested that setup error increases with BMI. 14 , 15 Our results did not support these findings; however, another limitation of our study is our small sample size. Seven out of 10 patients in our cohort had a BMI ≤23, thus our cohort may have not been powered to identify correlations between BMI and setup error.…”

Section: Discussioncontrasting

confidence: 72%

“…Previous reports have suggested that setup error increases with BMI 14,15 . Our results did not support these findings, however another limitation of our study is our small sample size.…”

Section: Discussionmentioning

confidence: 88%

Setup Accuracy in Craniospinal Irradiation: Implications for Planning Treatment Volume Margins

Novák

Shinde

et al. 2021

Advances in Radiation Oncology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Stepwise forward selection was used to build the models with significantly associated risk factors. Investigated factors included gender, age, race, Karnofsky index, body mass index (BMI, potentially worse outcome with larger BMI due to higher positioning uncertainty [25]), COPD, smoking history and pack years, medications (metformin, ACE-inhibitor, statins), tumor location (upper and middle lobes versus lower lobes), histology (adenocarcinoma versus squamous cell versus NSCLC without further differentiation), SUV max on pretreatment PET scan, treatment technique, BED 10 of the prescription dose, maximum BED 10 of PTV, and PTV volume (Table 1). All analyses used the statistical software SAS (Analytical Software and Solutions, https://www.sas.com) v9.4 and R (The R Project for Statistical Computing, https://r-project.org) v3.3.…”

Section: Statisticsmentioning

confidence: 99%

Effects of the recurrence pattern on patient survival following SABR for stage I lung cancer

et al. 2020

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Background: Information on the effect of the recurrence pattern on survival for stage I lung cancer following stereotactic ablative radiotherapy (SABR) is limited. Materials and Methods: The recurrence pattern was analyzed for 100 consecutive stage I non-smallcell lung cancer patients treated with SABR using predominantly 12 Gy Â 4. Recurrences were classified as local, regional lymph nodes and distant. Distant recurrences included recurrences in the lung and outside the chest. Single lung recurrences were named solitary, if no other location was involved. Kaplan-Meier survival estimates were calculated for different locations of recurrence. Clinical and dosimetrical factors affecting survival were also analyzed. Results: Median follow-up was 32 months (3-123), median age 70 years (49-95). In total, 31 patients had recurrences after a median 21 months (4-60): 5 local; 10 regional; 8 distant outside the chest; 25 non-local lung recurrences, of which 15 were single -10 of which solitaryand 10 multiple lung nodules. Patients with a solitary lung recurrence had longer survival compared to local or distant recurrences (p ¼ .04 each), and compared to multiple lung nodules (p ¼ .09). 3-year local recurrence-free survival was 92%, disease-free survival 69% and overall survival 59%. On multivariate analysis, diseasefree survival was associated with statin use (p ¼ .038) and tumor location (p ¼ .035). Smoking history predicted overall survival (p < .0006). Conclusions: A total of 81% of recurrences involved the lungs. Patients with solitary lung recurrences/ second primary lung cancers had the longest overall survival suggesting definitive treatment should be considered. The effects of statin use need to be explored further.

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Setup errors in radiation therapy for thoracic tumor patients of different body mass index

Cited by 11 publications

References 11 publications

Influence of Clinical and Tumor Factors on Interfraction Setup Errors With Rotation Correction for Vacuum Cushion in Lung Stereotactic Body Radiation Therapy

Influence of Clinical and Tumor Factors on Interfraction Setup Errors With Rotation Correction for Vacuum Cushion in Lung Stereotactic Body Radiation Therapy

Setup Accuracy in Craniospinal Irradiation: Implications for Planning Treatment Volume Margins

Effects of the recurrence pattern on patient survival following SABR for stage I lung cancer

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