Serum γ-glutamyltransferase as Oxidative Stress Marker in Pre-and Postmenopausal Iraqi Women

Abdul‐Rasheed, Omar F.; Al-Shamma, Ghassan A.; Zillo, Bushra H.

doi:10.5001/omj.2010.83

Cited by 13 publications

(14 citation statements)

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“…Increased activity of GGT may be linked to greater oxidative stress. Therefore, the relationship between various diseases and GGT levels has been investigated in several studies [7][8][9][10][11]. A large Austrian study showed for the first time the prognostic value of GGT with regard to fatal events caused by congestive heart failure (CHF) in apparently healthy subjects [12].…”

Section: Introductionmentioning

confidence: 99%

Serum gamma-glutamyl transferase levels and in-hospital mortality in patients with acute heart failure

et al. 2014

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A b s t r a c tBackground: Acute heart failure (AHF) is a major cause of hospitalisation, morbidity and mortality worldwide. Gamma-glutamyl transferase (GGT) is an enzyme responsible for the extracellular catabolism of antioxidant glutathione and a potential risk indicator of cardiac mortality. Limited data exists on the prognostic value of circulating levels of GGT in patients hospitalised due to AHF. Aim:To study the association between baseline GGT activity and in-hospital mortality in AHF patients. Methods:The study cohort consisted of 183 AHF patients with left ventricular ejection fraction (LVEF) < 50%. The primary endpoint was in-hospital mortality. Patients were divided into two groups according to in-hospital mortality. The relationship between GGT activity and in-hospital mortality was tested using logistic regression models, adjusting for clinical characteristics and echocardiographic findings. Results:After adjustment for possible confounders, GGT level was significantly related (OR 1.056, 95% CI 1.018-1.096, p = 0.04) to in-hospital mortality Conclusions: Elevated GGT activity is an independent predictor of short-term mortality in patients with AHF and reduced LVEF.

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Section: Introductionmentioning

confidence: 99%

Serum gamma-glutamyl transferase levels and in-hospital mortality in patients with acute heart failure

et al. 2014

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“…Old age is well known as an important risk factor for many kinds of malignancies. Several authors have reported that the serum γ‐GTP level is influenced by oxidative stress (Abdul‐Rasheed et al., ), and oxidative stress with the release of reactive oxygen species is likely to contribute to the development of both NASH and HCC (Hashimoto and Tokushige, ). Oxidative stress may favor tumorigenesis by promoting inflammation and cell proliferation, or it may directly induce cancer‐promoting gene mutations (Hu et al., ).…”

Section: Discussionmentioning

confidence: 99%

Hepatic and Extrahepatic Malignancies in Cirrhosis Caused by Nonalcoholic Steatohepatitis and Alcoholic Liver Disease

Kodama

Tokushige

Hashimoto

et al. 2013

Alcoholism Clin & Exp Res

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“…These grains release sugar slowly in the blood and also diminish the glucose absorption 57,58 . These grains have also been demonstrated to exhibit beneficial effects on cholesterol levels, which is also due to their high dietary fibre and phytochemical content.…”

Section: Fig 7: Effect Of Selected Minor Millets On Gamma Glutamyl Tmentioning

confidence: 99%

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2017

IJPSR

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Diabetes mellitus, coronary artery disease and oxidative stress are some of the important complications encountered by women during menopause due to decrease in estrogen levels. Food intake has a strong impact on menopausal women and a well balanced diet is important for good health and to combat some of the complications of menopause to certain extent. Minor millets has much health benefits and help to overcome non-communicable diseases like diabetes mellitus, obesity, hyperlipidemia, cardio-vascular diseases, etc. It is rich in micronutrients, especially vitamin B and minerals, Phytochemicals and dietary fiber. The phenolic compounds in minor millets also helps in the prevention of chronic diseases like Cancer. Minor millets like Paspalum scrobiculatum L., Panicum sumatrense Rothex Roem. and Schult, Eichinochola frumentacea Link and setaria italic (L.) P. Beauv. were chosen for the study. The bilaterally ovariectomized rat is an animal model for the studies related to menopause. The powdered minor millets were mixed with rat pellet and fed to the ovariectomised rats. After three months of the study, the blood was collected and analysed for Blood Glucose, Serum Lipid profile, TBARS, Gammaglutamyltransferase. There was a significant (P< 0.05) decrease in the serum glucose,HbA1c, LDL cholesterol, Triglycerides, TBARS and GGT and improvement in serum HDL cholesterol in the Minor millets fed group compared to the control(SHAM operated). Thus Minor millets chosen for the study has the ability to keep blood glucose level and serum lipid level in control and have the ability to reduce the oxidative stress parameters.

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Serum γ-glutamyltransferase as Oxidative Stress Marker in Pre-and Postmenopausal Iraqi Women

Abstract: Serum γ-glutamyltransferase may be considered as an index of oxidative stress associated with menopause.

Cited by 13 publications

References 10 publications

Serum gamma-glutamyl transferase levels and in-hospital mortality in patients with acute heart failure

Serum gamma-glutamyl transferase levels and in-hospital mortality in patients with acute heart failure

Hepatic and Extrahepatic Malignancies in Cirrhosis Caused by Nonalcoholic Steatohepatitis and Alcoholic Liver Disease

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