Sesame: An unrecognized trigger of food protein-induced enterocolitis syndrome

Ovadia, Adi; Nahum, Amit; Tasher, Diana; Abiri, Shirli; Epov, Larisa; Kessel, Aharon; Dalal, Ilan

doi:10.1016/j.jaip.2018.05.007

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…As noted above, sesame has been associated recently with AFPIES and EOE [66][67][68][69]. However, the biochemical nature of allergens responsible for triggering these immune reactions is unknown.…”

Section: The Biochemical Diversity Of Sesame Allergens: Proteins and mentioning

confidence: 99%

“…The fourth type involves acute reactions with colic and diarrhea within 1-4 h upon eating sesame. This condition is known as acute food protein-induced enterocolitis syndrome (AFPIES) with explosive (or projectile) vomiting as the most common symptom [66,67]. This reaction can be potentially fatal in infants and children.…”

Section: Sesame Allergy: a Complex Spectrum Of Clinical Presentationsmentioning

confidence: 99%

“…Sesame is also increasingly linked to two other less understood types of allergic reactions: acute food-protein induced enterocolitis syndrome (AFPIES) and eosinophilic esophagitis (EOE) [66][67][68][69]. Both of these are non-IgE allergic reactions mediated by unknown mechanisms.…”

Section: Does Sesame Use Additional Immune Mechanisms To Trigger Allementioning

confidence: 99%

“…), can trigger this, and so also can sesame. However, authors note that there is lack of awareness on this issue as this is a relatively newly identified immune disorder [67]. Furthermore, another recent study found that compared to subjects with other food allergies, subjects with sesame allergy had 2.5-fold higher rates of AFPIES [2].…”

Section: Does Sesame Use Additional Immune Mechanisms To Trigger Allementioning

confidence: 99%

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The Global Rise and the Complexity of Sesame Allergy: Prime Time to Regulate Sesame in the United States of America?

Gangur

Acharya

2020

Allergies

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Sesame allergy is a life-threatening disease that has been growing globally with poorly understood mechanisms. To protect sensitive consumers, sesame is regulated in many countries. There were four research goals for this work on sesame allergy: (i) to map the timeline, and the extent of its global rise; (ii) to dissect the complexity of the disease, and its mechanisms; (iii) to analyze the global regulation of sesame; and (iv) to map the directions for future research and regulation. We performed a literature search on PubMed and Google Scholar, using combinations of key words and analyzed the output. Regulatory information was obtained from the government agencies. Information relevant to the above goals was used to make interpretations. We found that: (i) the reports appeared first in 1950s, and then rapidly rose globally from 1990s; (ii) sesame contains protein and lipid allergens, a unique feature not found in other allergenic foods; (iii) it is linked to five types of diseases with understudied mechanisms; and (iv) it is a regulated allergen in 32 advanced countries excluding the USA. We also provide directions for filling gaps in the research and identify implications of possible regulation of sesame in the USA.

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Section: The Biochemical Diversity Of Sesame Allergens: Proteins and mentioning

confidence: 99%

Section: Sesame Allergy: a Complex Spectrum Of Clinical Presentationsmentioning

confidence: 99%