Sesamin ameliorates lipopolysaccharide/d-galactosamine-induced fulminant hepatic failure by suppression of Toll-like receptor 4 signaling in mice

Ma, Li; Gong, Xia; Kuang, Ge; Jiang, Rong; Chen, Rongchun; Wan, Jingyuan

doi:10.1016/j.bbrc.2015.03.154

Cited by 29 publications

(16 citation statements)

References 32 publications

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“…Ghrelin also improves the histopathological changes in the liver (44). Wild ginseng cambial meristematic cells protect the liver against GalN-induced inflammation, and sesamin ameliorates D-GaIN/lipopolysaccharide-induced hepatic damage (45,46). Forsythiaside has also been reported as a protective compound against lipopolysaccharide (LPS)/D-GalN-induced liver injury (47).…”

Section: Discussionmentioning

confidence: 99%

An Antioxidant Combination Improves Histopathological Alterations and Biochemical Parameters in D-Galactosamine- Induced Hepatotoxicity in Rats

Çatal¹,

Tunalı²,

Bolkent³

et al. 2017

Eur J Biol

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The protective effects of a combination of antioxidants on histopathological changes and biochemical parameters were examined in D-galactosamine (D-GaIN)-induced hepatotoxicity in rats. Physiological saline solution was injected intraperitoneally into the control group, while D-GaIN (500 mg kg-1) was administered intraperitoneally into the experimental animals. The combination of 100 mg/kg/day ascorbic acid, 100 mg/kg/day alpha tocopherol, 15 mg/kg/day beta carotene, and 0.2 mg/kg/day sodium selenate was administered orally to intact control rats for 3 days. The same antioxidant combination was given to the D-GaIN group. Liver and blood samples were used for histopathological and biochemical assays. Liver tissues were significantly damaged by D-GaIN administration based on the histopathological findings. Serum aspartate and alanine transaminase, gamma glutamyl transpeptidase, alkaline phosphatase, lactate dehydrogenase, sialic acid, and uric acid levels increased. Serum and liver glutathione levels decreased, and serum superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase, catalase activities as well as lipid peroxidation values increased in the D-GaIN group. In contrast, administration of the antioxidants reversed the histopathological and biochemical changes in the liver of animals administered D-GaIN. In conclusion, the administration of a combination of antioxidants suppressed histopathological changes and biochemical parameters in rats given D-GaIN.

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Section: Discussionmentioning

confidence: 99%

An Antioxidant Combination Improves Histopathological Alterations and Biochemical Parameters in D-Galactosamine- Induced Hepatotoxicity in Rats

Çatal¹,

Tunalı²,

Bolkent³

et al. 2017

Eur J Biol

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“…Previous studies have revealed that LPS may activate Kupffer cells, which can mediate the hepatic inflammatory process by producing TNF-α, IL-1β and IL-6, as well as other proinflammatory cytokines (18,19). TNF-α is an important inflammatory mediators involved in LPS/GalN-induced liver injury, which can potentially induce apoptosis of hepatocytes, subsequently leading to organ failure (20)(21)(22). In addition, TNF-α may initiate the inflammatory cascade and induce the production of other cytokines, including IL-1β and IL-6 (23).…”

Section: A B Discussionmentioning

confidence: 99%

Nobiletin attenuates lipopolysaccharide/D-galactosamine-induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated cytokine production

Chen

et al. 2016

Molecular Medicine Reports

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Inflammation and oxidative stress serve an important role in the development of lipopolysaccharide/D-galactosamine (LPS/GalN)‑induced acute liver injury. Nobiletin, which is found in high quantities in the peel of citrus fruits, is able to modulate immune responses, including inflammatory response and oxidative stress. The present study aimed to evaluate the protective effects of nobiletin on LPS/GalN‑induced acute liver injury. Male C57BL/6 mice were intraperitoneally treated with nobiletin (50, 100 and 200 mg/kg) 2 h prior to LPS/GalN injection. Liver injury was observed in the LPS/GalN group, as demonstrated by increased levels of serum hepatic enzymes and hepatic inflammatory mediators, as well as by histopathological alterations. Treatment with nobiletin reduced serum alanine aminotransferase and aspartate aminotransferase levels, improved hepatic structure, and suppressed hepatic interleukin (IL)‑1β, IL‑6 and tumor necrosis factor‑α production 24 h after LPS/GalN exposure. Western blot analysis revealed that nobiletin treatment inhibited inducible nitric oxide synthase and cyclooxygenase‑2 liver expression. In addition, nobiletin suppressed LPS/GalN‑induced phosphorylation and degradation of inhibitor of nuclear factor (NF)‑κB (IκB)α, as well as NF‑κB p65 translocation into the nucleus. Nobiletin also upregulated the expression of nuclear NF‑E2‑related factor 2 (Nrf2) and cytoplasmic heme oxygenase‑1. In conclusion, these results indicate that nobiletin serves a protective role in LPS/GalN‑induced acute liver injury via activation of the Nrf2 antioxidant pathway and subsequent inhibition of NF‑κB‑mediated cytokine production. These findings support the potential for nobiletin as a therapeutic agent for the treatment of acute liver injury.

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“…This results to multiple organ disfunction syndromes and hepatic encephalopathy [66,67]. In lipopolysaccharide/d-galactosamine (LPS/d-GalN)-induced FHF mice model [68], 100 ppm of sesamin shows improved mortality and promotes serum aminotransferases activity for 6 h. Moreover, sesamin possess hepatoprotection by reducing the regulation of expression of hepatic TNF-α mRNA and protein as well as intercellular adhesion molecule-1 (ICAM-1) and endothelial cell adhesion molecule-1 (ECAM-1). Similarly, sesamin downregulates the expression of TLR4 hindering the MAPK and NF-кB signaling pathway.…”

Section: Liver Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

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The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

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Sesamin ameliorates lipopolysaccharide/d-galactosamine-induced fulminant hepatic failure by suppression of Toll-like receptor 4 signaling in mice

Cited by 29 publications

References 32 publications

An Antioxidant Combination Improves Histopathological Alterations and Biochemical Parameters in D-Galactosamine- Induced Hepatotoxicity in Rats

An Antioxidant Combination Improves Histopathological Alterations and Biochemical Parameters in D-Galactosamine- Induced Hepatotoxicity in Rats

Nobiletin attenuates lipopolysaccharide/D-galactosamine-induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated cytokine production

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

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