Set of Highly Stable Amine- and Carboxylate-Terminated Dendronized Au Nanoparticles with Dense Coating and Nontoxic Mixed-Dendronized Form

Abstract

The synthesis of a novel poly(propyleneimine) (PPI) dendron in gram scale as well as its use in the formation of a highly stable, dendronized gold nanoparticle (AuNP)-based drug delivery platform is described herein. The AuNP-based platform is composed of three complementary parts: (i) a 15 nm AuNP core, (ii) a heterofunctional thioctic acid-terminated tetraethylene glycol spacer, and (iii) a third-generation PPI dendron with a unique protonation profile and diverse end-group functionalization that allows for further derivatization. The prepared dendronized AuNPs are able to withstand several rounds of lyophilization cycles with no sign of aggregation, are stable in phosphate-buffered saline and Hanks' buffer as well as in serum, and are resistant to degradation *

Mild Whole-Body Hyperthermia-Induced Interstitial Fluid Pressure Reduction and Enhanced Nanoparticle Delivery to PC3 Tumors: In Vivo Studies and Micro-Computed Tomography Analyses

“…The AuNP-Citrate was then coated with a polypropyleneimine (PPI) dendron (TA-TEG-G3CO2H) previously developed in our labs [23]. For this, 250 mg (20 times molar excess of AuNP thiol coverage) of the TA-TEG-G3CO2H dendron dissolved in pH 8 water was added to 1 liter of AuNP-citrate solution and stirred for 1 day at room temperature.…”

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

“…Furthermore, in contrast to common surface coating ligands (oleylamine and dodecanethiol), dendritic ligands contributed to a much more significant increase in chemical and colloidal stability of AuNPs which was confirmed by cyanide‐induced decay and the shelf life of AuNPs (Elbert, Lee, Wu, & Murray, 2018). Moreover, in a recent study, dendritic G3 PPI coated with different terminal groups onto AuNPs endowed 15 nm AuNPs with a high density of surface coating and functional groups (1,450 dendrons/NPs, 11,600 dendritic branches/NPs), which would be in favor of a high payload of conjugable functional agents (Saha Ray et al, 2019). In the above reports, direct conjugation between the inorganic core and the dendritic coating was established via a spacer at the focal points of dendritic ligands.…”

A copper(ii) metal–organic framework with 2,2-dimethylglutarate and imidazole ligands: synthesis, characterization and catalytic performance for cycloaddition of CO2 to epoxides

“…In this regard, the effective carboxylation reaction that transforms CO 2 with epoxides, propargylic alcohols, amines, and alkenes has attracted significant interest from both industrial and academic perspectives. 5,8,9 The resulting carboxylated products are a collection of adaptable compounds with a wide range of inorganic synthesis applications, some of which have potential bioactivity appropriate for medicinal use. 10 Scientists doing research in this field have created some heterogeneous catalysts for CO 2 chemical conversion, keeping in mind the problems of product purification and catalyst recycling in homogeneous catalytic processes.…”

“…In this regard, the effective carboxylation reaction that transforms CO 2 with epoxides, propargylic alcohols, amines, and alkenes has attracted significant interest from both industrial and academic perspectives. 5,8,9 The resulting carboxylated products are a collection of adaptable compounds with a wide range of inorganic synthesis applications, some of which have potential bioactivity appropriate for medicinal use. 10…”