Settings The Role of Methylglyoxal Accumulation on Cognitive Function Impairment of Chronic Hemodialysis Patients: an Observational Study

Abstract

Background: Cognitive function decline is prevalent on routine hemodialysis patients. Many factors contribute to the increased risk of cognitive function impairment, one of them is the accumulation of uremic toxins. Methylglyoxal (MG) has been identified as one of the uremic toxins found in dialysis patients by the European Uremic Toxin Group. It has also been found much higher on CKD patients; over five times higher in non-dialysis CKD and 18-40 times higher in CKD patients on dialysis, and cause impaired cognitive function in rats with diabetes. Aim: To find the correlation between blood MG levels and cognitive function of patients who underwent routine hemodialysis. Methods: This study is an observational cross-sectional study done in Hemodialysis Unit of Dr.