Sesquiterpenes from the roots of Lindera strychnifolia with inhibitory effects on nitric oxide production in RAW 264.7 cells

Liu, Qing; Jo, Yang Hee; Kim, Seon Beom; Jin, Qinghao; Hwang, Bang Yeon; Lee, Mi Kyeong

doi:10.1016/j.bmcl.2016.09.012

Cited by 13 publications

(11 citation statements)

References 27 publications

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“…9,10 Earlier chemical and pharmacological studies on this endemic species of L. akoensis suggested that its butanolides account for its anti-inammatory activities and antimycobacterial activities against Mycobacterium tuberculosis H37Rv. 5,11,12 Previous studies on the aerial part of L. akoensis resulted in isolation of 10 butanolides, ve lignans, and ve avonols.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory flavonol acylglycosides from the aerial part of Lindera akoensis Hayata

et al. 2017

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Five new flavonol acylglycosides, linderakosides A-E (1-5), together with 30 known compounds were isolated from the aerial part of Lindera akoensis Hayata. The structures were established using extensive spectroscopic analysis and comparison of NMR data with those of known compounds. The flavonol acylglycosides 1, 2, and 5 showed in vitro anti-inflammatory activity, which decreased LPS-stimulated nitrite production in RAW 264.7 cells. The structure activity relationships (SAR) of the flavonol acylglycoside compounds were also established to research for potential lead compounds as anti-inflammatory drugs.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory flavonol acylglycosides from the aerial part of Lindera akoensis Hayata

et al. 2017

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“…Inhibition of overstimulated inflammatory cytokines and NO is a potential therapeutic target for inflammatory disease. Linderolide O (compound 36 in Table 1 ), linderolide P (compound 37 in Table 1 ), NOR, and boldine (compound 1 in Table 2 ) inhibited lipopolysaccharide (LPS)-stimulated nitric oxide production in murine RAW 264.7 macrophage cells, with IC 50 values of 6.3 and 9.6 37.8, and 38.7 μM, respectively ( 20 , 37 ).…”

Section: Pharmacologymentioning

confidence: 99%

“…As shown in Table 1 and Figure 2, modern phytochemistry studies reveal that the sesquiterpenoids isolated from L. aggregata are mainly featured as monomer-, dimer-, and hybrid forms. The sesquiterpenoid monomers include eudesmane- , lindenane- , germacrane- (53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69), elemane-(70-73), guaiane- (74)(75)(76), cadinane- (77)(78), copane- (79), eremophilane- (80), and other types (81)(82)(83)(84) (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). So far, the sesquiterpenes of L. aggregata account for more than half ...…”

Section: Sesquiterpenoidsmentioning

confidence: 99%

A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (Sims) Kosterm

Zou²,

Zhang³

et al. 2023

Front. Nutr.

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Lindera aggregata (Sims) Kosterm. (L. aggregata), which belongs to the genus Lindera in the family Lauraceae, is widely distributed in Asia and the temperate, tropical regions of North America. Its roots and leaves have been used for thousands of years as traditional Chinese medicine and/or functional food. To further explore its underlying nutritional value, this review provided a comprehensive insight into chemical constituents and pharmacological effects on L. aggregata. The phytochemical investigation of different parts of L. aggregata led to the identification of up to 349 components belonging to sesquiterpenoids, alkaloids, flavonoids, essential oils, and other compounds. Among them, sesquiterpenoids, flavonoids, and alkaloids are assessed as representative active ingredients of L. aggregata. A wide variety of pharmacological effects of L. aggregata, such as anti-hyperlipidemic, anti-tumor, anti-inflammatory, analgesic, and anti-oxidant, have been proved in vitro and in vivo. In summary, this review aims to provide a scientific basis and reference for further research and utilization of L. aggregata and lay the foundation for developing functional foods with potential active ingredients for the prevention and management of related diseases.

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“…Compound 1 was isolated as a brownish powder. Its molecular formula was determined as C 16 and 20.2), one methoxy (at δ C 52.8), two methylenes (at δ C 17.6, 54.4), one exo-methylene (at δ C 108.6), three methines (at δ C 29.1, 24.4 and 67.2), one oxygenated methine (at δ C 65.9), and six quaternary carbons. In the 1 H NMR spectrum, two methyl signals at δ H 0.74 and 2.10 (each 3H), one methoxyl at δ H 3.72 (3H, s), one hydroxymethine at δ H 4.42 (1H, dd, J = 11.0, 0.9), and three methines at δ H 1.45 (1H, ddd, J = 8.0, 7.1, 3.6), 2.04 (1H, m) and 2.79 (1H, ddd, J = 11.0, 3.2.…”

Section: Structural Elucidation Of Compounds 1 Andmentioning

confidence: 99%

“…Recent studies also reported antioxidant, anti-diabetic, and anti-inflammatory effects of Lindera root. Sesquiterpenes are major constituents of this plant, and alkaloids and tannins are also isolated [ 14 , 15 , 16 , 17 ]. The crude extract of the root of L. strychnifolia enhanced the antioxidant response element (ARE) activity in an ongoing screening for natural products in HepG2-ARE luciferase assay.…”

Section: Introductionmentioning

confidence: 99%

Bioassay-Guided Isolation of Two Eudesmane Sesquiterpenes from Lindera strychnifolia Using Centrifugal Partition Chromatography

et al. 2021

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In this study, a centrifugal partition chromatography (CPC) separation was applied to identify antioxidant-responsive element (ARE) induction molecules from the crude extract of Lindera strychnifolia roots. CPC was operated with a two-phase solvent system composed of n-hexane-methanol-water (10:8.5:1.5, v/v/v) in dual mode (descending to ascending), which provided a high recovery rate (>95.5%) with high resolution. Then, ARE induction activity of obtained CPC fractions was examined in ARE-transfected HepG2 cells according to the weight ratios of the obtained fractions. The fraction exhibiting ARE-inducing activity was further purified by preparative HPLC that led to isolation of two eudesmane type sesquiterpenes as active compounds. The chemical structures were elucidated as linderolide U (1) and a new sesquiterpene named as linderolide V (2) by spectroscopic data. Further bioactivity test demonstrated that compounds 1 and 2 enhanced ARE activity by 22.4-fold and 7.6-fold, respectively, at 100 μM concentration while 5 μM of sulforaphane induced ARE activity 24.8-fold compared to the control.

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Sesquiterpenes from the roots of Lindera strychnifolia with inhibitory effects on nitric oxide production in RAW 264.7 cells

Cited by 13 publications

References 27 publications

Anti-inflammatory flavonol acylglycosides from the aerial part of Lindera akoensis Hayata

Anti-inflammatory flavonol acylglycosides from the aerial part of Lindera akoensis Hayata

A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (Sims) Kosterm

Bioassay-Guided Isolation of Two Eudesmane Sesquiterpenes from Lindera strychnifolia Using Centrifugal Partition Chromatography

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