Sessile Serrated Adenoma of the Appendix in an Asymptomatic Patient

Figueroa-Rivera, Ivonne; Santiago-Rivera, Loscar; Magno, Priscilla

doi:10.1016/j.cgh.2017.07.014

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Cytological atypia may be mild and may include dystrophic goblet cells. The lumen may contain abundant mucin [10,34,40,41]. The most common mutations occur in the KRAS (Kirsten Rat Sarcoma Viral Proto-Oncogene) gene, followed by those in the BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase) gene and, very rarely, in the RNF43 (Ring Finger Protein 43) gene [35,37,42].…”

Section: Hyperplastic Polyps Sessile Serrated Lesions Without Dysplas...mentioning

confidence: 99%

The Vermiform Appendix and Its Pathologies

Constantin,

Petrescu,

Mătanie

et al. 2023

Cancers

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The vermiform appendix is a muscular cylindrical structure originating near the junction of the cecum and ileum, averaging 9 cm (5–35 cm) in size. As the most mobile viscera, it can adopt several positions, the most common being the retrocecal position. Perceived as an atavistic organ lacking physiological relevance, the vermiform appendix appears to be involved in immune function, serving in the maturation of B lymphocytes and the production of immunoglobulin A, in endocrine function, excreting amines and hormones in the 2–3 mL of mucus secreted daily, and in digestive function, by storing beneficial bacteria from where they can recolonize the colon. With a lumen of about 6 mm, the vermiform appendix has a reduced storage capacity, so any blockage of the appendix with fecoliths (fecaliths), seeds derailed from the colon, or enlarged lymph nodes prevents drainage and intraluminal accumulation of secreted mucus. Unable to relax, the appendix wall severely limits its intraluminal volume, so mucus accumulation leads to inflammation of the appendix, known generically as appendicitis. In addition, the vermiform appendix may be the site of the development of neoplastic processes, which may or may not involve mucus production, some of which can significantly affect the standard of living and ultimately lead to death. In general, mucinous tumors may have a better prognosis than non-mucinous tumors. This review takes a comprehensive path, starting by describing the anatomy and embryology of the vermiform appendix and further detailing its inflammatory pathologies, pathologies related to congenital anomalies, and appendix tumors, thus creating an up-to-date framework for better understanding, diagnosis, and treatment of these health problems.

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Section: Hyperplastic Polyps Sessile Serrated Lesions Without Dysplas...mentioning

confidence: 99%

The Vermiform Appendix and Its Pathologies

Constantin,

Petrescu,

Mătanie

et al. 2023

Cancers

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“…В 2017 году Figueroa-Rivera I.M. et al наблюдали в своей практике зубчатую аденому, которая во время колоноскопии выглядела как субмукозное образование устья аппендикса с центральным вдавлением "vulcano sign", а микроскопически распространилась на всю длину червеобразного отростка [12]. В 2018 году Adhya A. K. и Misra P. обнаружили сидячую зубчатую аденому в аппендиксе при рутинной обработке материала, поступившего от пациента с острым аппендицитом [13], Biswas S. и соавторы описали сидячую зубчатую аденому аппендикса в сочетании с перфоративной лимфомой слепой кишки у мужчины 92 лет [14], Sato K. с коллегами опубликовали материалы 69-летнего пациента с острым перфоративным аппендицитом и сидячей зубчатой аденомой червеобразного отростка, осложнившиеся перитонитом и множественными пиогенными абсцессами печени [15].…”

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Sessile serrated adenoma of the appendix: literature review and clinical cases

Михалева

Vandysheva

Kozlov

et al. 2020

jour

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The article contains a literature review of clinical cases describing sessile serrated adenomas in the appendix from 1998 to 2018. Currently, it is still diffi cult to assess the true incidence of this pathology due to the fact that in most cases serrated adenomas are accidental fi ndings diagnosed after removing an inflamed appendix, since often, at small sizes, they do not cause clinical symptoms, do not bother patients and are inaccessible for endoscopic examination (if located behind its orifi ce). In addition, we present 2 clinical cases of sessile serrated adenoma of the appendix in patients who were admitted to the City Clinical Hospital No. 31 of the Moscow City Health Department in 2018 due to acute appendicitis, with a clinical and morphological characteristic, including a molecular genetics study.

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“…Medical history included hysterectomy with adnexectomy and appendectomy. Apart from cecal angiodysplasias, a tenacious mucus lake was detected at the appendix base (“cecal mucus sign”) [1, 2] (Fig. 1a).…”

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confidence: 99%