Sesquiterpene Phenylpropanoid and Sesquiterpene Chromone Derivatives from Ferula pallida

Abstract

Four novel compounds-two sesquiterpene phenylpropanoid derivatives, pallidones G (1) and H (2), and two sesquiterpene chromone derivatives, pallidones I (3) and J (4)-have been isolated from the roots of Ferula pallida. Their structures were determined on the basis of NMR and HREIMS evidence.

Four new glucosides from the aerial parts of Mediasia macrophylla

“…We have been investigating the herbal medicines of Uzbekistan with the aim of searching for novel drug leads (Umbelliferae [1][2][3][4][5][6][7][8][9][10], Compositae [11][12][13][14], Guttiferae [15,16], Polygonaceae [17], Cupressaceae [18], Paeoniaceae [19]). The aerial parts of Mediasia macrophylla (Umbelliferae) have been used traditionally as a perfume; an appetite enhancer; a natural preservative; and for treatment of rheumatism, nephritis, eczema, herpes, and injury [20].…”

“…The isolation of C 10 -polyacetylene glucosides from the family Umbelliferae was the first example of this type of compound from this source. Further chemical examination of this plant has now resulted in the isolation of four new glucosides (1)(2)(3)(4), together with 30 known compounds. We now report on the isolation and structure elucidation of these compounds.…”

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“…In addition, people in Nepal eat it, in daily diets and also thought that Asafoetida has diuretic, sedative, and aphrodisiac properties. [8,9] It is also used in the treatment of various diseases such as intestinal parasites, flatulence, influenza, epilepsy, stomachache, asthma, and weak digestion. [3,5,7] The pharmacological studies include antioxidant, [10] cancino preventive, [11,12] antidiabetic, [13] antiviral, [7] hypotensive, [14] antifungal, [15][16][17] antispasmodic, [14] and molluscicidal [17,18] from this oleo-gum-resin.…”

Crystal and molecular structure of lancerodiol-p-hydroxybenzoate

“…[4] The widespread sesquiterpene compounds in this genus are characteristic dauicanes, humulanes, himachalanes, germacranes, eudesmanes, and guainanes. [5] Chemically, the resin of the species is characterized by the presence of sesquiterpenes,[5–8] sesquiterpene coumarines,[7–9] and monoterpenes. [9–12] Investigation of the CH 2 Cl 2 :MeOH (1:1) extract of the leaves of F. sinaica led to the isolation of lancerodiol– p –hydroxybenzoate 1 .…”