Effect of Several Sesquiterpene Lactones on Lipid Peroxidation and Glutathione Level

Jodynis‐Liebert, Jadwiga; Murias, Marek; Bloszyk, E.

doi:10.1055/s-1999-13994

Cited by 22 publications

(17 citation statements)

References 18 publications

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“…Upon ER stress, high amounts of Ca 2+ can be released into the cytosol, mediating further downstream effects such as apoptosis [50] or autophagy [51]. We could not observe increased calcium level in response to helenalin treatment, although helenalin has been reported to decrease cellular glutathion levels [52], which is frequently associated with an increase of resting intracellular calcium, leading to cytotoxicity [53]. Furthermore, helenalin does not alter the expression of BiP/GRP78 and CHOP/GADD153, two markers for ER-stress [54,55].…”

Section: Bcl-2-mediated Death Resistance This Might Open Up a Novel contrasting

confidence: 63%

Helenalin bypasses Bcl-2-mediated cell death resistance by inhibiting NF-κB and promoting reactive oxygen species generation

Hoffmann

Schwarzenberg

López-Antón

et al. 2011

Biochemical Pharmacology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractEvasion of cell death by overexpression of anti-apoptotic proteins, such as Bcl-2, is commonly observed in cancer cells leading to a lack of response to chemotherapy.Hence, there is a need to find new chemotherapeutic agents that are able to overcome chemoresistance mediated by Bcl-2 and to understand their mechanisms of action. Helenalin, a sesquiterpene lactone ( and free intracellular iron as mediators of helenalin-induced cell death whereas activation of JNK and abrogation of Akt activity did not contribute to helenalin-elicited cell death. Our results highlight the NF-κB inhibitor helenalin as a promising chemotherapeutic agent to overcome Bcl-2-induced cell death resistance.

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Section: Bcl-2-mediated Death Resistance This Might Open Up a Novel contrasting

confidence: 63%

Helenalin bypasses Bcl-2-mediated cell death resistance by inhibiting NF-κB and promoting reactive oxygen species generation

Hoffmann

Schwarzenberg

López-Antón

et al. 2011

Biochemical Pharmacology

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“…Although numerous assays are available to find out the antioxidant activity. Some reported methods include 1,1-diphenyl-2-picrylhydrazine (DPPH) radical scavenging assay, 1,1-diphenyl-2-picrylhydrazine (DPPH) radical scavenging activity [16], ferric reducing antioxidant power assay [17], oxygen radical absorbance capacity assay [18], total radical trapping antioxidant potential assay [19], LPO method [20], superoxide anion scavenging activity [21], 2,2_-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging method [22,23], hydroxyl radical scavenging activity [24,25], reducing power assay [26], thiobarbituric acid method [27], and Folin-Ciocalteu (FTC) method [28].…”

Section: Some Assay Methods Used To Estimate Antioxidant Content Presmentioning

confidence: 99%

Medicinal Plants as Potential Source of Antioxidant Agents: A Review

Ayoub

Mehta

2018

Asian J Pharm Clin Res

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All over the world, the recent scientific studies revealed the medicinal properties of plants, which have been examined, because of their effective pharmacological activities, economic viability, and their low toxicity. Reactive oxygen species (ROS) enhancement by endogenous and exogenous stimuli can modify redox circumstances of normal cells. To balance ROS-mediated cellular damage, endogenous antioxidants’ protection system subsists; however, when oxidation surpasses the control mechanisms, oxidative stress increases. Detrimental alterations induced in a variety of biomolecules such as proteins, lipids, and DNA which causes chronic escalation of oxidative stresses, which ultimately causes tissue damage and results in numerous diseases. Antioxidants reduce the effects of ROS and help us in the prevention of such diseases. Antioxidants can either be natural or synthetic. Natural antioxidants can be obtained through diet in the form of fruits, spices, vegetables, etc. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole also diminish oxidation, but they have been proved to be dangerous to humankind; therefore, investigation for non-toxic antioxidants has increased in the recent years.

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“…Telekin affected activity of some antioxidant and drug-metabolizing enzymes in rat liver and kidney [11,12]. In a recently published report on antiproliferative and direct cytotoxic activity of extracts from T. speciosa an interference of these preparations with cell proliferation in vitro has been proven [13].…”

Section: Introductionmentioning

confidence: 99%

“…Except for widely investigated alantolactone and isoalantolactone, other sesquiterpene lactones -telekin and 2,3-dihydroaromaticin have also shown marked antiproliferative activity against human cancer cell lines in vitro [7,8]. Moreover, 2,3-dihydroaromaticin is a potent inhibitor of lipopolisaccharide induced nitric oxide synthesis and a moderate inhibitor of the transcription factor NF-κB activation [9,10].Telekin affected activity of some antioxidant and drug-metabolizing enzymes in rat liver and kidney [11,12]. In a recently published report on antiproliferative and direct cytotoxic activity of extracts from T. speciosa an interference of these preparations with cell proliferation in vitro has been proven [13].…”

mentioning

confidence: 99%

Terpenoids from a multiple shoot culture of Telekia speciosa

Stojakowska¹,

Malarz²,

Kisiel³

2011

Acta Soc Bot Pol

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IntroductionHeartleaf oxeye [Telekia speciosa (Schreb.) Baumg., Asteraceae, tribe Inuleae, basionym -Buphtalmum speciosum Schreb.] is a perennial plant native to Southeastern Europe and Asia Minor. It is the only species belonging to the genus Telekia Baumg. [1], which, accordingly to recent molecular phylogenetic studies based on both cpDNA and ITS sequence analysis [2] is closely related to Carpesium spp. and a group of resiniferous taxa of Inula L., including Inula helenium -a well known medicinal plant. Likewise the roots of the resiniferous Inula species, roots of T. speciosa contain essential oil with eudesmane-type sesquiterpene lactones as major constituents. Except for sesquiterpene lactones of eudesmanolide and pseudoguaianolide type, the plant reportedly contains xanthanolides, terpenoid cyclopropenone derivatives, polyacetylene, thymol and nerol derivatives [3][4][5][6]. Data on medicinal uses of T. speciosa are sparse, however, biological activity of secondary metabolites produced by the plant have gained some interest. Except for widely investigated alantolactone and isoalantolactone, other sesquiterpene lactones -telekin and 2,3-dihydroaromaticin have also shown marked antiproliferative activity against human cancer cell lines in vitro [7,8]. Moreover, 2,3-dihydroaromaticin is a potent inhibitor of lipopolisaccharide induced nitric oxide synthesis and a moderate inhibitor of the transcription factor NF-κB activation [9,10].Telekin affected activity of some antioxidant and drug-metabolizing enzymes in rat liver and kidney [11,12]. In a recently published report on antiproliferative and direct cytotoxic activity of extracts from T. speciosa an interference of these preparations with cell proliferation in vitro has been proven [13].The aim of the present study was to achieve in vitro multiplication of T. speciosa shoots and to investigate secondary metabolism of the culture as a potential source of biologically active compounds. Material and methods Plant materialSeeds of Telekia speciosa (Schreb.) Baumg. were delivered by Botanical Garden in Nantes (France). Multiple shoots of the plant were collected from in vitro cultures maintained in our laboratory. As a reference material, aerial parts of Telekia speciosa (Schreb.) were harvested in July-August from plants grown in the Garden of Medicinal Plants, Institute of Pharmacology, Polish Academy of Sciences, Kraków, where a voucher specimen (10/08) was deposited. The plants were obtained by acclimatization of in vitro regenerated plantlets and were collected in the second year of their vegetation outside. AbstractMultiple shoots of Telekia speciosa were cultivated on MS medium containing 4.44 µM BAP and 0.54 µM NAA, solidified with agar. After eight weeks of culture the shoots were harvested and extracted with methanol. From the methanol extract one pseudoguaianolide -2,3-dihydroaromaticin and three thymol derivatives: 8-hydroxy-9,10-diisobutyryloxythymol, 10-isobutyryloxy-8,9-epoxythymyl isobutyrate and 10-(2-methylbutyryloxy)-8,9-epoxythymyl isobuty...

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Effect of Several Sesquiterpene Lactones on Lipid Peroxidation and Glutathione Level

Cited by 22 publications

References 18 publications

Helenalin bypasses Bcl-2-mediated cell death resistance by inhibiting NF-κB and promoting reactive oxygen species generation

Helenalin bypasses Bcl-2-mediated cell death resistance by inhibiting NF-κB and promoting reactive oxygen species generation

Medicinal Plants as Potential Source of Antioxidant Agents: A Review

Terpenoids from a multiple shoot culture of Telekia speciosa

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