“…This screening identified cynaropicrin, a sesquiterpene lactone of the guaianolide type, as the most promising agent, worthy of further investigation. Cynaropicrin is highly concentrated in the edible plant artichoke (Cynara scolymus L.), where it is coresponsible for the characteristic bitter taste (Eljounaidi et al, 2015); however, it has also been isolated from several species of the genus Saussurea and Centaurea (Formisano et al, 2017a;Miloševi c Ifantis et al, 2013;Pandey, Rastogi, & Rawat, 2007;Ren, Yu, Chen, Wu, & Fu, 2007;Saito et al, 2012). Cynaropicrin has been shown to possess various bioactivities such as antihepatitis C virus, antihyperlipidemic, antiprotozoal, antifeedant, antispasmodic, antiphotoaging, as well as antitumor and antiinflammatory activities (Elsebai, Mocan, & Atanasov, 2016).…”