Sesamol alleviates diet-induced cardiometabolic syndrome in rats via up-regulating PPARγ, PPARα and e-NOS

Peroxisome proliferator activated receptors (PPARs) α, -γ and -β/δ are ligand-activated transcription factors and members of the superfamily of nuclear hormone receptor. These receptors play key roles in maintaining glucose and lipid homeostasis by modulating gene expression. PPARs constitute a recognized druggable target and indeed several classes of drugs used in the treatment of metabolic disease symptoms, such as dyslipidemia (fibrates, e.g. fenofibrate and gemfibrozil) and diabetes (thiazolidinediones, e.g. rosiglitazone and pioglitazone) are ligands for the various PPAR isoforms. More precisely, antidiabetic thiazolidinediones act on PPARγ, while PPARα is the main molecular target of antidyslipidemic fibrates. Over the past few years, our understanding of the mechanism underlying the PPAR modulation of gene expression has greatly increased. This review presents a survey on terrestrial and marine natural products modulating the PPARα system with the objective of highlighting how the incredible chemodiversity of natural products can provide innovative leads for this “hot” target.

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“…The biosynthetically and chemically related sesamol ( 32 ), also present in sesame seed oil, share this effect 48 .…”

Section: Natural Products Modulating Pparαmentioning

confidence: 99%

The potential of natural products for targeting PPAR α

Rigano

Sirignano

Taglialatela‐Scafati

2017

Acta Pharmaceutica Sinica B

125

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“…Sesamol was also reported to be an inhibitor of lipid metabolism in fungi and yeasts . Various literatures in recent years indicated that sesamol prevented diet, isoproterenol, or doxorubicin induced cardiometabolic syndrome via improving lipid profiles in tissues or serum in animal models . Sesamol was also demonstrated to alleviate a high‐fat diet induced hyperlipidemia and atherosclerosis by reducing plasma TG and cholesterol in rodent models .…”

Section: Introductionmentioning

confidence: 99%

Sesamol ameliorates diet‐induced obesity in C57BL/6J mice and suppresses adipogenesis in 3T3‐L1 cells via regulating mitochondria‐lipid metabolism

Liu

Qiao

Sun

et al. 2017

Molecular Nutrition Food Res

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“…The therapeutic effects of sesame oil on LVH in DOCA/salt‐induced hypertension may be attributable to its components, such as phenolic lignans (sesamin and sesamol) and vitamin E. Sesamol has effectively decreased blood pressure in rats with diet‐induced cardiometabolic syndrome 24 . Sesamin has attenuated the development of hypertension and cardiovascular impairment in the DOCA/salt hypertensive rat 23 .…”

Section: Discussionmentioning

confidence: 99%

“…Sesame oil is a potent natural antioxidant 20 – 22 . The phenolic lignans from sesame oil, such as sesamin, sesamol, and sesamolin, contribute to its antioxidative activities 23 – 25 . The antioxidative effects of sesamin or sesamol have alleviated hypertension in various animal models 23 , 24 .…”

Section: Introductionmentioning

confidence: 99%