Preliminary screening of acetylcholinesterase inhibitory and antioxidant activities of Anatolian<i>Heptaptera</i>species

Five sesquiterpene coumarin ethers: umbelliprenin, umbelliprenin-10',11'-monoepoxide, conferone, mogoltacin and feselol were isolated from the fruits of Heptaptera cilicica. Their structures were identified by means of spectroscopic methods. AChE and BuChE inhibitory activities of the compounds were determined by molecular docking method which were confirmed by in vitro experiments. According to molecular docking results, total score of feselol and umbelliprenin were 5.69 and 3.23 kcal/mol against acetylcholinesterase, respectively. Total score for butyrylcholinesterase inhibitory effect of them were 2.76 and 4.99 kcal/mol, respectively. Feselol and umbelliprenin exhibited significantly high inhibitory potency against acetylcholinesterase (IC 50 = 1.26 ± 0.01 and 5.86 ± 0.03 μM, respectively) and butyrylcholinesterase (IC 50 = 9.98 ± 0.24 and 1.10 ± 0.19 μM, respectively). This is the first report of isolation of natural bioactives obtained from the chloroform extract of Heptaptera cilicica fruits with anticholinesterase activity.

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“…The antioxidant capacity and AChE inhibitory activity of the extracts of these species were reported previously [5].…”

Section: Previous Studiesmentioning

confidence: 80%

Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica

Güvenalp¹,

Özbek²,

Yerdelen³

et al. 2017

Rec.Nat.Prod.

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“…In conclusion, our results showed that H. triquetra showed the best radical scavenging and iron chelating effects among the extracts and could be a potential source for antioxidant compounds; while H. anatolica may be worthy of further phytochemical characterization for its anticholinesterase effect. To the best of our knowledge, this is the first report on anticholinesterase and antioxidant activities of Heptaptera species [3].…”

Section: Apiaceaementioning

confidence: 83%

“…The genus Heptaptera (Apiaceae) possesses 10 [3]. Heptaptera species are known to be rich in coumarin derivatives, sesquiterpene coumarin ether types in particular.…”

Section: Apiaceaementioning

confidence: 99%

Exploring Turkish biodiversity: A rich source of chemical diversity for drug leads discovery

Şener

Orhan

2011

Pure and Applied Chemistry

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Bioresources offer tremendous potential by having excellent chemical diversity for drug discovery programs and by serving as templates for synthetic drugs. There are wellknown examples of clinically important drugs derived from natural sources. The development of pharmaceutical, nutraceutical, agricultural, and industrial products from bioresources can be used to promote incentives for conservation by providing an economic return to innovative use. Of those sources, medicinal plants have a virtually untapped reserve of original drug molecules, which await determination and chemical and biological investigation. Marine organisms have also gained increasing attention from researchers worldwide due to their chemically diverse secondary metabolites with desirable biological activities.There is still a great need for novel compounds with unique mechanisms of action to treat diseases such as cancer, Alzheimer's, arthritis, and diabetes. Besides, multiresistance development by the parasites to the present drugs also constitutes another problem for the treatment of parasitic diseases as well as tuberculosis.In this article, 209 plant species belonging to 11 plant families were investigated for cholinesterase inhibitory activity by in vitro Ellman method at 10 μg/ml and 1 mg/ml doses. Among them, Salvia, Rosmarinus, and Fumaria species were found to have the most significant cholinesterase inhibitory activity.

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“…Türkiye de doğal olarak yetişen 4 Heptaptera türünün meyvelerinden elde edilen uçucu yağlar gaz kromotografisi (GS), gaz kromatografisi/kütle kromatoğrafisi (GS/MS) analizleriyle incelenmiş ve kimyasal yapıları aydınlatılmıştır [17]. Diğer bir çalışmada ise Heptaptera türlerinin asetilkolin esteraz-antioksidan aktivite çalışması yapılmış ve anlamlı sonuçlar elde edilmiştir [18]. Apiaceae familyası bitkilerinin meyve özellikleri taksonomik açıdan önemli olup, türlerin ayrımında kullanılan temel bir karakterdir.…”

Section: Introductionunclassified

Türkiye’de yetişen Heptaptera marg. & reuter (Apiaceae) türlerinin meyve morfolojisi ve anatomisi

KAYA¹

2016

Ankara Üniversitesi Eczacılık Fakültesi Dergisi

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Preliminary screening of acetylcholinesterase inhibitory and antioxidant activities of AnatolianHeptapteraspecies

Cited by 19 publications

References 16 publications

Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica

Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica

Exploring Turkish biodiversity: A rich source of chemical diversity for drug leads discovery

Türkiye’de yetişen Heptaptera marg. & reuter (Apiaceae) türlerinin meyve morfolojisi ve anatomisi

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