Sesquiterpene evoninate alkaloids from Tripterygium hypoglaucum

Sesquiterpene Alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: A New Class of Potent Anti-HIV Agents

“…Its 1 H NMR spectral data revealed the presence of four acetyl groups (δ H 1.75, 1.90, 2.10, and 2.18), two methylene groups [δ H 4.21, 5.41 (2H, d, J ) 14.2 Hz); 3.65, 5.95 (2H, d, J ) 11.7 Hz)], and seven methine protons [δ H 2.43, 4.65, 5.15, 5.25, 5.42, 5.46, and 7.02], as well as a 2,3-disubstituted pyridine [δ H 7.20 (1H,dd,J ) 4.9,7.8 Hz), 8.01 (1H, dd, J ) 1. 5,7.8 Hz), and 8.62 (1H, dd, J ) 1. 5, 4.9 Hz)], two secondary methyl groups [δ H 1.10 and 1.32], and two coupled methine protons [δ H 2.48 and 4.60].…”

Terpenoids from Tripterygium hypoglaucum and their inhibition of LPS-induced NO production

“…In summary, one new (1) and three known (2-4) sesquiterpenes and four diterpenes (5)(6)(7)(8) were successfully isolated from the root bark of T. hypoglaucum. Their structures were elucidated by 1D-and 2D-NMR spectra.…”

“…As a continuation of our work on the search for bioactive natural products, 9−13) the root bark of T. hypoglaucum, a traditional medicine, evoked our interest, whose bioactive constituents responsible for anti-inflammation had not been investigated. Our chemical investigation isolated one new (1) and three known (2-4) sesquiterpenes and four known diterpenes (5)(6)(7)(8) from the root bark of T. hypoglaucum. Their structures were elucidated as 9α-cinnamoyloxy-1β-furoyloxy-4-hydroxy-6α-nicotino yloxy-β-dihydroagarofuran (1), 1β,9α-dibenzoyloxy-4-hydroxy-6α-nicotinoyloxy-β-dihydroagarofuran (2), 1β-benzoyloxy-9α-cinnamoyloxy-4-hydroxy-6α-nicotinoy loxy-β-dihydroagarofuran (3), 1β-acetoxy-9α-benzoyloxy-4-hydroxy-6α-nicotinoyloxy-β-dihydroagarofuran (4), hypolide (5), neotriptophenolide (6), triptobenzene A (7), and triptonediol (8) (Fig.…”

A New Insecticidal Sesquiterpene Ester from Celastrus Angulatus

“…Various β-dihydroagarofuran sesquiterpene polyol esters and pyridine alkaloids, some of which exhibit insect antifeedant, insecticidal, antitumor, reversing multidrug resistance, anti-HIV, and immunosuppressive activities, have been obtained from the plants of the Celastraceae family [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Celastrus angulatus , a plant of the this family, is widely distributed in China and used for the treatment of rheumatism in traditional Chinese medicine and as an insecticide [ 11 , 12 ].…”