Sesquiterpene coumarin ethers from the genus Heptaptera

Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica

“…Several coumarin derivatives have been isolated from Heptaptera species [2][3][4]. The antioxidant capacity and AChE inhibitory activity of the extracts of these species were reported previously [5].…”

Cytotoxic activity of the root and fruit extracts of heptaptera anisoptera (dc.) tutin

“…The cytotoxic activities observed with these extracts are shown in Table 1. , colladin, 14-acetoxybadrakemin, 14-acetoxybadrakemone, 14-hydroxycolladonin from the chloroform extract of the roots and more polar compounds samarcandin, samarcandone, conferol, conferone, feselol, 9,10,11-trihydroxyumbelliprenin, 9,10,11-5'-tetrahydroxyumbelliprenin, 9, 10, 5'-triacetoxy-11-hydroxyumbellipreni, 10, 11, 5'-trihydroxyumbelliprenin from the chloroform extract of the fruits of H. anisoptera collected from Diyarbakır in June 1991 3,11,12 . Cytotoxic activity of certain sesquiterpene coumarins were described earlier 4,5 , thus, the cytotoxic compound(s) of the roots and fruits of H. anisoptera may be this type of compound(s).…”

Preliminary screening of acetylcholinesterase inhibitory and antioxidant activities of AnatolianHeptapteraspecies

“…Heptaptera species are known to be rich in coumarin derivatives, sesquiterpene coumarin ether types in particular (Crowden et al, 1969;Appendino et al, 1992bAppendino et al, , 1993. Coumarins having a basic benzo-2-pyrone skeleton are one of the simplest groups of phenolic compounds and have been reported to have strong antioxidant effect by various mechanisms including DPPH and hydroxyl radical scavenging activity, inhibition of lipid peroxidation, metal chelating, etc.…”

“…Tutin (Davis, 1972(Davis, , 1988Güner et al, 2000). Although limited phytochemical study has been so far carried on the Heptaptera species, the genus has been reported to be rich in coumarin derivatives; i.e., mangiferin, colladin, colladonin, badrakemin, 5,7-dihydroxycoumarin, and umbelliprenin derivatives (Simova et al, 1986;Appendino et al, 1992aAppendino et al, , 1992bAppendino et al, , 1993.…”