Sesquiterpene lactones from<b><i>Saussurea alata</i></b>

Ren, Gang; Yu, Zhiguo; Chen, Y. L.; Wu, S. H.; Fu, Chenchen

doi:10.1080/14786410601130752

Cited by 17 publications

(6 citation statements)

References 11 publications

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“…Cynaropicrin has been also reported from the following botanical sources: The Chinese plant Saussurea katochaete (Asteraceae) (Saito et al, 2012), the aerial parts of Saussurea lipshitzii collected in South Gobi (Todorova et al, 1991), the aerial parts of Saussurea amurensis (Sham'yanov et al, 1988), Saussurea affinis (Das et al, 1983), S. salicifolia (Dudko and Rybalko, 1982), Saussurea costus (Pandey et al, 2007), and Saussurea alata (Ren et al, 2007). The aerial parts of Centaurea scoparia (Youssef and Frahm, 1994), Centaurea ptosimopappoides (Öksüz and Serin, 1997), Centaurea bella (Daniewski and Nowak, 1992), C. solstitialis (Merrill and Stevens, 1985), Centaurea pannonica (Heuff.)…”

Section: Sources Of Cynaropicrinmentioning

confidence: 99%

Cynaropicrin: A Comprehensive Research Review and Therapeutic Potential As an Anti-Hepatitis C Virus Agent

2016

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The different pharmacologic properties of plants-containing cynaropicrin, especially artichokes, have been known for many centuries. More recently, cynaropicrin exhibited a potential activity against all genotypes of hepatitis C virus (HCV). Cynaropicrin has also shown a wide range of other pharmacologic properties such as anti-hyperlipidemic, anti-trypanosomal, anti-malarial, antifeedant, antispasmodic, anti-photoaging, and anti-tumor action, as well as activation of bitter sensory receptors, and anti-inflammatory properties (e.g., associated with the suppression of the key pro-inflammatory NF-κB pathway). These pharmacological effects are very supportive factors to its outstanding activity against HCV. Structurally, cynaropicrin might be considered as a potential drug candidate, since it has no violations for the rule of five and its water-solubility could allow formulation as therapeutic injections. Moreover, cynaropicrin is a small molecule that can be easily synthesized and as the major constituent of the edible plant artichoke, which has a history of safe dietary use. In summary, cynaropicrin is a promising bioactive natural product that, with minor hit-to-lead optimization, might be developed as a drug for HCV.

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Section: Sources Of Cynaropicrinmentioning

confidence: 99%

Cynaropicrin: A Comprehensive Research Review and Therapeutic Potential As an Anti-Hepatitis C Virus Agent

2016

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“…The best activity was found for compound 162 with IC 50 of 13.0 and 8.7 lg/mL, respectively (Ren et al, 2007).…”

Section: Antitumor and Cytotoxicmentioning

confidence: 99%

Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

et al. 2013

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“…This screening identified cynaropicrin, a sesquiterpene lactone of the guaianolide type, as the most promising agent, worthy of further investigation. Cynaropicrin is highly concentrated in the edible plant artichoke (Cynara scolymus L.), where it is coresponsible for the characteristic bitter taste (Eljounaidi et al, 2015); however, it has also been isolated from several species of the genus Saussurea and Centaurea (Formisano et al, 2017a;Miloševi c Ifantis et al, 2013;Pandey, Rastogi, & Rawat, 2007;Ren, Yu, Chen, Wu, & Fu, 2007;Saito et al, 2012). Cynaropicrin has been shown to possess various bioactivities such as antihepatitis C virus, antihyperlipidemic, antiprotozoal, antifeedant, antispasmodic, antiphotoaging, as well as antitumor and antiinflammatory activities (Elsebai, Mocan, & Atanasov, 2016).…”

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confidence: 99%

Inhibitory effects of cynaropicrin on human melanoma progression by targeting MAPK, NF‐κB, and Nrf‐2 signaling pathways in vitro

Cicco

Busà

Ercolano

et al. 2020

Phytotherapy Research

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Malignant melanoma is the deadliest skin cancer, due to its propensity to metastasize. MAPKs and NF-κB pathways are constitutively activated in melanoma and promote cell proliferation, cell invasion, metastasis formation, and resistance to therapeutic regimens. Thus, they represent potential targets for melanoma prevention and treatment. Phytochemicals are gaining considerable attention for the management of melanoma because of their several cellular and molecular targets. A screening of a small library of sesquiterpenes lactones selected cynaropicrin, isolated from the aerial parts of Centaurea drabifolia subsp. detonsa, for its potential anticancer effect against melanoma cells. Treatment of human melanoma cells A375 with cynaropicrin resulted in inhibition of cell proliferation and induction of caspase-3-dependent apoptosis. Furthermore, cynaropicrin reduced several cellular malignant features such migration, invasion, and colonies formation through the inhibition of ERK1/2 and NF-κB activity. Cynaropicrin was able to reduce intracellular reactive oxygen species generation, which are involved in all the stages of carcinogenesis. Indeed, cynaropicrin increased the expression of several antioxidant genes, such as glutamate-cysteine ligase and heme oxygenase-1, by promoting the activation of the transcription factor Nrf-2. In conclusion, our results individuate cynaropicrin as a potential adjuvant chemotherapeutic agent for melanoma by targeting several protumorigenic signaling pathways.

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Sesquiterpene lactones fromSaussurea alata

Cited by 17 publications

References 11 publications

Cynaropicrin: A Comprehensive Research Review and Therapeutic Potential As an Anti-Hepatitis C Virus Agent

Cynaropicrin: A Comprehensive Research Review and Therapeutic Potential As an Anti-Hepatitis C Virus Agent

Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

Inhibitory effects of cynaropicrin on human melanoma progression by targeting MAPK, NF‐κB, and Nrf‐2 signaling pathways in vitro

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