In this study, we analyzed the volatile constituents of the n-hexane extract from the rhizomes of Homalomena cochinchinensis Engl. by gas chromatography-mass spectrometry (GC-MS). We also investigated the anti-inflammatory, acetylcholinesterase (AChE) inhibitory, and cytotoxic activities of this extract. GC-MS analysis revealed the presence of 25 compounds, of which linalool was the primary component (17.6%). The extract significantly inhibited lipopolysaccharide-induced production of nitric oxide in RAW264.7 cells (IC50 = 21.08 ± 1.80 µg/mL); displayed weak cytotoxic activity against SK-LU-1, HepG2, and MCF7 cancer cell lines (IC50 values ranged from 154.60 to 184.25 µg/mL); and exhibited a weak capacity for AChE inhibition (IC50 = 131.10 ± 9.76 µg/mL). This report is the first to examine the volatile components and biological activities of the n-hexane extract from rhizomes of Homalomena cochinchinensis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.