Sesquiterpene Lactones Revisited

Maries, Robin J.; Pazos-Sanou, L; Compadre, César M.; Pezzuto, John M.; Bloszyk, E.; Arnason, John T.

doi:10.1007/978-1-4899-1778-2_13

Cited by 18 publications

(39 citation statements)

References 48 publications

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“…Much attention has been paid to the antitumor properties associated with their cytotoxicity. Recently, serotonin release inhibition, related to antimigraine action of some lactones, has been extensively investigated (1). Besides, some sesquiterpene lactones of agrochemical importance (antifungal, phytotoxic) have been found (2).…”

Section: Introductionmentioning

confidence: 99%

“…Several sesquiterpene lactones are constituents of Helenium aromaticum (Compositae): helenalin, mexicanin I, linifolin A, geigerinin, and Telekia speciosa (Compositae): 6a-hydroxy-2,3-dihydroaromaticin, asperilin, telekin. Helenalin and its derivatives have received considerable attention in pharmacological research due to their potent antineoplastic and anti-inflammatory activity (1).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Several Sesquiterpene Lactones on Lipid Peroxidation and Glutathione Level

Jodynis‐Liebert

Murias²,

Bloszyk³

1999

Planta med

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Seven sesquiterpene lactones isolated from Helenium aromaticum: helenalin, mexicanin I, linifolin A, geigerinin, and from Telekia speciosa: 6 alpha-hydroxy-2,3-dihydroaromaticin, asperilin, telekin have been tested for their hydroxyl radical scavenging activity and effect on lipid peroxidation. All compounds were found to be potent hydroxyl radical scavengers but did not affect lipid peroxidation in vitro. In vivo they exerted pro-oxidative properties and caused glutathione level depletion and elevation in glutathione peroxidase activity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Several Sesquiterpene Lactones on Lipid Peroxidation and Glutathione Level

Jodynis‐Liebert

Murias²,

Bloszyk³

1999

Planta med

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“…When serotonin release inhibition and cytotoxicity were correlated in a former study, no correlation was observed. 6 Generation of a Counterpropagation Neural Network. The 54 SLs of the data set comprising compounds with IC 50 values between 1.78 and >624.2 µM were grouped into six activity classes as described in Experimental Section.…”

Section: Resultsmentioning

confidence: 99%

“…Because highdimensional values of a 3D structure representation shall be used as descriptors, CPGNN is a suitable option. 22 On the basis of the above-mentioned data set of 54 SLs, 6 MEP, molecular electrostatic potential; mmPol, mean molecular polarizability; TPSA, topological polar surface area; π, atom-π-electronegativity; σ, atom-σ-electronegativity; Rd, effective atom polarizability; qσ, atom-σ-charge the NF-κB activity of SLs 12 allows the specification of structural features necessary for either serotonin or NF-κB activity.…”

Section: Introductionmentioning

confidence: 99%

Neural Networks as Valuable Tools To Differentiate between Sesquiterpene Lactones’ Inhibitory Activity on Serotonin Release and on NF-κB

et al. 2008

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Sesquiterpene lactones are the active components of a variety of medicinal plants from the Asteraceae family. They possess biological activities such as the inhibition of NF-kappaB and the release inhibition of the vasoactive serotonin. On the basis of a data set of 54 SLs, we report the development of a quantitative model for the prediction of serotonin release inhibition. Comparing this model with a previous investigation of the target NF-kappaB, structural features necessary for specific compounds could be acquired. Atomic properties encoded by radial distribution function and molecular surface potentials encoded by autocorrelation were used as descriptors. Whereas some descriptors describe the structural requirements for both activities, other descriptors can be used to decide whether an SL is more active to NF-kappaB or to serotonin release. Again, counter propagation neural networks proved to be a valuable tool to establish structure-activity relationships that are necessary for the search for and optimization of lead structures.

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“…apresentarem uma grande variedade de atividades biológicas. [5][6][7][8][9][10][11][12][13] Algumas estratégias sintéticas para a construção do sistema de anéis característico dos tremulanos têm sido desenvolvidas. [14][15][16][17][18][19][20] Em 1995, Habeck e colaboradores 14 publicaram a primeira síntese conforme mostrado no esquema 1.…”

Section: Introdução 1 Introduçãounclassified

Estudos sintéticos de 5,6-seco-tremulanos

Rodrigues¹

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Sesquiterpene Lactones Revisited

Cited by 18 publications

References 48 publications

Effect of Several Sesquiterpene Lactones on Lipid Peroxidation and Glutathione Level

Effect of Several Sesquiterpene Lactones on Lipid Peroxidation and Glutathione Level

Neural Networks as Valuable Tools To Differentiate between Sesquiterpene Lactones’ Inhibitory Activity on Serotonin Release and on NF-κB

Estudos sintéticos de 5,6-seco-tremulanos

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