Hepatic and Extrahepatic Malignancies in Cirrhosis Caused by Nonalcoholic Steatohepatitis and Alcoholic Liver Disease

Abstract

Comparison between NASH-LC and ALD-LC revealed similar HCC development curves. However, the risk factors for HCC and extrahepatic malignancies differed between the 2 diseases. In ALD-LC, the incidences of HCC and extrahepatic cancer are similar. When treating LC patients with NASH or ALD, the risk factors and extrahepatic malignancies associated with ALD-LC should be assessed.

Systematic review with meta‐analysis: risk of hepatocellular carcinoma in non‐alcoholic steatohepatitis without cirrhosis compared to other liver diseases

“…After ensuring no duplicates were present, we screened titles and abstracts, and 51 studies were assessed for eligibility through full‐text review. Through the qualitative systematic review process described in detail in the methods section, 19 observational case‐control or cohort studies met the inclusion criteria for quantitative synthesis in our meta‐analysis. No additional studies were appropriate for inclusion based on our a priori determined inclusion and exclusion criteria.…”

Predictors of malignancies and overall mortality in Japanese patients with biopsy‐proven non‐alcoholic fatty liver disease

“…6,16,17 In Japan, Kodama et al reported that the incidence of extrahepatic malignancies is relatively low (1.4%, 1/72) in patients with NASH cirrhosis compared to those with alcoholic cirrhosis (8.2%, 7/85). 18 In the future, we should compare the incidence of extrahepatic cancers in NAFLD to that in other chronic liver diseases such as alcoholic liver disease (ALD).…”

Is Hepatocellular Cancer the Same Disease in Alcoholic and Nonalcoholic Fatty Liver Diseases?

“…High serum γ-glutamyl transferase (GGT) and a higher Child-Pugh score were reported as risk factors for HCC in NAFLD 9 . Excess iron deposition in hepatocytes and the C282Y HFE mutation frequent in subjects of European descent, were associated with elevated HCC risk in ALD patients, but not in HCV-infected patients 10 .…”