Sesquiterpene lactones and scopoletins from Artemisia scoparia Waldst. & Kit. and their angiotensin I-converting enzyme inhibitory activities

Abstract

Ten compounds, including a new guaiane-type sesquiterpene lactone, were isolated from the aerial parts of . The structure of the new compound was determined to be 5-hydroxyguaia-3(4),11(13),10(14)-trien-6α,12-olide, named scoparanolide. Six known sesquiterpene lactones [estafiatone, 3β,4α-dihydroxyguaia-11(13),10(14)-dien-6α,12-olide, estafiatin, preeupatundin, 3β-hydroxycostunolide, and ludovicin B] and three known coumarin derivatives (scopoletin, scoparone, and isofraxidin) were identified by nuclear magnetic resonance and electrospray ionization mass spectroscopy. Six known sesquiterpene lactones were found for the first time in this plant. The angiotensin I-converting enzyme inhibitory activities of coumarin derivatives and scopoletins were significantly higher compared to those of sesquiterpene lactones and quercetin.

Artemisia scoparia attenuates amyloid β accumulation and tau hyperphosphorylation in spontaneously hypertensive rats

“…Artemisia scoparia (AS; redstem wormwood, Asteraceae) is an edible halophyte with a unique aroma and bitter taste. Several chemical constituents, such as scopariachromane, coumarins, flavonoids, sterols, and sesquiterpene lactones, have been isolated from this plant [8,9]. Recently, various biological effects of the extracts, including antioxidant, anti-inflammatory, antipyretic, and liver protective activities, have been demonstrated [9][10][11].…”

The First Report on Chemical Composition and Antimicrobial Activity of Artemisia scoparia Waldst. et Kit. Extracts

“…In both DE and EE, the main compound was scoparone (DE 24.0%; EE 86.1%). Scoparone was previously isolated from A. scoparia [16][17][18][19][20][21] but was also found in some other species of this genus. Among others scoparone was found in A. capillaris, [22][23][24] A. annua, 25,26 and A. dracunculus.…”

Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties

“…Cho and co-workers, in two separate studies on Artemisia scoparia, demonstrated the effectiveness of purified IF (1 mM) on the blockade of ACE activity (69.0%). Also IF isolated during the EtOAc and chloroform extraction of aerial parts of Artemisia scoparia, showed ACE inhibitory effects at 26.1% and 30.6%, respectively [59,136]. On the other hand, Simaratanamongkol and co-workers demonstrated the synergistic effects of IF isolated from Apium graveolens, with junipediol A on the inhibition of ACE.…”

“…Artemisia incisa Asteraceae aerial parts [56] Artemisia abrotanum Asteraceae aerial parts [57] Artemisia keiskeana Asteraceae whole plant [58] Artemisia scoparia Asteraceae aerial parts [59] Artemisia selengensis Asteraceae aerial parts [60] Impatiens balsamina Balsaminaceae root [61] Chimonanthus salicifolius Calycanthaceae aerial parts [62] Chloranthus anhuiensis Chlorantaceae whole plant [63] Chloranthus japonicus Chlorantaceae root [39] Daboecia cantabrica Ericaceae flower [21] Erica spp Ericaceae flower [21] Euphorbia lagascae Euphorbiaceae seed [64] Fraxinus exelsior Oleaceae bark [65] Fraxinus japonicus Oleaceae bark [66] Fraxinus ornus Oleaceae bark, flowers, leaves [67] Greenea corymbose Rubiaceae stem bark, leaves [43] Greenea montana Rubiaceae stem bark, root bark, leaves [43] Ixora cibdela Rubiaceae stem bark, root bark [68] Ixora javanica Rubiaceae stem bark, root bark [43] Morus alba Moraceae leaves [69] Micrandra elata Euphorbiaceae twig [70] Pelargonium reniforme Geraniaceae root [71] Peucedanum praeruptorum Apiaceae root [72] Rhododendron rubiginosum Ericaceae leaves [73] Ruyschia phylladenia Marcgraviaceae bark [29] Saposhnikovia divaricata Apiaceae root [74] Sarcandra glabra Chloranthaceae whole plant [75] Sapium discolor Euphorbiaceae stem, leaves [76] Solanum indicum Solanaceae seed [77] 2.…”