Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans

Nakatani, Yumiko; Yaguchi, Yukie; Komura, Tomomi; Nakadai, Masakazu; Terao, Kenji; Kage-Nakadai, Eriko; Nishikawa, Yoshikazu

doi:10.1007/s00394-017-1396-0

Cited by 19 publications

(11 citation statements)

References 56 publications

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“…Among the lignans of sesame, sesamin has been investigated most often for antiaging effects. Sesamin extended the life span in the fruit fly Drosophila melanogaster [340] and the nematode Caenorhabditis elegans [341,342]. In D. melanogaster mutant depleted of superoxide dismutase, which exhibits a shortened lifespan and accelerated aging-related phenotype, sesamin extended the life span, suppressed the decline of motoric activities, and delayed aging-related loss of dopaminergic neurons in the brain [343].…”

Section: Antiaging Effectsmentioning

confidence: 99%

Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

et al. 2021

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Major lignans of sesame sesamin and sesamolin are benzodioxol--substituted furofurans. Sesamol, sesaminol, its epimers, and episesamin are transformation products found in processed products. Synthetic routes to all lignans are known but only sesamol is synthesized industrially. Biosynthesis of furofuran lignans begins with the dimerization of coniferyl alcohol, followed by the formation of dioxoles, oxidation, and glycosylation. Most genes of the lignan pathway in sesame have been identified but the inheritance of lignan content is poorly understood. Health-promoting properties make lignans attractive components of functional food. Lignans enhance the efficiency of insecticides and possess antifeedant activity, but their biological function in plants remains hypothetical. In this work, extensive literature including historical texts is reviewed, controversial issues are critically examined, and errors perpetuated in literature are corrected. The following aspects are covered: chemical properties and transformations of lignans; analysis, purification, and total synthesis; occurrence in Seseamum indicum and related plants; biosynthesis and genetics; biological activities; health-promoting properties; and biological functions. Finally, the improvement of lignan content in sesame seeds by breeding and biotechnology and the potential of hairy roots for manufacturing lignans in vitro are outlined.

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Section: Antiaging Effectsmentioning

confidence: 99%

Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

et al. 2021

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“…PMK-1 is a kinase that plays an important role in immune defense and longevity in the MAPK pathway. In addition, sesamin can also act as a mimic of DR. Sesamin depends on SIR-2.1/SIRT1, AAK-2/AMPK, an autophagic modulator BEC-1, and daf-15 , which encodes the target of TOR-binding partner raptor, to promote longevity (Yaguchi et al, 2014 ; Nakatani et al, 2018 ). The inhibition of the TOR pathway is another well-known intervention method to prolong lifespan.…”

Section: Lignansmentioning

confidence: 99%

The Review of Anti-aging Mechanism of Polyphenols on Caenorhabditis elegans

Liu

Guo

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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Micronutrients extracted from natural plants or made by biological synthesis are widely used in anti-aging research and applications. Among more than 30 effective anti-aging substances, employing polyphenol organic compounds for modification or delaying of the aging process attracts great interest because of their distinct contribution in the prevention of degenerative diseases, such as cardiovascular disease and cancer. There is a profound potential for polyphenol extracts in the research of aging and the related diseases of the elderly. Previous studies have mainly focused on the properties of polyphenols implicated in free radical scavenging; however, the anti-oxidant effect cannot fully elaborate its biological functions, such as neuroprotection, Aβ protein production, ion channel coupling, and signal transduction pathways. Caenorhabditis elegans (C. elegans) has been considered as an ideal model organism for exploring the mechanism of anti-aging research and is broadly utilized in screening for natural bioactive substances. In this review, we have described the molecular mechanisms and pathways responsible for the slowdown of aging processes exerted by polyphenols. We also have discussed the possible mechanisms for their anti-oxidant and anti-aging properties in C. elegans from the perspective of different classifications of the specific polyphenols, such as flavonols, anthocyanins, flavan-3-ols, hydroxybenzoic acid, hydroxycinnamic acid, and stilbenes.

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“…Sesamin is derived from sesame seeds and exerts antiaging effects (Yaguchi et al., 2014). Sesamin supplementation eliminates the lifespan extension of daf‐15 (which encodes the target of TOR‐binding partner Raptor) and aak‐2 mutants, indicating that several DR‐related signaling pathways, including SIRT1, TOR, and AMPK, mediate the antiaging effect of sesamin in nematodes (Nakatani et al., 2018).…”

Section: Caenorhabditis Elegans As a Powerful Model For Antiaging Evamentioning

confidence: 99%

Potential of Caenorhabditis elegans as an antiaging evaluation model for dietary phytochemicals: A review

Sun

2020

Comp Rev Food Sci Food Safe

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Aging is an inevitable process characterized by the accumulation of degenerative damage, leading to serious diseases that affect human health. Studies on aging aim to develop pre-protection or therapies to delay aging and age-related diseases. A preventive approach is preferable to clinical treatment not only to reduce investment but also to alleviate pain in patients. Adjusting daily diet habits to improve the aging condition is a potentially attractive strategy. Fruits and vegetables containing active compounds that can effectively delay the aging process and reduce or inhibit age-related degenerative diseases have been identified. The signaling pathways related to aging in Caenorhabditis elegans are evolutionarily conserved; thus, studying antiaging components by intervening senescence process may contribute to the prevention and treatment of age-related diseases in humans. This review focuses on the effects of food-derived extracts or purified substance on antiaging in nematodes, as well as the underlying mechanisms, on the basis of several major signaling pathways and key regulatory factors in aging. The aim is to provide references for a healthy diet guidance and the development of antiaging nutritional supplements. Finally, challenges in the use of C. elegans as the antiaging evaluation model are discussed, together with the development that potentially inspire novel strategies and research tools.

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Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans

Abstract: Sesamin extends the lifespan of C. elegans through several dietary restriction-related signaling pathways, including processes requiring SIRT1, TOR, and AMPK.

Cited by 19 publications

References 56 publications

Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

The Review of Anti-aging Mechanism of Polyphenols on Caenorhabditis elegans

Potential of Caenorhabditis elegans as an antiaging evaluation model for dietary phytochemicals: A review

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