Artemisia scoparia attenuates amyloid β accumulation and tau hyperphosphorylation in spontaneously hypertensive rats

Promyo, Kitipong; Cho, Jeong-Yong; Park, Kyung-Hee; Jaiswal, Lily; Park, Sunyoung; Ham, Kyung‐Sik

doi:10.1007/s10068-017-0077-3

Cited by 9 publications

(8 citation statements)

References 36 publications

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“…These promising results are in contrast to the previous results obtained for the Artemisia species, where the IC 50 ranged from 100 to 200 µg/mL [ 51 ]. This potent effect could be attributed to the different chemical profiling of our EOs, especially the presence of tocopherol derivatives in EOAS as well as the occurrence of oleic acid in the EOAA.…”

Section: Resultscontrasting

confidence: 97%

Phytochemical Profiling, Antioxidant, Antimicrobial and Cholinesterase Inhibitory Effects of Essential Oils Isolated from the Leaves of Artemisia scoparia and Artemisia absinthium

Khan

Ahmad

et al. 2022

Pharmaceuticals

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The current studies were focused on the phytochemical profiling of two local wild Artemisia species, Artemisia scoparia and Artemisia absinthium leaves' essential oils, extracted via the hydro distillation method along with evaluation of their antioxidant as well as antimicrobial effects. The constituents of EOs were identified using a combined gas chromatography-mass spectrometric (GC-MS) technique. A total of 25 compounds in A. scoparia essential oil (EOAS) were identified, and 14 compounds with percentage abundance of >1% were tabulated, the major being tocopherol derivatives (47.55%). A total of nine compounds in Artemisia absinthium essential oil (EOAA) were enlisted (% age >1%), the majority being oleic acid derivatives (41.45%). Strong antioxidant effects were pronounced by the EOAS in DPPH (IC50 = 285 ± 0.82 µg/mL) and in ABTS (IC50 = 295 ± 0.32 µg/mL) free radical scavenging assays. Both the EOs remained potent in inhibiting the growth of bacterial species; Escherichia coli (55–70%) and Shigella flexneri (60–75%) however remained moderately effective against Bacillus subtilis as well as Staphylococcus aureus. Both EOAS and EOAA strongly inhibited the growth of the tested fungal species, especially Aspergillus species (up to 70%). The oils showed anti-cholinesterase potential by inhibiting both Acetylcholinesterase (AChE; IC50 = 30 ± 0.04 µg/mL (EOAS), 32 ± 0.05 µg/mL (EOAA) and Butyrylcholinesterase (BChE; IC50 = 34 ± 0.07 µg/mL (EOAS), 36 ± 0.03 µg/mL (EOAA). In conclusion, the essential oils of A. scoparia and A. absinthium are promising antioxidant, antimicrobial and anticholinergic agents with a different phytochemical composition herein reported for the first time.

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Section: Resultscontrasting

confidence: 97%

Phytochemical Profiling, Antioxidant, Antimicrobial and Cholinesterase Inhibitory Effects of Essential Oils Isolated from the Leaves of Artemisia scoparia and Artemisia absinthium

Khan

Ahmad

et al. 2022

Pharmaceuticals

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“…This species also has renal-protective [5], hepato-protective [14], hypo-lipidemic [15], and urease inhibitory [16] properties. Moreover, it has been utilized for curing Alzheimer’s disease [17].…”

Section: Introductionmentioning

confidence: 99%

Chloroplast Genome Sequence of Artemisia scoparia: Comparative Analyses and Screening of Mutational Hotspots

Iram

Hayat

Tahir

et al. 2019

Plants

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Artemisia L. is among the most diverse and medicinally important genera of the plant family Asteraceae. Discrepancies arise in the taxonomic classification of Artemisia due to the occurrence of multiple polyploidy events in separate lineages and its complex morphology. The discrepancies could be resolved by increasing the genomic resources. A. scoparia is one of the most medicinally important species in Artemisia. In this paper, we report the complete chloroplast genome sequence of Artemisia scoparia. The genome was 151,060 bp (base pairs), comprising a large single copy (82,834 bp) and small single copy (18,282 bp), separated by a pair of long inverted repeats (IRa and IRb: 24,972 bp each). We identified 114 unique genes, including four ribosomal RNAs, 30 transfer RNAs, and 80 protein-coding genes. We analysed the chloroplast genome features, including oligonucleotide repeats, microsatellites, amino acid frequencies, RNA editing sites, and codon usage. Transversion substitutions were twice as frequent as transition substitutions. Mutational hotspot loci included ccsA-ndhD, trnH-psbA, ndhG-ndhI, rps18-rpl20, and rps15-ycf1. These loci can be used to develop cost-effective and robust molecular markers for resolving the taxonomic discrepancies. The reconstructed phylogenetic tree supported previous findings of Artemisia as a monophyletic genus, sister to the genus Chrysanthemum, whereby A. scoparia appeared as sister to A. capillaris.

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“…A. scoparia has a well-documented history of medicinal use (12,13), and it has been shown to have a wide range of effects in disease models related to Alzheimer disease, renal oxidative stress, hepatotoxicity, hypertension, and others (14)(15)(16)(17). More specifically, anti-inflammatory effects of A. scoparia have been described in a wide range of cell types and contexts (18)(19)(20).…”

Section: Original Articlementioning

confidence: 99%

Mechanisms of Artemisia scoparia’s Anti‐Inflammatory Activity in Cultured Adipocytes, Macrophages, and Pancreatic β‐Cells

Boudreau

Burke

Collier

et al. 2020

Obesity

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Objective An ethanolic extract of Artemisia scoparia (SCO) improves adipose tissue function and reduces negative metabolic consequences of high‐fat feeding. A. scoparia has a long history of medicinal use across Asia and has anti‐inflammatory effects in various cell types and disease models. The objective of the current study was to investigate SCO’s effects on inflammation in cells relevant to metabolic health. Methods Inflammatory responses were assayed in cultured adipocytes, macrophages, and insulinoma cells by quantitative polymerase chain reaction, immunoblotting, and NF‐κB reporter assays. Results In tumor necrosis factor α–treated adipocytes, SCO mitigated ERK and NF‐κB signaling as well as transcriptional responses but had no effect on fatty acid–binding protein 4 secretion. SCO also reduced levels of deleted in breast cancer 1 protein in adipocytes and inhibited inflammatory gene expression in stimulated macrophages. Finally, in pancreatic β‐cells, SCO decreased NF‐κB–responsive promoter activity induced by IL‐1β treatment. Conclusions SCO’s ability to promote adipocyte development and function is thought to mediate its insulin‐sensitizing actions in vivo. Our findings that SCO inhibits inflammatory responses through at least two distinct signaling pathways (ERK and NF‐κB) in three cell types known to contribute to metabolic disease reveal that SCO may act more broadly than previously thought to improve metabolic health.

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Artemisia scoparia attenuates amyloid β accumulation and tau hyperphosphorylation in spontaneously hypertensive rats

Cited by 9 publications

References 36 publications

Phytochemical Profiling, Antioxidant, Antimicrobial and Cholinesterase Inhibitory Effects of Essential Oils Isolated from the Leaves of Artemisia scoparia and Artemisia absinthium

Phytochemical Profiling, Antioxidant, Antimicrobial and Cholinesterase Inhibitory Effects of Essential Oils Isolated from the Leaves of Artemisia scoparia and Artemisia absinthium

Chloroplast Genome Sequence of Artemisia scoparia: Comparative Analyses and Screening of Mutational Hotspots

Mechanisms of Artemisia scoparia’s Anti‐Inflammatory Activity in Cultured Adipocytes, Macrophages, and Pancreatic β‐Cells

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