Sesquiterpenoids from the rhizomes of Homalomena pendula and their anti-inflammatory activities

Abstract

Sixteen sesquiterpenoids including two new ones, homalolides AB (1-2), were firstly isolated from the methanolic extract of the rhizomes of Homalomena pendula collected in Vietnam. The structures and relative stereochemistry of new compounds were elucidated by 1D-/2D-NMR, IR, UV and HRESIMS analyses. The GCMS experiment demonstrated that homalolide A ( 1) is an artifact due to the methylation during methanolic extraction process.All isolates (1-16) were tested for their inhibitory activities against lipopolysaccharideinduced nitric oxide production in the RAW 264.7 macrophage cell line. Compounds 1, 3, 6-8, 10-12 displayed moderate inhibitory effect on NO production with IC 50 values ranging from 35.41 to 64.06 μM.

Volatile Constituents and Anti-Osteoporotic Activity of the n-Hexane Extract From Homalomena gigantea Rhizome

“…However, the presence of homalolide A may have been an artifact due to methylation during the methanolic extraction process. 24 α-Cadinol, 33 homalomenol C, 34 homalomenol A, bullatantriol, and 1β,4β,7α-trihydroxyeudesmane, 35 spathulenol, 36 teucmosin, 37 oplopanone, 38 and 1α,4β,5α,6β,7βH,10β-4,10-epoxy-6-guainol 39 have also been isolated from other Homalomena species. Osteoblasts produce ALP in the bone and play an important role in bone growth and quality.…”

“…22,23 Earlier research demonstrated its anti-inflammatory properties. 24 In this work, we determined the chemical composition of the volatile oil by preparing an n -hexane extract of the plant, as well as its anti-osteoporotic characteristics associated with alkaline phosphatase (ALP) activity, collagen content, and mineralization. Our results show that H. gigantea stimulates osteoblast differentiation and proliferation, thus enhancing bone growth.…”

Volatile Components and Biological Activities of n-Hexane Extract From Rhizomes of Homalomena cochinchinensis

“…6,7 Investigating the composition and biological activities of H cochinchinensis rhizomes is important for clarifying the role of this plant in folk medicine. As part of an ongoing investigation of bioactive metabolites from plants of the Homalomena genus collected in Vietnam, [8][9][10] we report herein the composition of volatile components from H cochinchinensis rhizomes. We also investigated the extract's cytotoxic activity against SK-LU-1 (human lung adenocarcinoma), HepG2 (human hepatocellular carcinoma), and MCF7 (human breast cancer) cell lines; its inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells; and its capacity for acetylcholinesterase (AChE) inhibition.…”