SESN2-Mediated AKT/GSK-3β/NRF2 Activation to Ameliorate Adriamycin Cardiotoxicity in High-Fat Diet–Induced Obese Mice

Gao, Ting; B, Jie Wang; Xiao, Mengjie; A, Jie Wang; Wang, Shudong; Tang, Yufeng; Zhang, Jingjing; Lu, Guangping; Guo, Hua; Guo, Yuanfang; Liu, Qingbo; Li, Jiahao; Gu, Junlian

doi:10.1089/ars.2022.0156

Cited by 3 publications

(3 citation statements)

References 74 publications

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“…Nine records that were excluded during the first screening used the terminology of stress cardiomyopathy, although not implying to TS. These records employed this terminology to study the effects of reductive stress ( 66 ), exertional heat stroke ( 67 ), subarachnoid haemorrhage ( 68 ), settings of catecholamine excess ( 69 ), physiological disturbances ( 70 ), toxicity ( 71 ), etc., on the heart. However, while both subarachnoid haemorrhage and exogenous catecholamine administration can be used as induction methods for a TS model, their presence does not necessarily implicate TS.…”

Section: Animal Models Of Takotsubo Syndromementioning

confidence: 99%

Animal models of Takotsubo syndrome: bridging the gap to the human condition

Zulfaj,

Nejat,

Haamid

et al. 2024

Front. Cardiovasc. Med.

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Modelling human diseases serves as a crucial tool to unveil underlying mechanisms and pathophysiology. Takotsubo syndrome (TS), an acute form of heart failure resembling myocardial infarction, manifests with reversible regional wall motion abnormalities (RWMA) of the ventricles. Despite its mortality and clinical similarity to myocardial infarction, TS aetiology remains elusive, with stress and catecholamines playing central roles. This review delves into current animal models of TS, aiming to assess their ability to replicate key clinical traits and identifying limitations. An in-depth evaluation of published animal models reveals a variation in the definition of TS among studies. We notice a substantial prevalence of catecholamine-induced models, particularly in rodents. While these models shed light on TS, there remains potential for refinement. Translational success in TS research hinges on models that align with human TS features and exhibit the key features, including transient RWMA. Animal models should be comprehensively evaluated regarding the various systemic changes of the applied trigger(s) for a proper interpretation. This review acts as a guide for researchers, advocating for stringent TS model standards and enhancing translational validity.

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Section: Animal Models Of Takotsubo Syndromementioning

confidence: 99%

Animal models of Takotsubo syndrome: bridging the gap to the human condition

Zulfaj,

Nejat,

Haamid

et al. 2024

Front. Cardiovasc. Med.

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“…Previous research has indicated that upregulation of sestrin2 during oxidative stress can lead to the degradation of Keap1 through autophagy, resulting in the breakdown of Nuclear factor erythroid2‐related factor 2 (Nrf2) 11 . Gao et al demonstrated that sestrin2 ameliorated adriamycin cardiotoxicity in high‐fat diet‐induced obese mice via mediated AKT/GSK3β/Nrf2 activation 12 . In addition, sestrin2 inhibits corneal epithelial cell proliferation 13 .…”

Section: Introductionmentioning

confidence: 99%

“…11 Gao et al demonstrated that sestrin2 ameliorated adriamycin cardiotoxicity in high-fat dietinduced obese mice via mediated AKT/GSK3β/Nrf2 activation. 12 In addition, sestrin2 inhibits corneal epithelial cell proliferation. 13 Previous studies indicated that the upregulation of sestrin2 could reduce metabolic stress induced by hyperglycemia, 14 protect the blood-retinal barrier.…”

mentioning

confidence: 99%

The impact of sestrin2 on reactive oxygen species in diabetic retinopathy

Yang,

2024

Cell Biochemistry & Function

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Diabetic retinopathy (DR) is a significant complication of diabetes that often leads to blindness, impacting Müller cells, the primary retinal macroglia involved in DR pathogenesis. Reactive oxygen species (ROS) play a crucial role in the development of DR. The objective of this study was to investigate the involvement of sestrin2 in DR using a high‐glucose (HG)‐induced Müller cell model and assessing cell proliferation with 5‐ethynyl‐2‐deoxyuridine (EdU) labeling. Following this, sestrin2 was upregulated in Müller cells to investigate its effects on ROS, tube formation, and inflammation both in vitro and in vivo, as well as its interaction with the nuclear factor erythroid2‐related factor 2 (Nrf2) signaling pathway. The findings demonstrated a gradual increase in the number of EdU‐positive cells over time, with a subsequent decrease after 72 h of exposure to high glucose levels. Additionally, the expression of sestrin2 exhibited a progressive increase over time, followed by a decrease at 72 h. The rh‐sestrin2 treatment suppressed the injury of Müller cells, decreased ROS level, and inhibited the tube formation. Rh‐sestrin2 treatment enhanced the expression of sestrin2, Nrf2, heme oxygenase‐1 (HO‐1), and glutamine synthetase (GS); however, the ML385 treatment reversed the protective effect of rh‐sestrin2. Finally, we evaluated the effect of sestrin2 in a DR rat model. Sestrin2 overexpression treatment improved the pathological injury of retina and attenuated the oxidative damage and inflammatory reaction. Our results highlighted the inhibitory effect of sestrin2 in the damage of retina, thus presenting a novel therapeutic sight for DR.

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Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity

Li,

Tang,

et al. 2024

Journal of Advanced Research

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SESN2-Mediated AKT/GSK-3β/NRF2 Activation to Ameliorate Adriamycin Cardiotoxicity in High-Fat Diet–Induced Obese Mice

Cited by 3 publications

References 74 publications

Animal models of Takotsubo syndrome: bridging the gap to the human condition

Animal models of Takotsubo syndrome: bridging the gap to the human condition

The impact of sestrin2 on reactive oxygen species in diabetic retinopathy

Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity

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