Sessile serrated adenomas in the proximal colon are likely to be flat, large and occur in smokers

Rustagi, Tarun; Rangasamy, Priya; Myers, Matthew; Sanders, Melinda; Vaziri, Haleh; Wu, George Y.; Birk, John; Protiva, Petr; Anderson, Joseph C.

doi:10.3748/wjg.v19.i32.5271

Cited by 33 publications

(30 citation statements)

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“…A family history of colorectal cancer has been shown to be a predictor of proximal adenomas and PSPs ( 34,38,49 ). An alternative pathway such as the BRAF-serrated pathway might predispose patients with a family history of CRC to PSPs that is associated with an increased risk of adenoma and colorectal neoplasia ( 38 ). However, our study did not detect family history of colorectal cancer to be an independent potential risk factor in PSPs with synchronous advanced neoplasia.…”

Section: Discussionmentioning

confidence: 59%

“…A total of 68 English language abstracts that involved human subjects were retrieved, and 28 potentially relevant studies were reviewed ( 10,(11)(12)(13). Aft er exclusion of 15 studies that did not report the information of interest ( 12,21,(23)(24)(25)(28)(29)(30)32,33,(35)(36)(37)(38)(39) and 4 studies that had insuffi cient data for meta-analysis ( 13,22,31,41 ), our fi nal analysis included nine studies published between 2009 and 2014.…”

Section: Search Resultsmentioning

confidence: 99%

“…Another interesting observation was that the association between PSPs and synchronous advanced colorectal neoplasia was not aff ected by the presence of a family history of colorectal cancer (OR=3.18, 95% CI, 1.55-6.49 vs. OR=2.77, 95% CI, 1.71-4.46). A family history of colorectal cancer has been shown to be a predictor of proximal adenomas and PSPs ( 34,38,49 ). An alternative pathway such as the BRAF-serrated pathway might predispose patients with a family history of CRC to PSPs that is associated with an increased risk of adenoma and colorectal neoplasia ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

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Serrated Polyps and the Risk of Synchronous Colorectal Advanced Neoplasia: A Systematic Review and Meta-Analysis

Gao

Tsoi

Hirai

et al. 2015

American Journal of Gastroenterology

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Section: Discussionmentioning

confidence: 59%

Section: Search Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Serrated Polyps and the Risk of Synchronous Colorectal Advanced Neoplasia: A Systematic Review and Meta-Analysis

Gao

Tsoi

Hirai

et al. 2015

American Journal of Gastroenterology

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“…Среди TSA выявлена следующая закономерность [14]: в дистальных отделах толстой кишки преобладали полиповидные формы, хорошо различимые при эндоско-пическом исследовании, а в проксимальных отделах -так называемые неполиповидные формы, обнаружение которых требует особой квалификации врача-эндоскопи-ста и применения специальной техники во время эндо-скопического исследования. В другом исследовании по-добная закономерность отмечена и среди SSA/P [15]. Преобладание дистального расположения среди SSA/P, выявленное в нашем исследовании, может являться сви-детельством гиподиагностики SSA/P в связи со сложно-стью выявления проксимально расположенных «неполи-повидных» образований.…”

Section: Discussionunclassified

Serrated lesions of the large intestine: Prevalence analysis and clinical and morphologic characteristics

Kharlova¹,

Nv²,

Malkov³

et al. 2015

Arkh. patol.

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Цель исследования -ретроспективная оценка распространенности зубчатых образований, выявление особенностей рас-пределения зубчатых образований среди ранее диагностированных классических аденом и гиперпластических полипов. Материал и методы. Методом сплошной выборки из архивного материала отобраны биоптаты 440 полиповидных обра-зований толстой кишки, поступившие за 2012-2013 гг., которые подвергнуты повторному морфологическому исследо-ванию с участием трех экспертов. Морфологические критерии диагностики разных типов зубчатых образований при-няты на основании классификации предопухолевых поражений толстой кишки ВОЗ 2010 г. и рекомендаций экспертной группы (Am. J. Gastroenterology 2012 г.). Результаты. К группе зубчатых образований отнесено 13,7% тубулярных аденом, 12,5% тубуловорсинчатых аденом и 50% ворсинчатых аденом. В результате пересмотра было выделено 121 зубчатое образование, в том числе гиперпластических полипов 55 (45,5%), зубчатых аденом/полипов на широком основании (SSA/P) 24 (19,8%), среди них с дисплазией 6 (5%), традиционных зубчатых аденом (TSA) 20 (16,5%), среди них с диспла-зией 14 (11,6%), неклассифицируемых зубчатых полипов 22 (18,2%). Большинство гиперпластических полипов (89%) и SSA/P (71%) располагались дистальнее селезеночного изгиба толстой кишки, TSA распределены между проксимальными и дистальными частями толстой кишки равномерно. Доля зубчатых образований с дисплазией составила 16,5%, среди SSA/P -25%, среди TSA -70%. Зубчатые образования с дисплазией чаще расположены проксимально и имели более крупный размер, чем образования без дисплазии. Заключение. Зубчатые образования толстой кишки являются более рас-пространенными образованиями толстой кишки, чем считалось ранее. В результате пересмотра выявлено, что зубчатые образования встречаются как среди ранее существовавшей группы гиперпластических полипов, так и среди всех групп классических аденом, что свидетельствует о необходимости повсеместного внедрения современной классификации в ежедневную диагностическую работу. Ключевые слова: зубчатые образования, гиперпластический полип, зубчатая аденома/полип на широком основании, традиционная зубчатая аденома.Objective: to retrospectively estimate the prevalence of serrated lesions of the large intestine and to reveal the features of distribution of serrated lesions in the previously diagnosed classical adenomas and hyperplastic polyps. Material and methods. A continuous sampling method was used to take biopsy specimens from the archive material of 440 polypoid lesions of the large intestine, which had entered in 2012-2013, and which were be morphologically reexamined by three experts. The morphological criteria for diagnosing different types of serrated lesions were taken according to the 2010 WHO classification of premalignant lesions of the large intestine and to the recommendations from an expert panel (Am J of Gastroenterology 2012). Results. A group of serrated lesions included tubular (13.7%), tubulovillous adenomas (12.5%), and villous (50%) adenomas. The reexamination revealed 121 serrate...

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“…We divided the invasion of the submucosa into three levels: sm1, sm2 and sm3. The splenic flexure is considered proximal by some authors 11 and distal by others 12 . In this work, we considered the splenic flexure, descending and sigmoid colon as distal (G1), and the cecum, ascending and transverse colon as proximal (G2).…”

Section: Methodsmentioning

confidence: 99%

Comparative analysis of endoscopic and histopathological features of superficial elevated lesions resected by endoscopic mucosal resection in the distal and proximal colon

Parada

Ribas

Venco³

et al. 2016

Rev. Col. Bras. Cir.

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Objective: to compare endoscopic and histopathologic features of superficial, elevated lesions with one or more centimeters in diameter, diagnosed by videocolonoscopy on the distal and proximal colon, and subjected to mucosal resection. Methods: we conducted a retrospective, cross-sectional, observational study involving 8,075 videocolonoscopies. From this total, we evaluated 166 mucosectomies in 145 patients with superficial, elevated lesions with a diameter equal to or greater than 1cm. Results: the lesion prevalence was lower in G1 than in G2 (34.9% vs. 65%). The mean age, gender distribution and size (1.9cm in G1 versus 2.0cm in G2, p=0.921) were similar. There was no difference of mucosal surfaces in relation to the location (p=0.575). Considering Intraepithelial neoplasias, both the low grade, high grade (including carcinomas) and hyperplasic ones showedd no difference (p=0.527), nor did the neoplastic lesions when divided into serrated and non-serrated (p=0.124). Excluding 13 hyperplastic lesions and two carcinomas, 124 (82.1%) were non-serrated and 27 (17.9%), serrated. Conclusion: were found no significant differences between endoscopic and histopathological aspects of superficial, elevated lesions of 1cm or more in diameter in distal colon compared with the proximal, when resected by mucosectomy. Although not significant, there was a tendency of association between the location of the lesion and the presence of serrated features.

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Sessile serrated adenomas in the proximal colon are likely to be flat, large and occur in smokers

Abstract: Proximal SSAs which accounted for two-fifths of all SSAs were more likely to present as flat lesions, larger SSAs, and were more likely to occur in smokers and in patients with family history of colorectal cancer. Our data has implications for colorectal cancer screening.

Cited by 33 publications

References 0 publications

Serrated Polyps and the Risk of Synchronous Colorectal Advanced Neoplasia: A Systematic Review and Meta-Analysis

Serrated Polyps and the Risk of Synchronous Colorectal Advanced Neoplasia: A Systematic Review and Meta-Analysis

Serrated lesions of the large intestine: Prevalence analysis and clinical and morphologic characteristics

Comparative analysis of endoscopic and histopathological features of superficial elevated lesions resected by endoscopic mucosal resection in the distal and proximal colon

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